XPost: alt.drugs.psychedelics, alt.drugs, alt.drugs.rfg   
   XPost: rec.drugs.psychedelic   
   From: rfgdxm@KILLSPAMMERSmochamail.com   
      
   Matthew Isleb wrote:   
   > On Thu, 11 Dec 2003 06:27:43 +0000, Boris Gjenero wrote:   
      
   >> I suppose this might be why dissociatives and serotonergics share   
   >> certain effects.   Heck, it's even evidence for the great "is DXM   
   >> psychedelic" debate!   
   >   
   > The article could just as easily be "evidence" that speed is a   
   > psychedelic, which really dilutes its "is DXM psychedelic" effect.   
   >   
   > Now that I think about it, this article is a perfect example of how   
   > clinicians use an extremely loose term "psychotomimetic" that isn't   
   > necessarily the same as the term we know as "psychedelic." Once again,   
   > Robert has taken a scientific article and applied his own bias. Don't   
   > let him fool you. The article never used the word "psychedelic" even   
   > once.   
      
      Again, you demonstrate you don't know what you are talking about.   
   Look at the citations below. Shulgin repeatedly uses the term   
   psychotomimetic for his compounds. In the last he mentions that 2   
   mescaline analogues are 6 to 12 more potent psychotomimetics than   
   mescaline. Psychedelic and psychotomimetic are synonyms as used by   
   scientists.   
      
      
   Experientia. 1963 Mar 15;19:127-8.   
      
   Psychotomimetic agents related to mescaline.   
      
   SHULGIN AT.   
      
   PMID: 13988773 [PubMed - OLDMEDLINE for Pre1966]   
   ---   
   Nature. 1964 Mar 14;201:1120-1.   
      
   3-METHOXY-4,5-METHYLENEDIOXY AMPHETAMINE, A NEW PSYCHOTOMIMETIC AGENT.   
      
   SHULGIN AT.   
      
   PMID: 14152788 [PubMed - OLDMEDLINE for Pre1966]   
   ---   
   Psychopharmacol Commun. 1975;1(1):93-8.   
      
   Centrally active phenethylamines.   
      
   Shulgin AT, Carter MF.   
      
   The two-carbon homologs of two potent psychotomimetic agents are   
   described.   
   Unlike the parent isopropylamine compounds   
   (4-methyl-2,5-dimethoxyamphetamine, DOM, STP; and   
   4-bromo-2,5-dimethoxyamphetamine, PBR, 4-BR) these phenethylamines lead   
   to   
   an intoxication state which is, in normal subjects, of short duration   
   and of   
   greatly increased sensory enhancement, but which does not superimpose   
   hallucinogenesis. These two phenethylamines,   
   4-methyl-2,5-dimethoxyphenethylamine (II) and   
   4-bromo-2,5-dimethoxyphenethylamine (III), are active in man at oral   
   levels   
   of 0.1 to 0.2 mg/Kg, approximately one tenth the potency of their   
   three-carbon counterparts.   
      
   PMID: 1223994 [PubMed - indexed for MEDLINE]   
   ---   
   J Med Chem. 1975 Dec;18(12):1201-4.   
      
   Psychotomimetic phenylisopropylamines. 5.   
   4-Alkyl-2,5-dimethoxyphenylisopropylamines.   
      
   Shulgin AT, Dyer DC.   
      
   A homologous series of 4-alkyl-2,5-dimethoxyphenylisopropylamines (alkyl   
   = H   
   through n-C5H11 and t-C4H9) was synthesized and compared with mescaline   
   as   
   serotonin agonists in a sheep umbilical preparation. The three-carbon   
   homolog 6d was found to be the most potent of the straight-chain series   
   in   
   accordance with its observed psychotomimetic effectiveness in man.   
      
   PMID: 1195275 [PubMed - indexed for MEDLINE]   
   ---   
   J Pharm Sci. 1976 OCT;65(10):1554-6.   
      
