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   Joe Paxton    
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   Manchester,8 March 2016    
      
   Landmark editorial identifies microbes as major cause of Alzheimer’s Disease    
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   A worldwide team of senior scientists and clinicians have come together to   
   produce an editorial which indicates that certain microbes - a specific virus   
   and two specific types of bacteria - are major causes of Alzheimer’s   
   Disease. Their paper, which    
   has been published online in the highly regarded peer-reviewed journal,   
   Journal of Alzheimer's Disease, stresses the urgent need for further research   
   - and more importantly, for clinical trials of anti-microbial and related   
   agents to treat the disease.    
      
   This major call for action is based on substantial published evidence into   
   Alzheimer's. The team’s landmark editorial summarises the abundant data   
   implicating these microbes, but until now this work has been largely ignored   
   or dismissed as    
   controversial - despite the absence of evidence to the contrary. Therefore,   
   proposals for the funding of clinical trials have been refused, despite the   
   fact that over 400 unsuccessful clinical trials for Alzheimer's based on other   
   concepts were carried    
   out over a recent 10-year period.    
      
   Opposition to the microbial concepts resembles the fierce resistance to   
   studies some years ago which showed that viruses cause certain types of   
   cancer, and that a bacterium causes stomach ulcers. Those concepts were   
   ultimately proved valid, leading to    
   successful clinical trials and the subsequent development of appropriate   
   treatments.    
      
   Professor Douglas Kell of The University of Manchester’s School of Chemistry   
   and Manchester Institute of Biotechnology is one of the editorial’s authors.   
   He says that supposedly sterile red blood cells were seen to contain dormant   
   microbes, which    
   also has implications for blood transfusions.    
      
   “    
   Professor Douglas Kell    
   We are saying there is incontrovertible evidence that Alzheimer’s Disease   
   has a dormant microbial component, and that this can be woken up by iron   
   dysregulation. Removing this iron will slow down or prevent cognitive   
   degeneration – we can’t keep    
   ignoring all of the evidence.   
   Professor Douglas Kell    
   „    
      
   Professor Resia Pretorius of the University of Pretoria, who worked with   
   Douglas Kell on the editorial, said “The microbial presence in blood may   
   also play a fundamental role as causative agent of systemic inflammation,   
   which is a characteristic of    
   Alzheimer’s disease - particularly, the bacterial cell wall component and   
   endotoxin, lipopolysaccharide. Furthermore, there is ample evidence that this   
   can cause neuroinflammation and amyloid-β plaque formation.”    
      
   The findings of this editorial could also have implications for the future   
   treatment of Parkinson’s Disease, and other progressive neurological   
   conditions.    
      
        
      
   Related    
   Study at the University of Manchester    
   Share this release    
   Landmark editorial identifies microbes as major cause of Alzheimer’s Disease    
      
      
      
   http://www.manchester.ac.uk/discover/news/microbes-as-major-caus   
   -of-alzheimers-disease   
      
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