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   Memory loss not enough to diagnose Alzheimer’s   
   04   
   Nov, 2016   
      
   Memory loss not enough to diagnose Alzheimer’s   
    Alzheimers   
   Relying on clinical symptoms of memory loss to diagnose Alzheimer’s disease   
   may miss other forms of dementia caused by Alzheimer’s that don’t   
   initially affect memory, reports a new study published in the journal   
   Neurology.   
      
   There is more than one kind of Alzheimer’s disease. Alzheimer’s can cause   
   language problems, disrupt an individual’s behavior, personality and   
   judgment or even affect someone’s concept of where objects are in space. If   
   it affects personality, it    
   may cause lack of inhibition.   
      
   This all depends on what part of the brain it attacks. A definitive diagnosis   
   can only be achieved with an autopsy. Emerging evidence suggests an amyloid   
   PET scan, an imaging test that tracks the presence of amyloid — an abnormal   
   protein whose    
   accumulation in the brain is a hallmark of Alzheimer’s — may be used   
   during life to determine the likelihood of Alzheimer’s disease pathology.   
      
   In the study, the authors identified the clinical features of individuals with   
   primary progressive aphasia (PPA), a rare dementia that causes progressive   
   declines in language abilities due to Alzheimer’s disease. Early on in PPA,   
   memory and other    
   thinking abilities are relatively intact.   
      
   PPA can be caused either by Alzheimer’s disease or another neurodegenerative   
   disease family called frontotemporal lobar degeneration. The presence of   
   Alzheimer’s disease was assessed in this study by amyloid PET imaging or   
   confirmed by autopsy.   
      
   The study demonstrates that knowing an individual’s clinical symptoms   
   isn’t sufficient to determine whether someone has PPA due to Alzheimer’s   
   disease or another type of neurodegenerative disease. Therefore, the authors   
   say, biomarkers, such as    
   amyloid PET imaging, are necessary to identify the neuropathological cause.   
      
   Paper: “Aphasic variant of Alzheimer disease”   
   Reprinted from materials provided by Northwestern University.   
      
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   nough-to-diagnose-alzheimers/   
      
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