XPost: alt.drugs.psychedelics, alt.drugs, alt.drugs.rfg   
   XPost: rec.drugs.psychedelic   
   From: BilZ0r@TAKETHISOUThotmail.com   
      
   LSDs primary site of action is presynaptically at 5-HT2A on glutaminergic   
   cells which sypanse with frontal cortical pyramidal cells, to potentiate   
   assynchronouc synaptic transmission. Not at pre or post synaptic 5-HT1A   
   receptors.   
      
      
   glog  wrote in news:slrnbtne6o.alr.be@be.here.now:   
      
   > Right. Serotonin is produced in these raphe nuclei in the brain stem,   
   > the axons of which extend throughout the CNS, including to the 5ht2a   
   > receptor sites mostly concentrated in the cereberal cortex. LSD's   
   > primary action is post-synaptic action at these 5ht2a receptors, not   
   > pre-synaptic action in the RN. In fact, some theorize that the   
   > pre-synaptic action in the RN is the result of a feedback mechanism   
   > that reacts to effects of the action at the 5ht2a sites.   
      
   --- SoupGate-Win32 v1.05   
    * Origin: you cannot sedate... all the things you hate (1:229/2)