From: mjs23x@gmail.com   
      
   On Sunday, March 1, 2015 at 5:30:05 PM UTC-6, ⊙＿⊙ wrote:   
   > Alzheimer's Disease, Schizophrenia Related to Common Brain Regions   
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   > A network of brain regions is vulnerable to unhealthy developmental and   
   aging processes, including Alzheimer's disease and schizophrenia, according to   
   an analysis of brain structural variation in 484 healthy people. Results were   
   published recently in    
   the Proceedings of the National Academy of Sciences.   
   >    
   > "Our results suggest that the common spatial pattern of abnormalities   
   observed in these two disorders, which emerge at opposite ends of the life   
   spectrum, might be influenced by the timing of their separate and distinct   
   pathological processes in    
   disrupting healthy cerebral development and aging, respectively," the   
   researchers wrote.   
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   > In this study, the researchers examined structural brain images of 220 males   
   and 264 females between 8 and 85 years old who underwent the same imaging   
   protocol. They used a linked independent component analysis, which they noted   
   allowed them to see    
   images in spatial components and evaluate the variations in brain structures.   
   >    
   > By identifying the brain network, the researchers said they could examine   
   vulnerabilities to disorders that impact brain structure during adolescence   
   and aging. They found that the inverted-U component of the brain closely   
   resembled the gray matter    
   regions, showed accelerated atrophy of Alzheimer's disease, and matched   
   regions that showed an altered developmental trajectory in adolescent-onset   
   schizophrenia.   
   >    
   > Females had a significantly higher and slightly later peak with age compared   
   with males, according to the inverted-U component analysis. The researchers   
   said that finding could be related to the later age of onset of symptoms in   
   women with Alzheimer's    
   disease and schizophrenia.   
   >    
   > Although the results may be surprising, the researchers noted that previous   
   studies indicated Alzheimer's disease and schizophrenia are both linked to a   
   selective damage to the heteromodal cortex of the brain.   
   >    
   > "Using a data-driven approach, we have therefore been able to characterize a   
   biologically meaningful component intrinsically linking late development,   
   early degeneration, and vulnerability to disease," the researchers wrote.   
   "There is mounting evidence    
   that the pattern of various brain disorders can be explained to some extent by   
   observing the healthy brain."   
   >    
   > --Tim Casey   
   >    
   > Reference   
   >    
   > 1. Douaud G, Groves A, Tamnes C, et al. A common brain network links   
   development, aging, and vulnerability to disease. Proceedings of the National   
   Academy of Sciences. 2014 November 24;[Epub ahead of print].   
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   > http://www.psychcongress.com/article/alzheimer's-disease-schiz   
   phrenia-related-common-brain-regions-20251   
      
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