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   Depression, diabetes associated with increased dementia risk   
   Date:   
   April 15, 2015   
   Source:   
   The JAMA Network Journals   
   Summary:   
   Depression and type 2 diabetes mellitus were each associated with an increased   
   risk for dementia and that risk was even greater among individuals diagnosed   
   with both depression and diabetes compared with people who had neither   
   condition, according to a    
   new article    
      
   Depression and type 2 diabetes mellitus were each associated with an increased   
   risk for dementia and that risk was even greater among individuals diagnosed   
   with both depression and diabetes compared with people who had neither   
   condition, according to an    
   article published online by JAMA Psychiatry.   
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   Diabetes and major depression are common in Western populations and as many as   
   20 percent of people with type 2 diabetes mellitus also have depression.   
   Dimitry Davydow, M.D., M.P.H., of the University of Washington School of   
   Medicine, Seattle, and coauthors examined the risk for dementia among   
   individuals with depression, type 2 diabetes or both compared with individuals   
   with neither condition in a    
   group of more than 2.4 million Danish citizens, who were 50 and older and free   
   from dementia from 2007 through 2013.   
   Overall, 19.4 percent of individuals in the group had a diagnosis of   
   depression (477,133 individuals), 9.1 percent had type 2 diabetes (223,174   
   individuals), and 3.9 percent (95,691 individuals) had diagnoses of both   
   diabetes and depression. The average    
   age at initial diagnosis of type 2 diabetes was 63.1 years old and the average   
   age at initial diagnosis of depression was 58.5 years old.   
   The authors found that during the study period, 2.4 percent of individuals   
   (59,663 people) developed dementia and the average age at diagnosis was nearly   
   81 years. Of those individuals who developed dementia, 15,729 people (26.4   
   percent) had depression    
   alone and 6,466 (10.8 percent) had type 2 diabetes alone, while 4,022 (6.7   
   percent) had both conditions.   
   The results of the study indicate that type 2 diabetes alone was associated   
   with a 20 percent greater risk for dementia and depression alone was   
   associated with an 83 percent greater risk, while having both depression and   
   type 2 diabetes was associated    
   with a 117 percent greater risk. The risk for dementia appeared to be even   
   greater among those study participants younger than 65.   
   "In light of the increasing societal burden of chronic diseases, further   
   research is needed to elucidate the pathophysiologic mechanisms linking   
   depression, DM [type 2 diabetes mellitus] and adverse outcomes such as   
   dementia and to develop interventions    
   aimed at preventing these dreaded complications," the study concludes.   
   Commentary: Promoting Healthy Brain Aging   
   In a related commentary, Charles F. Reynolds III, M.D., of the University of   
   Pittsburgh Medical Center, writes: "In conclusion, the study by Katon and   
   colleagues illustrates the need for convergent scientific approaches to meet   
   the challenge of promoting    
   healthy brain aging and cognitive fitness into the last years of life. The   
   convergence of expertise from epidemiology, behavioral and basic science in   
   the biology of aging and brain health are all necessary 'to move the needle'   
   in the demographic    
   challenge that confronts the entire globe."   
   Story Source:   
   The above story is based on materials provided by The JAMA Network Journals.   
   Note: Materials may be edited for content and length.   
   Journal References:   
   Wayne Katon, Henrik Sondergaard Pedersen, Anette Riisgaard Ribe, Morten   
   Fenger-Grøn, Dimitry Davydow, Frans Boch Waldorff, Mogens Vestergaard. Effect   
   of Depression and Diabetes Mellitus on the Risk for Dementia. JAMA Psychiatry,   
   2015; DOI: 10.1001/   
   jamapsychiatry.2015.0082   
   Charles F. Reynolds. Promoting Healthy Brain Aging. JAMA Psychiatry, 2015;   
   DOI: 10.1001/jamapsychiatry.2015.0174   
   Cite This Page:   
   MLA APA Chicago   
   The JAMA Network Journals. "Depression, diabetes associated with increased   
   dementia risk." ScienceDaily. ScienceDaily, 15 April 2015   
      
      
      
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    * Origin: you cannot sedate... all the things you hate (1:229/2)