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   Can Probiotics in Yogurt Protect Against Stress and Anxiety?   
   Posted on December 2, 2016   
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   MedicalResearch.com Interview with:   
      
   Elizabeth Bryda, PhD Professor, Director, Rat Resource and Research Center   
   Veterinary Pathobiology University of Missouri Columbia, Missouri   
   Dr. Elizabeth Bryda   
      
   Elizabeth Bryda, PhD   
   Professor, Director, Rat Resource and Research Center   
   Veterinary Pathobiology   
   University of Missouri   
   Columbia, Missouri   
      
   MedicalResearch.com: What is the background for this study? What are the main   
   findings?   
      
   Response: A number of groups have demonstrated the ability of probiotics to   
   benefit digestive health and there is a growing body of evidence to suggest an   
   association between mental health and “gut health”. We were interested to   
   see if probiotic    
   bacteria could decrease anxiety- or stress-related behavior in a controlled   
   setting using zebrafish as our model organism of choice for these studies.   
      
   We were able to show that Lactobacillus plantarum decreased overall   
   anxiety-related behavior and protected against stress-induced dysbiosis   
   (microbial imbalance). The fact that administration of probiotic bacteria also   
   protected other resident gut    
   bacteria from the dramatic changes seen in “stressed” fish not receiving   
   the probiotic was unexpected and suggested that these bacteria may be working   
   at the level of the GI tract and the central nervous system.   
      
      
   MedicalResearch.com: What should readers take away from your report?   
      
   Response: The potential human health implications suggested by our findings   
   are that probiotics such as yogurt may confer some resilience to stress and   
   anxiety, and may also protect the resident gut bacteria from stress- and   
   anxiety-induced disruptions    
   in bacterial community composition.   
      
   MedicalResearch.com: What recommendations do you have for future research as a   
   result of this study?   
      
   Response: There are a couple of “next steps”, some of which are well   
   underway in our lab. We are currently repeating the published study, but with   
   the addition of several treatment groups receiving various compounds capable   
   of blocking different    
   stress-related pathways. These studies are designed to determine the precise   
   mechanisms involved in the protective effects we observed in probiotic-treated   
   zebrafish. We would also like to replicate the key findings in other species   
   such as mice or rats    
   with the long-term goal of moving to translational studies in humans.   
      
   MedicalResearch.com: Is there anything else you would like to add?   
      
   Response: This study underscores the value of a comparative medicine approach   
   to biomedical research, and the selection of an appropriate model species. The   
   University of Missouri has outstanding resources and assets in the field of   
   comparative medicine    
   and is home to the NIH-funded Rat Resource and Research Center (RRRC) and   
   Mutant Mouse Resource and Research Center (MMRRC), a cutting-edge Animal   
   Modeling Core and Metagenomics Center, and a T32-funded training program for   
   veterinarians pursuing    
   specialization in comparative medicine. Drawing from these resources and the   
   combined expertise of classically trained PhD scientists and DVMs with   
   training in comparative medicine allows for robust studies which can quickly   
   be translated to higher    
   vertebrate species before potentially moving to trials in humans.   
      
   MedicalResearch.com: Thank you for your contribution to the Medi   
   alResearch.com community.   
      
   Citation:   
   Lactobacillus plantarum attenuates anxiety-related behavior and protects   
   against stress-induced dysbiosis in adult zebrafish   
   Daniel J. Davis, Holly M. Doerr, Agata K. Grzelak Susheel B. Busi, Eldin   
   Jasarevic, Aaron C. Ericsson&Elizabeth C. Bryda   
      
   Scientific Reports 6, Article number: 33726 (2016)   
   doi:10.1038/srep33726   
      
   Note: Content is Not intended as medical advice. Please consult your health   
   care provider regarding your specific medical condition and questions.   
      
      
      
      
   https://medicalresearch.com/author-interviews/can-probiotics-in-   
   ogurt-protect-against-stress-and-anxiety/30113/   
      
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