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   Common painkiller 'could help prevent premature ageing': Ibuprofen can help   
   diabetes and dementia patients from growing old before their time   
      
   The popular over the counter painkiller gave ageing mice a new lease of life   
   Could help patients with age-related illnesses diabetes and dementia   
   While it's unlikely to improve illness, drug might slow its progression   
      
   By Fiona Macrae for the Daily Mail   
   PUBLISHED: 20:45 EDT, 24 June 2014 | UPDATED: 06:48 EDT, 25 June 2014   
      
   It already works wonders on pounding headaches. But ibuprofen could also hold   
   the secret to a long and healthy life	+3   
   It already works wonders on pounding headaches. But ibuprofen could also hold   
   the secret to a long and healthy life   
   It already works wonders on pounding headaches.    
   But ibuprofen could also hold the secret to a long and healthy life.   
   In a series of remarkable experiments, the popular painkiller gave ageing mice   
   a new lease of life.   
   Researchers from Newcastle University say it might help people with   
   age-related illnesses such as diabetes and dementia from growing old before   
   their time.   
   While it is unlikely to improve their illness, the inexpensive drug might slow   
   its progression – and help prevent them from developing other debilitating   
   conditions.   
   As surprising as this might seem, researcher Thomas von Zglinicki said it is   
   not unusual for a drug that is developed to treat one thing to have other   
   powers.   
   At the heart of Professor von Zglinicki’s theory is the inflammation that   
   causes pain, swelling and fever we experience when our body is fighting off an   
   infection.   
   This inflammation is also present in a milder but longer-term form in   
   age-related diseases such as diabetes, dementia and arthritis.   
   Using GM mice, the professor showed that far from being a result of ageing,   
   this inflammation helps drive it. Mice with genes that made them particularly   
   prone to inflammation aged twice as quickly as normal animals.   
   Just like people, their hair turned grey and fell out, they lost weight,   
   became unsteady on their feet and had heart problems. They also lived half as   
   long as usual.   
   Scroll down for video   
   In a series of remarkable experiments, the popular painkiller gave ageing mice   
   a new lease of life	+3   
   In a series of remarkable experiments, the popular painkiller gave ageing mice   
   a new lease of life   
   An animated guide to how Ibuprofen relieves pain   
      
   Tests showed that the inflammation triggered a chain of reactions that led to   
   cells going to sleep, rather making new copies needed to help keep the body   
   and its organs young.   
   Treating the mice with ibuprofen stopped the cells from going into this   
   sleeping state.    
   Plus, the animals were able to repair damage to their liver, the journal   
   Nature Communications reports.   
      
   Professor von Zglinicki said mice were ‘basically brought back to normal’.   
   He is now checking if the treatment also extends lifespan.   
   Ibuprofen is taken by up to nine million Britons a day to treat headaches,   
   muscle pain, sprains and flu.    
   But it can also cause indigestion and stomach ulcers, while higher doses taken   
   long-term for conditions such as arthritis can raise the risk of strokes and   
   heart attacks, and even reduce a woman’s fertility.   
   Ibuprofen risks.jpg	+3   
   While the professor says that regular ibuprofen might help people with   
   age-related illnesses such as dementia and diabetes, he advises them to talk   
   to their GP first before starting self-medication.   
   They should also ask their doctor to do a simple blood test to confirm they   
   are a victim of mild but persistent inflammation.   
   ‘The hope is not really that it will improve the illness that they have but   
   that it might slow the progression,’ he said.   
   Ibuprofen is unlikely to help those who are healthy but would simply like to   
   slow the ageing process – in the experiments, it had no effect on mice that   
   were ageing normally.   
   The professor said: ‘Long-term drug use is something one has to think about   
   and we cannot justify it in healthy people when the data don’t give us a   
   strong basis.’   
   In the meantime, he suggests that those keen to stay young try to keep a lid   
   on inflammation by eating foods that might help combat it, such as blueberries.   
   Dr Lynne Cox, an ageing expert at Oxford University, called the research ‘a   
   lovely piece of science’.   
   However, she said side-effects associated with long-term use of ibuprofen are   
   so serious that people should not take it just to keep them young.   
       
      
      
   Read more: http://www.dailymail.co.uk/health/article-2668602/Com   
   on-painkiller-help-prevent-premature-ageing-Ibuprofen-help-diabe   
   es-dementia-patients-growing-old-time.html#ixzz4f9EYovIx    
      
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