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   Message 53,625 of 55,615   
   yyy378 to durabol74@gmail.com   
   Re: Reduction with Sodium Borohydride   
   03 Jul 15 16:43:35   
   
   From: donotsentjunk@hotmail.com   
      
   On 03/07/2015 14:27, durabol74@gmail.com wrote:   
   > This reaction takes place in methanol and slowly over 1 hour sodium   
   borohydride is stirred in. Since heat is generated I assume the sodium   
   borohydride reacts with the methanol as the reduction takes place but I am   
   unsure if this is correct? If it doesn'   
   t react with the methanol it would be nice if I could dissolve the sodium   
   borohydride in methanol and use a dropping funnel. I have read that the   
   reduction can also be done with lithium aluminum hydride or sodium, which   
   might be a better way to go, but I    
   don't have much for details on these other options.   
   >   
   > Brock   
   >   
      
   Sodium borohydride reacts with methanol. The reaction is completed in 90   
   minutes (in the presence of excess of methanol). But if you want to use   
   it to reduce aldehyde or ketone, whose reactions are quite fast,   
   methanol is typically the choice of solvent.   
      
   LAH and sodium are stronger reducing agents. Depending on what other   
   functional groups are present, you may or may not be able to use them.   
      
   Use sodium borohydride if you can because it is fast and workup is   
   simple. LAH very often gives an emulsion during workup.   
      
   --- SoupGate-Win32 v1.05   
    * Origin: you cannot sedate... all the things you hate (1:229/2)   

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