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   White matter abnormalities in female interstitial cystitis   
      
   June 20, 2015   
      
    White matter abnormalities in female interstitial cystitis   
   (HealthDay)—Women with interstitial cystitis/bladder pain syndrome have   
   white matter abnormalities, according to a study published in the July issue   
   of The Journal of Urology.   
      
      
   Melissa A. Farmer, Ph.D., from the Northwestern University Feinberg School of   
   Medicine in Chicago, and colleagues administered questionnaires on pain, mood,   
   and daily function to 34 women with interstitial cystitis/bladder pain   
   syndrome and 32 healthy    
   controls. Diffusion tensor imaging that models directional water flow along   
   axons or fractional anisotropy was used to evaluate white matter   
   microstructure.   
      
   The researchers observed numerous white matter abnormalities that correlated   
   with pain severity, urinary symptoms, and impaired quality of life among women   
   with interstitial cystitis/bladder pain syndrome. Decreased fractional   
   anisotropy in aspects of    
   the right anterior thalamic radiation, the left forceps major, and the right   
   longitudinal fasciculus characterized interstitial cystitis/bladder pain   
   syndrome. In the right superior and bilateral inferior longitudinal fasciculi   
   the researchers detected    
   increased fractional anisotropy.   
      
   "To our knowledge we report the first characterization of brain white matter   
   abnormalities in women with interstitial cystitis/bladder pain syndrome," the   
   authors write. "Given that white matter abnormalities closely correlated with   
   hallmark symptoms of    
   interstitial cystitis/bladder pain syndrome, including bladder pain and   
   urinary symptoms, brain anatomical alterations suggest that there are   
   neuropathological contributions to chronic urological pelvic pain."   
      
   Two authors disclosed financial ties to the pharmaceutical industry.   
      
      
       
   More information: Abstract    
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   https://m.medicalxpress.com/news/2015-06-white-abnormalities-fem   
   le-interstitial-cystitis.html   
      
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