From: patrizio.pan-2002@libero.it   
      
   Il giorno sabato 17 ottobre 2015 06:58:35 UTC+2, dura...@gmail.com ha scritto:   
   > I don't consider myself a Chemist but I've been trying to studying   
   > Grignard reactions in order to add to a carbonyl group(CH3) in place   
   > of a ketone(=O) using methylmagnesium bromide. The common solvent for   
   > this reaction is pyridine and I've also read that sometimes a mixture   
   > of acetone and pyridine is used. Using acetone surprised me since I   
   > thought that acetone is a ketone and may interfere with the reaction?   
   > Anyway perhaps acetone doesn't interfere so I'm wondering if just   
   > acetone could be used or does pyridine have a special role? Any   
   > Chemists out there with enlightenment?   
      
   Most improbable IMHO.   
      
   Reaction of a typical Grignard reagent (MeMgBr is) with an   
   unencumbered ketone (acetone is) is a standard case, the   
   main scope so to say.   
      
   Perhaps at very, very low temps the reaction with acetone   
   could be slowed down or even be frozen. If the purpose was   
   a reaction of a Grignard reagent with a much more reactive   
   carbonyl compound, such for example a carbonyl chloride   
   (R-CO-Cl, a more electrophilic group), the presence of   
   acetone could not interfere (though I don't see why it   
   should be of any help).   
      
   > Brock   
      
   regards   
   Angelo   
      
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