From: poutnik4nntp@gmail.com   
      
   Dne 17/10/2015 v 06:58 durabol74@gmail.com napsal(a):   
   > I don't consider myself a Chemist but I've been trying to studying   
   > Grignard reactions in order to add to a carbonyl group(CH3) in place   
   > of a ketone(=O) using methylmagnesium bromide. The common solvent for   
   > this reaction is pyridine and I've also read that sometimes a mixture   
   > of acetone and pyridine is used. Using acetone surprised me since I   
   > thought that acetone is a ketone and may interfere with the reaction?   
   > Anyway perhaps acetone doesn't interfere so I'm wondering if just   
   > acetone could be used or does pyridine have a special role? Any   
   > Chemists out there with enlightenment?   
   > Brock   
   >   
   I am not an organic chemist, but in my understanding acetone   
   as an carbonyl compound does react with Grignard reagents.   
      
   CH3-CO-CH3 + R-Mg-X --> (CH3)2-CR-O-MgX   
   (CH3)2-CR-O-MgX + H+  --H2O----> (CH3)2-CR-OH + 2Mg2+ 2 X-   
      
   https://en.wikipedia.org/wiki/Grignard_reaction#With_carbonyl_compounds   
      
   In my understanding, Grignard reacts with electrofil groups like   
   carbonyls, not with nucleofil structures of heteroaromatics.   
      
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