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   Message 90,301 of 90,757   
   Norm Why to All   
   Angiotensin converting enzyme (ACE2)   
   23 Apr 20 08:03:11   
   
   From: nobody@microsoft.com   
      
   Angiotensin is a peptide hormone involved in control of blood pressure.   
   Angiotensin converting enzyme (ACE2)  is a cell membrane bound protein that   
   converts a prohormone into active angiotensin hormone.   
      
   ACE2 is newsworthy because it is the binding site for SARS-CoV-2 virus, the   
   cause of Covid-19 disease and sky rocketing global pandemic. As many as half   
   a billion lives may be lost; much worse than the Spanish Flu 1918-1919.   
      
   SARS-CoV-2 virus is mutating and evolving quickly. Human evolution unfolds   
   at a much slower rate. Human evolution involves population changes in allele   
   frequencies. Alleles are different versions of genes.. Some people have   
   brown hair, some red, blond or whatever. There are 32 known alleles of the   
   ACE2 gene located on the X-chromosome. Women have two X, men one X. This has   
   significance to the differing susceptibility to Covid-19 disease by men or   
   women and between ethnic/racial groups. Epidemiology is interested in such   
   questions.   
      
   Men have 32 possible alleles of the ACE2 gene. Some are at more at risk of   
   death from Covid-19 disease, some less. Mathematically, within the human   
   gene pool women may have 32 x 32 = 1024 combinations of ACE2 alleles.   
   Virus - cell interactions have been ongoing for 4 billion years, one of the   
   driving forces of natural selection.   
      
   X-chromosome is also the repository for brain related genes. The   
   X-chromosome has been under selective pressure during the evolution of   
   increased intelligence in humans and our ancestors.   
      
   One might speculate, "Do pandemics like Covid-19 disease increase   
   intelligence in the human gene pool over time?"   
      
   --- SoupGate-Win32 v1.05   
    * Origin: you cannot sedate... all the things you hate (1:229/2)   

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