From: here@is.invalid   
      
   COVID-19 Breakthrough: Scientists Discover How the SARS-CoV-2 Virus   
   Evades Our Immune System   
      
   The underlying mechanism of how SARS-CoV-2 escapes from the immune   
   system has been poorly understood. However, researchers from the Texas   
   A&M University College of Medicine and Hokkaido University have   
   recently discovered a major mechanism that explains how SARS-CoV-2 can   
   escape from the immune system and replicate in the human body. Their   
   findings were recently published in the journal Nature Communications.   
      
   "We found that the SARS-CoV-2 virus carries a suppressive gene that   
   acts to inhibit a human gene in the immune system that is essential   
   for destroying infected cells," said Dr. Koichi Kobayashi, adjunct   
   professor at the College of Medicine and lead author of the paper.   
      
   Naturally, the cells in a human's immune system are able to control   
   virus infection by destroying infected cells so that the virus cannot   
   be replicated. The gene that is essential in executing this process,   
   called NLRC5, regulates major histocompatibility complex (MHC) class I   
   genes, which are genes that create a pathway that is vital in   
   providing antiviral immunity. Kobayashi and his colleagues discovered   
   this in 2012.   
      
   "During infection, the amount and activity of NLRC5 gene become   
   augmented in order to boost our ability of eradication of viruses,"   
   Kobayashi said. "We discovered that the reason why SARS-CoV-2 can   
   replicate so easily is because the virus carries a suppressive gene,   
   called ORF6, that acts to inhibit the function of NLRC5, thus   
   inhibiting the MHC class I pathway as well."   
   ...   
   ...   
   "We hope that this new discovery will allow us to develop a new drug   
   that can block this gene so our immune system will be able to fight   
   off the coronavirus for good," de Figueiredo said.   
      
   https://scitechdaily.com/covid-19-breakthrough-scientists-discov   
   r-how-the-sars-cov-2-virus-evades-our-immune-system/   
      
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