From: hound23x@gmail.com   
      
   Trends in Immunology    
   November 2014, Vol.35(11):526-537, doi:10.1016/j.it.2014.07.003    
      
   Review    
      
   Influence of the microbiota on vaccine effectiveness    
      
   Yanet ValdezEric M. BrownB. Brett Finlay    
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   Highlights    
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   Gut microbial composition affects immune system function.    
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   The immune system influences host microbial populations.    
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   Microbiota diversity and composition may impact upon vaccine efficacy.    
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   A mechanistic understanding should inform future vaccination strategies.    
   Studies of the relationship between the microbiome and the development and   
   function of the immune system are demonstrating novel concepts that could   
   significantly alter the way we treat disease and promote wellness. Several   
   diseases, including    
   inflammatory bowel disease, allergy/asthma, and diabetes, are associated with   
   changes in composition of the microbiome. Recent findings suggest novel   
   complex mechanisms by which the microbiome impacts immune cell development and   
   differentiation. A major    
   implication of these findings is that the composition of microbiome may   
   ultimately affect vaccine efficacy. We explore here the potential role of the   
   microbiome in vaccine responses in the context of our growing understanding of   
   the relationship between    
   the gastrointestinal microbiota, resident immune cell populations, and   
   systemic immunity.    
      
      
      
   http://www.sciencedirect.com/science/article/pii/S1471490614001148    
      
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