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   Gut bacteria may trigger auto-immune disease later in life   
      
   IANS | Jan 20, 2015, 10.20AM IST   
      
      
   Researchers have revealed that the colonisation of the gut of young mice by   
   certain types of bacteria can lead to immune responses later in life that are   
   linked to disease.   
      
   This type of damage is a hallmark of auto-immune diseases like systemic lupus   
   erythematosus and systemic sclerosis where organs throughout the body are   
   damaged by wayward immune responses.   
      
   "Our results demonstrate how gut health in young animals may be linked to   
   auto-immune disease in older animals," said Dirk Elewaut, professor at Ghent   
   University Hospital in Belgium, one of the lead authors of the study.   
      
   The microbiome of the young mouse impacts a loss of tolerance of the secondary   
   immune system against proteins in the nucleus of the cell.   
      
   The attack of certain proteins by the body's own immune system can   
   subsequently lead to tissue damage and disease.   
      
   "We have demonstrated a link between the microbiome of young mice and the   
   later onset of auto-immune disease," Elewaut noted.   
      
   Further work is needed to establish the precise molecular mechanisms that lead   
   to the onset of auto-immune diseases in humans but we now have a new path of   
   inquiry that we can pursue and look for potential interventions, the authors   
   concluded.   
      
   The findings were published in The EMBO Journal.   
      
      
   http://m.timesofindia.com/life-style/health-fitness/health/Gut-b   
   cteria-may-trigger-auto-immune-disease-later-in-life/articleshow/45949480.cms   
      
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