From: hounddog23x@gmail.com   
      
   Alzheimer's and Sleep Quality Linked In New Study   
      
   June 5, 2015   
      
      
   How Alzheimer's could be linked to sleep quality.   
      
      
      
   Poor sleep is a channel through which Alzheimer's disease can be triggered, a   
   new study finds.   
      
   Professor Matthew Walker, one of the neuroscientist who authored the study,   
   said:   
      
   "This discovery offers hope.   
      
   Sleep could be a novel therapeutic target for fighting back against memory   
   impairment in older adults and even those with dementia."   
      
   The study is one of the first to look at human rather than animal subjects in   
   this way.   
      
   Professor William Jagust, a leading expert on Alzheimer's disease who co-led   
   the study, said:   
      
   "Over the past few years, the links between sleep, beta-amyloid, memory, and   
   Alzheimer's disease have been growing stronger.   
      
   Our study shows that this beta-amyloid deposition may lead to a vicious cycle   
   in which sleep is further disturbed and memory impaired."   
      
   For the research, 26 older people without dementia were given memory tests and   
   had their brains scanned before and after sleep.   
      
      
      
   Professor Walker explained:   
      
   "The more you remember following a good night of sleep, the less you depend on   
   the hippocampus and the more you use the cortex.   
      
   It's the equivalent of retrieving files from the safe storage site of your   
   computer's hard drive, rather than the temporary storage of a USB stick.   
      
   The more beta-amyloid you have in certain parts of your brain, the less deep   
   sleep you get and, consequently, the worse your memory.   
      
   Additionally, the less deep sleep you have, the less effective you are at   
   clearing out this bad protein.   
      
   It's a vicious cycle.   
      
   But we don't yet know which of these two factors -- the bad sleep or the bad   
   protein -- initially begins this cycle. Which one is the finger that flicks   
   the first domino, triggering the cascade?"   
      
   Dr Bryce Mander, study's lead author, said:   
      
   "The data we've collected are very suggestive that there's a causal link.   
      
   If we intervene to improve sleep, perhaps we can break that causal chain."   
      
   This ties in with evidence of how sleep fights toxins in the brain.   
      
   Professor Walker said:   
      
   "Sleep is helping wash away toxic proteins at night, preventing them from   
   building up and from potentially destroying brain cells,.   
      
   It's providing a power cleanse for the brain.   
      
   The study was published in the journal Nature Neuroscience (Walker et al.,   
   2015).   
      
   Alzheimer's photo from Shutterstock   
      
      
      
   http://www.spring.org.uk/2015/06/alzheimers-and-sleep-quality-li   
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