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   sci.med.psychobiology      Dialog and news in psychiatry and psycho      4,736 messages   

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   What You Should Know About Early-Onset A   
   23 Jan 15 12:46:46   
   
   From: hounddog23x@gmail.com   
      
   What You Should Know About Early-Onset Alzheimer’s   
      
   Health   
   January 23, 2015   
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   Julianne Moore won a Golden Globe and is nominated for an Academy Award for   
   her portrayal of an early-onset Alzheimer’s patient in the film Still Alice.   
   Moore’s character, Alice Howland, is just 50 when she is diagnosed, and the   
   movie follows her and    
   her family’s struggle to cope as her memory and mental state decline.   
      
   But what is early-onset Alzheimer’s disease, and who is at risk? Here’s   
   what you should know about the condition that affects about 200,000 people in   
   the United States.   
      
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   Not just for old people   
   Alzheimer’s disease is usually thought of as something senior citizens get.   
   While that is often true, it’s not always the case: Up to 5% of people   
   diagnosed with Alzheimer’s are under age 65—usually in their 40s or   
   50s—and are considered to    
   have an “early onset” or “younger onset” of the disease.   
      
   What You Should Know About Early-Onset Alzheimer’s   
      
   Actress Julianne Moore. (Photo: Getty Images)   
      
   Related: 25 Signs and Symptoms of Alzheimer’s Disease   
      
   Symptoms of early-onset Alzheimer’s are no different than symptoms of more   
   traditional cases, says Mary Sano, PhD, professor of psychiatry and director   
   of Alzheimer’s disease research at Mount Sinai School of Medicine in the   
   Bronx, whom Moore    
   consulted during her research for Still Alice. But because the condition is so   
   rare in adults under 65, the signs may not be recognized as quickly by   
   patients themselves, or by those around them.   
      
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   “By the time people ask for help, something strange has probably been going   
   on for at least six months,” says Sano. “And often, it’s family members   
   and close friends who can provide a point of view that a change has occurred,   
   which can allow that    
   person to realize something is wrong.”   
      
   Because early-onset Alzheimer’s disease is so uncommon, diagnosis may also   
   require testing above and beyond what a senior citizen might undergo. “We   
   want to demonstrate that what’s really present is a cognitive problem and   
   not a psychological or    
   physical problem,” says Sano. “For a younger person, we’ll do a more   
   rigorous workup, including imaging and other tests, because we want to make   
   sure we get this right.”   
      
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   Early-onset disease has a strong genetic component, so family history—if the   
   patient knows enough about it—can be a big part of a person’s diagnosis,   
   as well. A blood test can determine whether someone has a gene mutation that   
   puts them at higher    
   risk for familial Alzheimer’s, but cannot prove whether they have (or will   
   get) the disease.   
      
   Related: 7 Ways to Protect Your Memory   
      
   What it’s like—and what it’s not   
   First things first: Early-onset Alzheimer’s disease is uncommon, and it’s   
   not responsible for most cases of middle-aged forgetfulness—like not being   
   able to remember where you put your keys, or the name of someone you met at a   
   cocktail party last    
   night, for example.   
      
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   Episodes like these, says Sano, are most likely due to preoccupation or   
   periods of temporary stress, and usually aren’t anything to worry about.   
      
   When you should be concerned, she says, is when problems with your memory   
   begin to interfere with your ability to do the things that are most important   
   to you, or when you start to have difficulty completing common, everyday   
   tasks. “It’s the    
   persistence and the erratic nature of the symptoms that’s the real warning   
   sign.”   
      
   In fact, Sano says, people with early-stage Alzheimer’s disease often   
   subconsciously modify or adapt their routines to the point where they don’t   
   even notice specific red-flag incidents. According to the Alzheimer’s   
   Association, warning signs may    
   include the regular use of memory devices, relying on friends and family to do   
   things you used to handle yourself, or withdrawal from work or social   
   activities.   
      
   Related: 12 Unexpected Things That Mess With Your Memory    
      
   Symptoms are different for everyone, but one thing to watch for is difficulty   
   remembering and retaining new information, says Sano. “Not being able to   
   learn your new computer password, or to learn a new activity or take on a new   
   project—those are    
   usually the challenges at the earliest stages of the disease,” she says.   
   As the disease progresses, however, all forms of memory are affected. In Still   
   Alice, Moore’s character becomes concerned when she—a linguistics who is   
   known for her mastery of speech—loses her train of thought during a   
   presentation and cannot    
   think of the words to continue. In other scenes throughout the movie, she gets   
   disoriented while out for a jog, forgets her daughter’s name, and, yes,   
   misplaces her keys.   
      
   As the movie shows, early-onset Alzheimer’s can be especially devastating   
   because people in their 40s and 50s are often still working and caring for   
   children. “They’re at risk for having more functional loss, and having   
   their life and their family   
   s lives affected much more than someone who’s several decades older,”   
   says Sano. “And so the management of the disease really requires a lot of   
   thoughtfulness and a lot of extra service.”   
      
   Related: 15 Diseases Doctors Often Get Wrong   
      
   Treatment and hope   
   There is no cure for Alzheimer’s disease, no matter what age onset occurs.   
   But there are drugs that can slow its progression, and there are ways in which   
   Alzheimer’s patients and their families can better manage living with the   
   disease.   
      
   Staying physically, socially, and mental active can also provide protection   
   against the disease and may help people with early-stage Alzheimer’s disease   
   maintain their cognition longer, says Sano. Specifically, research has shown   
   that doing crossword    
   puzzles and speaking a second language may help slow declines in thinking and   
   memory.   
      
   In addition, there are many opportunities for Alzheimer’s patients to take   
   part in ongoing research, says Sano, which may lead the way to better   
   treatment options. She recommends talking to your doctor or visiting the   
   National Institutes of Health’s    
   Alzheimer’s Disease Education and Referral Center online for information   
   about clinical trials happening near you.   
      
      
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