XPost: alt.drugs.psychedelics, alt.drugs, alt.drugs.rfg   
   XPost: rec.drugs.psychedelic   
   From: be@here.now   
      
   Right. Serotonin is produced in these raphe nuclei in the brain stem,   
   the axons of which extend throughout the CNS, including to the 5ht2a   
   receptor sites mostly concentrated in the cereberal cortex. LSD's   
   primary action is post-synaptic action at these 5ht2a receptors, not   
   pre-synaptic action in the RN. In fact, some theorize that the   
   pre-synaptic action in the RN is the result of a feedback mechanism   
   that reacts to effects of the action at the 5ht2a sites.   
      
   Once upon a timeless moment,   
   BilZ0r  hallucinated:   
   > The Raphe nuclei is the major source of serotonin in the cortex, just as   
   > the Locus Ceruleus is the major source of noradrenergic inervation and   
   > the A8-A15 nuclei are the major source of dopamine.   
   >   
   > I'm not going to able to fine a journal article reference, but if you own   
   > a copy of Principles of Neural Science, Kandel et al., then look on page   
   > 893. where the opening line is "Most sertonergic neurons are located   
   > along the midline of the brain stem in the raphe nuclei". And he's really   
   > understating it there because the only other ones I can think of are the   
   > ones up near the pineal gland (melatonergic, but metabolism isn't   
   > perfect), and peripheral neurons.   
   >   
   > glog  wrote in news:slrnbtmqtm.aca.be@be.here.now:   
   >   
   >> Once upon a timeless moment,   
   >> BilZ0r  hallucinated:   
   >>> Just because it dosn't mean it is inconsequencial to its   
   >>> hallucinogenic action dosn't make it anyless real. i.e.   
   >>> Antihistamines... many of them are taken by people going senile   
   >>> because they have a strong anticholinergic action (which helps in 10%   
   >>> of senility cases). The anticholinergic action is inconsequencial to   
   >>> its antihistaminergic action, but most antihistamines are still   
   >>> anticholinergic.   
   >>>   
   >>> Just because a drug binds to a whatever receptor, dosn't make that   
   >>> drug whatever-ergic. LSD decreases the amount of serotonin in the   
   >>> cortex, it is hence, and anti-serotonergic. It increase the amount of   
   >>> glutamate, you -could- call it a glutaminergic then.   
   >>>   
   >>   
   >> I agree its loose terminology to call LSD "serotonergic".  But you   
   >> haven't cited any evidence that LSD decreases the amount of serotonin   
   >> in the cortex, only that it inhibits activity in raphe neurons. Where   
   >> is your evidence to support your claim below that raphe neurons are   
   >> "the only source of serotonin in the brain"?? It seems just as   
   >> misleading to me to call LSD "anti-serotonergic".   
   >>   
   >>   
   >>   
   >>> glog  wrote in news:slrnbtjrfo.7jv.be@be.here.now:   
   >>>   
   >>>> Once upon a timeless moment,   
   >>>> BilZ0r  hallucinated:   
   >>>>> glog  wrote in news:slrnbtic5s.6jb.be@be.here.now:   
   >>>>   
   >>>>>>> I mean, LSD (and   
   >>>>>>> other indole hallucinogens) are really anti serotonergic.   
   >>>>>>>   
   >>>>>>   
   >>>>>> Huh??   
   >>>>>>   
   >>>>>>   
   >>>>>   
   >>>>> They inhibit the spontaneous activity of the Raphe Nuclei.   
   >>>>   
   >>>> The article you recently posted said "LSD's action at the 5-HT1A   
   >>>> receptor and raphe neurons is inconsequential to its hallucinogenic   
   >>>> action".   
   >>>>   
   >>>>> The only real   
   >>>>> source or serotonin in brain.   
   >>>>   
   >>>> The article you recently posted said "The 5-HT2A receptor, which now   
   >>>> seems to be the only shared and clinically important target of   
   >>>> hallucinogens, has been found throughout the cortex, and   
   >>>> particularly in cortical pyramidal cells.   
   >>>>   
   >>>>   
   >>>>   
   >>>   
   >>   
   >   
      
   --- SoupGate-Win32 v1.05   
    * Origin: you cannot sedate... all the things you hate (1:229/2)