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   Women with migraines have higher risk of cardiovascular disease, mortality   
   Migraine should be considered an important risk marker for cardiovascular   
   disease, say experts   
   Date:   
   May 31, 2016   
   Source:   
   BMJ   
   Summary:   
   Women diagnosed with migraines have a slightly increased risk of developing   
   cardiovascular diseases, such as heart attacks and strokes, and are somewhat   
   more likely to die from these conditions than women who do not have migraine,   
   according to findings    
   of a large study.   
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   FULL STORY   
   Women diagnosed with migraines have a slightly increased risk of developing   
   cardiovascular diseases, such as heart attacks and strokes, and are somewhat   
   more likely to die from these conditions than women who do not have migraine,   
   according to findings    
   of a large study published in The BMJ today.   
      
   These results add to evidence that migraine should be considered an important   
   risk marker for cardiovascular disease, say experts. But more research is   
   needed to determine possible causes, and whether treatments to prevent   
   migraines could help to reduce    
   these associated risks.   
      
   Migraine has been consistently linked with an increased risk of stroke, but   
   few studies have shown an association of migraine with cardiovascular diseases   
   and mortality.   
      
   So a team of US and German researchers carried out a large prospective study   
   to evaluate associations between migraine, cardiovascular disease and   
   mortality.   
      
   They analysed data from 115,541 women enrolled in the Nurses' Health Study II.   
   The participants were aged 25-42 years, free from angina and cardiovascular   
   disease, and followed from 1989-2011 for cardiovascular events, diseases and   
   mortality.   
      
   Overall, 17,531 (15.2%) women reported a physician's diagnosis of migraine at   
   baseline. Over 20 years of follow-up, 1,329 total cardiovascular disease   
   events occurred and 223 women died due to cardiovascular disease.   
      
   When compared to women who did not have migraine, these results show that   
   women who reported a migraine had a greater risk for major cardiovascular   
   disease, including heart attacks, strokes and angina/coronary re   
   ascularization procedures.   
      
   These associations remained after adjusting for other factors that may have   
   increased the risk for these diseases.   
      
   In addition, migraine was associated with a higher risk for cardiovascular   
   mortality. This association was similar across subgroups of women, including   
   by age, smoking status, hypertension, postmenopausal hormone therapy, and oral   
   contraceptive use.   
      
   In a linked editorial, Rebecca Burch from Harvard Medical School and Melissa   
   Rayhill from The State University of New York at Buffalo caution that "the   
   magnitude of the risk should not be over-emphasized," as "it is small at the   
   level of the individual    
   patient, but still important at a population level because migraine is so   
   prevalent."   
      
   While the current study controlled for a large number of vascular risk   
   factors, no information was available for vascular biomarkers, and migraine   
   specifics, such as migraine aura.   
      
   Nevertheless, the authors say "these results further add to the evidence that   
   migraine should be considered an important risk marker for cardiovascular   
   disease, at least in women," and there is no reason why the findings can't be   
   applicable to men.   
      
   "Given the high prevalence of migraine in the general population, an urgent   
   need exists to understand the biological processes involved and to provide   
   preventive solutions for patients," they conclude.   
      
   The editorialists Rebecca Burch and Melissa Rayhill agree "it's time to add   
   migraine to the list of early life medical conditions that are markers for   
   later life cardiovascular risk."   
      
   They say this latest study raises questions about whether treatments that   
   decrease the frequency or severity of migraine may reduce later life vascular   
   risks, and conclude by saying "what little evidence we do have suggests the   
   need for therapeutic    
   restraint [to prevent cardiovascular risk] until we have a better   
   understanding of the mechanisms underlying the link between migraine and   
   vascular disease."   
      
      
   Story Source:   
      
   The above post is reprinted from materials provided by BMJ. Note: Materials   
   may be edited for content and length.   
      
   Journal Reference:   
      
   Tobias Kurth, Anke C Winter, A Heather Eliassen, Rimma Dushkes, Kenneth J   
   Mukamal, Eric B Rimm, Walter C Willett, JoAnn E Manson, Kathryn M Rexrode.   
   Migraine and risk of cardiovascular disease in women: prospective cohort   
   study. BMJ, 2016; i2610 DOI: 10.   
   1136/bmj.i2610   
   Cite This Page:   
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   BMJ. "Women with migraines have higher risk of cardiovascular disease,   
   mortality: Migraine should be considered an important risk marker for   
   cardiovascular disease, say experts." ScienceDaily. ScienceDaily, 31 May 2016.   
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