From: drarwingnuttephd@gmail.com   
      
   Original Investigation | October 20, 2014   
      
   Quantifying the Eating Abnormalities in Frontotemporal Dementia    
      
      
   Rebekah M. Ahmed, MBBS1,2,3; Muireann Irish, PhD1,3,4; Jonathan Kam, MD1,5;   
   Jolanda van Keizerswaard, BSc1; Lauren Bartley, BSc1; Katherine Samaras,   
   PhD6,7; John R. Hodges, MD1,3,5; Olivier Piguet, PhD1,3,5   
   [+] Author Affiliations   
   JAMA Neurol. Published online October 20, 2014. doi:10.1001/jama   
   eurol.2014.1931 Text Size: A A A   
   Article   
   Figures   
   Tables   
   Supplemental Content   
   References   
   Comments   
   ABSTRACT   
   ABSTRACT | INTRODUCTION | METHODS | RESULTS | DISCUSSION | CONCLUSIONS |   
   ARTICLE INFORMATION | REFERENCES   
   Importance  Presence of eating abnormalities is one of the core criteria for   
   the diagnosis of behavioral variant frontotemporal dementia (bvFTD), yet their   
   occurrence in other subtypes of frontotemporal dementia (FTD) and effect on   
   metabolic health is    
   not known.   
      
   Objective  To define and quantify patterns of eating behavior and energy,   
   sugar, carbohydrate, protein, and fat intake, as well as indices of metabolic   
   health in patients with bvFTD and semantic dementia (SD) compared with   
   patients with Alzheimer disease    
   (AD) and healthy control participants.   
      
   Design, Setting, and Participants  Prospective case-controlled study involving   
   patient and caregiver completion of surveys. Seventy-five participants with   
   dementia (21 with bvFTD, 26 with SD, and 28 with AD) and 18 age- and   
   education-matched healthy    
   controls were recruited from FRONTIER, the FTD research clinic at Neuroscience   
   Research Australia in Sydney.   
      
   Main Outcomes and Measures  Caregivers of patients with FTD and AD completed   
   validated questionnaires on appetite, eating behaviors, energy consumption,   
   and dietary macronutrient composition. All participants completed surveys on   
   hunger and satiety. Body    
   mass index and weight measurements were prospectively collected.   
      
   Results  The bvFTD group had significant abnormalities in the domains of   
   appetite (U = 111.0, z = 2.7, P = .007), eating habits   
   (U = 69.5, z = 3.8, P = .001), food preferences (U = 57.0,   
   z = 4.1, P = .001), swallowing (   
   U = 109.0, z = 3.0, P = .003), and other oral behaviors   
   (U = 141.0, z = 2.6, P = .009) compared with the AD group. The   
   bvFTD and SD groups tended to have increased energy consumption. Compared with   
   controls, the bvFTD group had    
   significantly increased carbohydrate intake (251 vs 170 g/d; P = .05) and   
   the SD group had significantly increased sugar intake (114 vs 76 g/d;   
   P = .049). No significant differences in total fat or protein intake   
   between the groups were found.    
   Despite similar energy intake, the SD group had lower hunger and satiety   
   scores compared with the bvFTD group. In contrast, hunger and satiety scores   
   did not differ between the bvFTD group and controls. The abnormal eating   
   behavior was found in the 2    
   groups (bvFTD and SD) with the highest body mass index (F = 4.2,   
   P = .008) and waist circumference (F = 6.4, P = .001).   
      
   Conclusions and Relevance  Abnormal eating behaviors are prominent in patients   
   with bvFTD and those with SD and are not limited to increased appetite. The   
   observed higher intake of sugar and carbohydrates was found in patients with   
   the FTD subtypes and    
   those with higher body mass index and waist circumference and was not   
   explained simply by increased hunger or lower satiety.   
      
      
   http://archneur.jamanetwork.com/article.aspx?articleid=1917548   
      
   --- SoupGate-Win32 v1.05   
    * Origin: you cannot sedate... all the things you hate (1:229/2)