Abstract•   
        
   Biological organisms use complex molecular networks to navigate their   
   environment and regulate their internal state. The development of synthetic   
   systems with similar capabilities could lead to applications such as smart   
   therapeutics or fabrication    
   methods based on self-organization. To achieve this, molecular control   
   circuits need to be engineered to perform integrated sensing, computation and   
   actuation. Here we report a DNA-based technology for implementing the   
   computational core of such    
   controllers. We use the formalism of chemical reaction networks as a   
   'programming language' and our DNA architecture can, in principle, implement   
   any behaviour that can be mathematically expressed as such. Unlike logic   
   circuits, our formulation naturally    
   allows complex signal processing of intrinsically analogue biological and   
   chemical inputs. Controller components can be derived from biologically   
   synthesized (plasmid) DNA, which reduces errors associated with chemically   
   synthesized DNA. We implement    
   several building-block reaction types and then combine them into a network   
   that realizes, at the molecular level, an algorithm used in distributed   
   control systems for achieving consensus between multiple agents.   
      
   http://www.nature.com/nnano/journal/vaop/ncurrent/full/nnano.2013.189.html   
      
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