From: pinnerite@gmail.com   
      
   On Tue, 17 Dec 2024 14:48:17 -0500   
   Paul  wrote:   
      
   > On Tue, 12/17/2024 1:02 PM, vallor wrote:   
   > > On Fri, 13 Dec 2024 21:21:04 -0800, Bobbie Sellers wrote:   
   > >   
   > >> Hi denizens,   
   > >>   
   > >> 	I was a constant user of aspirin including St.Joseph's aspirin for   
   > >> children from an early age. I used to think it was harmless a minor   
   > >> pain killer.   
   > >> 	In the 1970s it destroyed my life. I didn't realize it at the   
   > >> time as I had a viral infection according to PCP of the moment. I   
   > >> was sent home with instructions to drink lots of water and to take   
   > >> aspirin. I overdid the aspirin because the fever messed up my head.   
   > >>   	I over did the aspirin but did not realize anything was   
   > >> wrong until a bit later another month or so when my shins broke   
   > >> out in red lumps which is english for Erythema Nodosum. I learned   
   > >> about by visiting San Francisco General and had to go repeatedly   
   > >> before they loosened their tight asses and prescribed a cortisone   
   > >> by mouth for my red lumps and learned that I was sensitive to all   
   > >> the drugs in the same chemical group as aspirin which is all the   
   > >> Salicylate drugs. Salicylates also occur in fruits and vegetables.   
   > >> 	Ok so then I got allergic to wheat, animal dairy products   
   > >> but specifically those with animal casein. Originally this was   
   > >> just cows milk but after a few years I became allergic to goat   
   > >> milk and sheep milk cheese.   
   > >> 	Then when I was 46 I got very ill maybe from exertion   
   > >> but after that whenever I exerted myself I ran the risk of   
   > >> being terribly ill. Worse exercise which had been my friend   
   > >> since young adulthood became poisonous to my body.   
   > >> 	Now this used to be called Chronic Fatigue Syndrome   
   > >> but I prefer Systemic Exertional Intolerance Disease. It happens   
   > >> after an illness which seems to resolve but recurs when   
   > >> exercise is attempted.   
   > >> 	At times I thought it was over and would go out as   
   > >> I was used to doing for the first part of my life and make   
   > >> myself sick all over again. And it causes brain fog which   
   > >> is why I did not figure out that exercise was making me   
   > >> ill.   
   > >>   
   > >> 	Legal over the counter drugs can destroy your life   
   > >> so be careful. There is no cure for this post-viral problem.   
   > >> I had to give up many things like motorcycling and driving.   
   > >> I had to give up the motorbikes because I was getting cramps   
   > >> in my throttle hand and a bit later gave up driving because   
   > >> I could no longer stay awake enough to drive. I have lived   
   > >> in the same studio apartment now for over 50 years and it is   
   > >> crammed full with stuff of great interest to me at one time   
   > >> which is now just somewhat valuable clutter.   
   > >>   
   > >> 	I have told my tale, heed it and tell it to people   
   > >> who think that OTC drugs are safe. Remember that alcohol   
   > >> is legal and can be simply deadly or destroy your health   
   > >> just like tobacco.   
   > >>   
   > >> 	bliss-the hobbler   
   > >   
   > > Hi Bobbie,   
   > >   
   > > My heart goes out to you.  Sorry you've been going through all that.   
   > >   
   > > The story has, though, cast a pall over the newsgroup, at least   
   > > from my perspective.  Human frailty being what it is, I can understand   
   > > the necessity of getting the story out there -- but I wondered if you have   
   > > something to say about Ubuntu? :)   
   > >   
   >   
   > The "fever" might actually have been an aspirin overdose.   
   >   
   >   https://en.wikipedia.org/wiki/Salicylate_poisoning   
   >   
   > And this is Bobbies condition, right here. Right at the   
   > end of that article, it vectors off to this article.   
   >   
   > https://en.wikipedia.org/wiki/Reye_syndrome   
   >   
   >    "The cause of Reye syndrome is unknown.[2] It usually begins shortly after   
   >     recovery from a viral infection, such as influenza or chickenpox.[1]   
   About   
   >     90% of cases in children are associated with aspirin (salicylate) use.[2]   
   >     Inborn errors of metabolism are also a risk factor.[3] The syndrome is   
   >     associated with changes on blood tests such as a high blood ammonia   
   level,   
   >     low blood sugar level, and prolonged prothrombin time.[2] Often, the   
   liver   
   >     is enlarged in those who have the syndrome.[2]   
   >   
   >     Prevention is typically by avoiding the use of aspirin in children.[1]   
   <===   
   >   
   >     When aspirin was withdrawn for use in children in the US and UK in the   
   1980s,   
   >     a decrease of more than 90% in rates of Reye syndrome was observed.   
   >    "   
   >   
   > Acetyl salicylic acid is also an antiviral, and has some sort of RNA   
   activity.   
   > It might have been used for that, if not for the contraindications of   
   Aspirin.   
   > Aspirin kills viruses, but it also seems to have other effects. This means   
   > it has too many non-specific effects perhaps, to be consumed like popcorn.   
   >   
   > https://pmc.ncbi.nlm.nih.gov/articles/PMC5155651/   
   >   
   > *******   
   >   
   > I think Bobbie is focusing on the wrong thing here. Organic chemistry   
   > is of relatively recent origin. Chemists started extracting things from   
   > coal tars and crude oil. The chemists were so stupid at the time, as to   
   > sniff and (ugh) taste the purified materials extracted. Some of the   
   > materials extracted were carcinogens. As a chemist, we give a tip of the   
   > hat to those dead people, because they effectively taught us some   
   > new behaviors in chem lab -- you don't "inhale" from the vat,   
   > neither do you "taste" anything you make. We also learned from that   
   > early chemistry, that "anything with a chlorine or a halogen bonded   
   > to it, regard it as a carcinogen before determining otherwise".   
   >   
   >    "By 1899, Bayer had dubbed this drug Aspirin and was selling it globally."   
   >   
   > Aspirin was likely invented before a lot of our other pharmaceuticals.   
   > The testing process for proving a compound is "safe and effective",   
   > was likely a lot more crude and not very good.  This means we "accepted"   
   > the material, without a thorough workup. Modern drugs go through a lot   
   > more testing steps than the Aspirin described in Wikipedia.   
   >   
   > There are currently around 20 million organic compounds. We've made so   
   > many of them, that some, they have a name and a melting point, and no   
   > other determination of properties has been done. We don't ingest these.   
   > The number of materials commonly in circulation, is a lot less than that.   
   > And orders of magnitude less, are used as therapeutic drugs.   
   >   
   > When the radioactive material "radium" was in vogue, some genius added   
   > it to a cough syrup. Some gentleman consumed a quantity of the material...   
   > and his jaw fell off (lower jaw detached). This put a damper on the   
   > consumption of the medication. Now, that's how we used to do things :-)   
      
   [continued in next message]   
      
   --- SoupGate-DOS v1.05   
    * Origin: you cannot sedate... all the things you hate (1:229/2)