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   sci.chem      Chemistry and related sciences      55,615 messages   

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   Message 54,975 of 55,615   
   Treon Verdery to All   
   study looking at fruit flies, lutein pro   
   13 Aug 22 22:22:49   
   
   From: treon3verdery@gmail.com   
      
   A journal article mentions several DNA repair mechanisms, such as base   
   excision repair (BER), nucleotide excision repair (NER), transcription-coupled   
   repair (TCR), homologous recombination, nonhomologous end-joining (NHEJ), and   
   telomere elongation, as a    
   longevity technology an epigenetic RNA drug or other epigenetic that   
   upregulates these mechanisms/proteins could be measured as to longevity   
   increase in age batched groups of human volunteers, also, considering each DNA   
   repair enzyme as part of a network    
   there are possible network proteins and genes that reduce their amount or   
   activity, knocking out those network repair decreaser genes or also   
   epigenetically downregulating the decreasers can be measured as to possible   
   longevity and tissue youthfulness    
   effects at mice and marmosets   
      
   Searching for an existing deleterious physiochemical cascade network then   
   epigenetically downregulating it: repair diminishers, what if they have more   
   than one function, more than one of which is deleterious, make an ordered list   
   of largest number of    
   deleterious actions of one gene/chemical for many genes and physiochemicals,   
   so that genes that do a larger plurality of negative things each can be   
   shortlisted, epigenetic downregulation of the production of those deleterious   
   gene's physiochemicals    
   would create one multiply beneficial longevity and wellness epigenetic drug;   
   most things that build muscle are delongevizing so epigenetic hypermethylation   
   of the top of the short list of body produced muscle building physiochemicals   
   with the largest    
   number of immediate or downstream sequelae is a new area of longevity drugs   
      
   New epigenetic drugs that precisely locate on the acetylation-ome and   
   methylome epigenetic maps and make their epigenetic changes effectively, RNA   
   epigenetic drugs with high site specificity exist, i think, so synthetic   
   ribonucleic acids that are    
   nonmetabolized, so persist thousands of times longer, increased chemical   
   ability to donate a methyl group or acetyl group, are possibly a nuclear   
   membrane transport facilitating peptide linked to the synthetic nucleotide,   
   overlay stencil, photonically    
   activateable, dwell time from deuteration could increase giving longer moments   
   for the methyl or acetyl group to attach, or at epigenetric drugs that remove   
   a mark halogenated or Mg containing synthetic nucleotide sequences could glom   
   away existing    
   epigenetic marks from the halogen or metal giving the synthetic amino acid   
   much greater charge concentration at useful places   
      
   Lutein makes flies live 63% longer and concentrates in the occipital lobe   
   which could be a great place to put nootropics and general simulants, an even   
   higher level of visual instanteous memory and as wikipedia says, "ventral   
   stream is known for    
   processing the "what" in vision, while the dorsal stream handles the   
   "where/how." This is because the ventral stream provides important information   
   for the identification of stimuli that are stored in memory. With this   
   information in memory, the dorsal    
   stream is able to focus on motor actions in response to the outside stimuli."   
   So as a nootropic phenylpiracetam molecularly linked to lutein would seek out   
   just the particular area, the occipital lobe, that informs instant   
   nonnarrative consciousness as    
   well as narrative consciousness about what a thing is, that is a what a thing   
   is in relation to entire life experience, this could be a valued drug for   
   people, perhaps older people looking through a high school yearbook and   
   recognizing a face 40% more is    
   possible and fun   
      
   Improving virtual reality with visual evoked potential measurement that finds   
   greatest 3Dness and optimal brightness level, single electrode on a eeg head   
   circlet measures visual evoked potentials and calibrates VR gear, such as with   
   me the ratio of    
   right and left proportions of viewing with polarized light shutter glasses   
      
      
   [continued in next message]   
      
   --- SoupGate-Win32 v1.05   
    * Origin: you cannot sedate... all the things you hate (1:229/2)   

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