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|    sci.chem    |    Chemistry and related sciences    |    55,615 messages    |
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|    Message 54,975 of 55,615    |
|    Treon Verdery to All    |
|    study looking at fruit flies, lutein pro    |
|    13 Aug 22 22:22:49    |
      From: treon3verdery@gmail.com              A journal article mentions several DNA repair mechanisms, such as base       excision repair (BER), nucleotide excision repair (NER), transcription-coupled       repair (TCR), homologous recombination, nonhomologous end-joining (NHEJ), and       telomere elongation, as a        longevity technology an epigenetic RNA drug or other epigenetic that       upregulates these mechanisms/proteins could be measured as to longevity       increase in age batched groups of human volunteers, also, considering each DNA       repair enzyme as part of a network        there are possible network proteins and genes that reduce their amount or       activity, knocking out those network repair decreaser genes or also       epigenetically downregulating the decreasers can be measured as to possible       longevity and tissue youthfulness        effects at mice and marmosets              Searching for an existing deleterious physiochemical cascade network then       epigenetically downregulating it: repair diminishers, what if they have more       than one function, more than one of which is deleterious, make an ordered list       of largest number of        deleterious actions of one gene/chemical for many genes and physiochemicals,       so that genes that do a larger plurality of negative things each can be       shortlisted, epigenetic downregulation of the production of those deleterious       gene's physiochemicals        would create one multiply beneficial longevity and wellness epigenetic drug;       most things that build muscle are delongevizing so epigenetic hypermethylation       of the top of the short list of body produced muscle building physiochemicals       with the largest        number of immediate or downstream sequelae is a new area of longevity drugs              New epigenetic drugs that precisely locate on the acetylation-ome and       methylome epigenetic maps and make their epigenetic changes effectively, RNA       epigenetic drugs with high site specificity exist, i think, so synthetic       ribonucleic acids that are        nonmetabolized, so persist thousands of times longer, increased chemical       ability to donate a methyl group or acetyl group, are possibly a nuclear       membrane transport facilitating peptide linked to the synthetic nucleotide,       overlay stencil, photonically        activateable, dwell time from deuteration could increase giving longer moments       for the methyl or acetyl group to attach, or at epigenetric drugs that remove       a mark halogenated or Mg containing synthetic nucleotide sequences could glom       away existing        epigenetic marks from the halogen or metal giving the synthetic amino acid       much greater charge concentration at useful places              Lutein makes flies live 63% longer and concentrates in the occipital lobe       which could be a great place to put nootropics and general simulants, an even       higher level of visual instanteous memory and as wikipedia says, "ventral       stream is known for        processing the "what" in vision, while the dorsal stream handles the       "where/how." This is because the ventral stream provides important information       for the identification of stimuli that are stored in memory. With this       information in memory, the dorsal        stream is able to focus on motor actions in response to the outside stimuli."       So as a nootropic phenylpiracetam molecularly linked to lutein would seek out       just the particular area, the occipital lobe, that informs instant       nonnarrative consciousness as        well as narrative consciousness about what a thing is, that is a what a thing       is in relation to entire life experience, this could be a valued drug for       people, perhaps older people looking through a high school yearbook and       recognizing a face 40% more is        possible and fun              Improving virtual reality with visual evoked potential measurement that finds       greatest 3Dness and optimal brightness level, single electrode on a eeg head       circlet measures visual evoked potentials and calibrates VR gear, such as with       me the ratio of        right and left proportions of viewing with polarized light shutter glasses                     [continued in next message]              --- SoupGate-Win32 v1.05        * Origin: you cannot sedate... all the things you hate (1:229/2)    |
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