From: judgebean23x@gmail.com   
      
   Foundation of Hope   
      
   The Gut Microbiome and Perinatal Mood and Anxiety Disorders (PMAD): A Pilot   
   Study to Examine the Microbiome in Relation to Perinatal Changes in Stress and   
   Immune Systems   
      
   Kimmel 2015Principal Investigator:   Mary C. Kimmel, MD    
      
   Title: The gut microbiome and Perinatal Mood and Anxiety Disorders (PMAD): A   
   pilot study to examine the microbiome in relation to perinatal changes in   
   stress and immune systems   
      
   Need/Problem: PMAD are common and can have grave consequences for mother   
   including a risk of suicide and negative effects on the child’s   
   development.  However, the biologic mechanisms underlying PMAD are unclear.   
   There is evidence that certain gut    
   microbiota are associated with depression and anxious behaviors.   
      
   Grant Summary:  This grant is a novel approach to studying PMAD by studying   
   the microbiota of women across the perinatal period (pregnancy and the   
   postpartum time period) in relation to the development of depression and   
   anxiety.   
      
   Goals & Projected Outcomes: The goal of the study is to collect and analyze   
   the gut microbiota samples in each trimester and 8 weeks postpartum from women   
   with histories of mood and anxiety disorders and women without mood and   
   anxiety disorders.   
      
   Grant Details:   
      
   PMAD are common and have grave consequences for the mother including a risk of   
   suicide and negative effects on the child’s development.  While some   
   mechanisms underlying the development of PMAD have been implicated such as   
   sensitivity to changes in the    
   gonadal steroids and changes in the immune and stress systems, the biological   
   mechanisms remain unclear.   
      
   The gut-brain axis is one possible system that connects the immune system,   
   stress system and the nervous system.  The gut and brain are in constant   
   communication and a major component of the gut is the millions of bacteria and   
   other organisms that live    
   there (the gut microbiota).  There is evidence that certain gut microbiota   
   associate with depression and anxious behaviors in animals as well as two   
   small studies in humans.  During pregnancy the gut microbiota has also been   
   found to change across    
   pregnancy.   
      
   This feasibility study will inform research to study whether the gut   
   microbiota can predict women who will develop PMAD.  In particular, we will   
   test the hypothesis that pro-inflammatory bacteria is more likely associated   
   with PMAD and anti-inflammatory    
   bacteria will be associated with lower risk of developing PMAD.  We will study   
   women at high risk of developing PMAD due to having histories of anxiety and   
   mood disorders and women who do not have histories but still have the general   
   population 1 in 8    
   chance of developing a PMAD.   
      
      
      
      
   http://www.walkforhope.com/current-grants/the-gut-microbiome-and   
   perinatal-mood-and-anxiety-disorders-pmad-a-pilot-study-to-exami   
   e-the-microbiome-in-relation-to-perinatal-changes-in-stress-and-immune-systems/   
      
   --- SoupGate-Win32 v1.05   
    * Origin: you cannot sedate... all the things you hate (1:229/2)