   Sulfur analogs of psychotomimetic amines.   
      
   Nichols DE, Shulgin AT.   
      
   The syntheses and physical properties are described for   
   2,5-dimethoxy-4-methylthiophenylethylamine and   
   2,5-dimethoxy-4-methylthiophenylisopropylamine. The latter compound is   
   the   
   sulfur analog of the psychotomimetic phenylisopropylamines   
   2,4,5-trimethoxyphenylisopropylamine and   
   2,5-dimethoxy-4-methylphenylisopropylamine wherein the methylthio group   
   replaces a methoxy group or a methyl group, respectively. This compound   
   is   
   predicted to be about 30 times as active as mescaline.   
   ---   
   J Pharm Sci. 1979 Jul;68(7):906-7.   
      
   Molecular connectivity analysis of hallucinogenic mescaline analogs.   
      
   Glennon RA, Kier LB, Shulgin AT.   
      
   The hallucinogenic (psychotomimetic) potency of 10 mescaline analogs was   
   examined by molecular connectivity analysis. Potencies could be   
   described by   
   a two-term relating equation, which explained 94% of the variance in   
   activity, on the basis of structural variation, 2,5-Dimethoxy   
   substitution   
   as well as the nature of the 4-position substituent played an important   
   role   
   in determining hallucinogenic potency. With the relating equation,   
   reasonable potency predictions were made for six compounds not included   
   in   
   the initial investigation.   
      
   PMID: 458614 [PubMed - indexed for MEDLINE]   
   ---   
   Arzneimittelforschung. 1980;30(5):825-30.   
      
   [Research on the central activity and analgesia of N-substituted analogs   
   of   
   the amphetamine derivative 3,4-methylenedioxyphenylisopropylamine]   
      
   [Article in German]   
      
   Braun U, Shulgin AT, Braun G.   
      
   N-substituted analogs of 3,4-methylenedioxyphenylisopropylamine (MDA)   
   were   
   tested ror analgesic potency and influence on motor activity in mice   
   following potency and influence on motor activity in mice following oral   
   administration. These compounds also were tested for thei   
   psychotomimetic   
   potency in man. Unsubstituted MDA and its monoalkyl-homologs with a low   
   number of C-atoms (N-methyl-, N-methyl-, N-ethyl-MDA) showed both   
   enhancement of motor-activity in mice and psychotomimetic effects in   
   man.   
   MDA and N-methyl-MDA also showed an analgesic effec wthich was enhanced   
   by   
   the inclusion of a weakly labis group (N-mallyl, N-hydroxyethyl). These   
   latter two compounds, however, did not influence motor-activity, which   
   makes   
   them more recommendable as possible analgesic compounds. Structural   
   parallels between these compounds, morphine, endorphins and enkephalins,   
   may   
   explain their similar spectrum of pharmacological effects.   
      
   PMID: 7190428 [PubMed - indexed for MEDLINE]   
   ---   
   J Med Chem. 1981 Nov;24(11):1348-53.   
      
   Sulfur analogues of psychotomimetic agents. Monothio analogues of   
   mescaline   
   and isomescaline.   
      
   Jacob P 3rd, Shulgin AT.   
      
   Two monothio analogues of mescaline and three monothio analogues of   
   2,3,4-trimethoxyphenethylamine (isomescaline) have been synthesized and   
   characterized. Only the two mescaline analogues (3-and 4-thiomescaline)   
   were   
   found to be psychotomimetics in man, being 6 and 12 times more potent   
   than   
   mescaline, respectively. All five compounds can serve as substrates for   
   bovine plasma monoamine oxidase in vitro, but no positive correlation is   
   apparent between the extent of enzymatic degradation and human   
   psychotomimetic potency.   
      
   PMID: 7310812 [PubMed - indexed for MEDLINE]   
      
   --- SoupGate-Win32 v1.05   
    * Origin: you cannot sedate... all the things you hate (1:229/2)