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   Leaks in Brain May Contribute to Dementia   
      
   WebMD News from HealthDay    
   Findings could lead to new treatments, researcher   
   By Robert Preidt   
      
   HealthDay Reporter   
      
   WEDNESDAY, Jan. 21, 2015 (HealthDay News) -- Age-related blood vessel leaks in   
   the brain may contribute to the development of Alzheimer's disease and other   
   types of dementia, according to a new study.   
      
   The findings suggest it may be possible to use brain scans to detect such   
   leaks and repair them in order to prevent damage that can lead to dementia,   
   the University of Southern California researchers said.   
      
   The investigators analyzed contrast-enhanced brain images from 64 people of   
   various ages and found that the brain's protective blood barrier becomes leaky   
   with age. This leakage begins in the hippocampus, an important learning and   
   memory center damaged    
   by Alzheimer's disease.   
      
      
   Depression, Anxiety Can Precede Memory Loss in Alzheimer's, Study Finds   
   "This is a significant step in understanding how the vascular system affects   
   the health of our brains," said lead investigator Dr. Berislav Zlokovic,   
   director of the Zilkha Neurogenetic Institute at the university's Keck School   
   of Medicine.   
      
   "To prevent dementias including Alzheimer's, we may need to come up with ways   
   to reseal the blood-brain barrier and prevent the brain from being flooded   
   with toxic chemicals in the blood," Zlokovic added in a university news   
   release.   
      
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   The study was published Jan. 21 in the journal Neuron.   
      
   Post-death examinations of Alzheimer's patients' brains reveal damage to the   
   blood-brain barrier. However, why and when this damage occurs is unclear, the   
   researchers noted.   
      
   About 5.2 million Americans have Alzheimer's disease, the most common type of   
   dementia. By 2050, about 16 million Americans over age 65 will have dementia,   
   according to the Alzheimer's Association.   
      
      
   SOURCE: University of Southern California, news release, Jan. 21, 2015   
      
      
      
   http://www.m.webmd.com/a-to-z-guides/news/20150121/leaks-in-brai   
   -may-contribute-to-dementia   
      
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