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|    sci.chem    |    Chemistry and related sciences    |    55,615 messages    |
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|    Message 54,981 of 55,615    |
|    Treon Verdery to All    |
|    Lactoferrin variants and other antimicro    |
|    13 Aug 22 22:35:54    |
      From: treon3verdery@gmail.com              specific pathogen free mice are published as living twice as long and specific       pathogen free marmosets live 18% longer, so producing physiologically harmless       antimicrobial peptides at the human (Homo sapiens and branch species) germline       genome that        creates a functionalike to specific pathogen free humans could be a double       digit lifespan increasing longevity technology that also increases wellness              New synthetic higher antimicrobial lactoferrin veriants are published, making       these into Y shaped tripeptide drugs or even * dendritic drugs could increase       their effectiveness              Synthetic lactoferrins and other antimicrobial drugs could be made with a       fusion gene, whereever the base gene gets lots more productive activity during       illness, perhaps puffiness, erythema, and encapsulation responses can be       traced to gene expression,        and then those genes made into fusion genes with DNA sequences that make       improved synthetic lactoferrins, creating a system where if any cells are       reacting to local illness they make synthetic lactoferrins locally              Beneficial lactoferrins are a prominent protein in breastmilk, and have been       engineered into much more potent antimicrobial and antitumor forms, so perhaps       at other species feeding babies is associated with beneficial peptide and       protein transfer, that        can with research be made into human drugs, one place to look is bird mouth       saliva and stomach contents, as the feeding bird regurgitates food into the       mouth of its young, bees also do regurgitation feeding of young, also new       greenleaf growth on a        perennial could be associated with antipathogen antimicrobial, and antifungal       and antiviral plant produced chemicals, some of which might be very different       than peptides and proteins, these plant antimicrobials could possibly be found       in or near stomata        where there is a continuous mucous membrane like access to the interior of the       leaf, another source of antimicrobials could be marsupial pouch milk, and even       just the interior of marsupial pouches, at fish that are mouthbearers the       mouth of the female        fish may contain mucous with chemicals that are antimicrobial and benefit the       baby fish              Double decker pallets for within-container container shipping, maybe,       visualize a 90 degree angle made of variable height metal or polymer slats       have it fit into slots on the base pallet, then put another pallet on top of       it, fitting the vertical slats        into the slot, with a pole insertable at the 4th unconnected corner to give 4       corners of support, this causes an unswaying 2 layer pallet stack that a robot       can easily grasp and take apart with electromagnet manipulators, the advantage       of double height 2        pallet stacks is being able to transport 60% more goods per container ship and       container, other geometries are also possible              Longevity technology, finding the 99th percentile of deleterious proteins, and       the 99th percentile of most longevity beneficial proteins at humans (Homo       sapiens and branch species) by doing all-human tissue homogenate,       electrophoresis, then enteric        coating the proteins and peptides to feed them, in a fractional factorial       matrix dosing experiment to 96 well plate fish like zebrafish, 20K human (Homo       sapiens and branch species) genes make 20K proteins but its my perception the       number of different        proteins at a human (Homo sapiens and branch species is longer than that, so       at a fractional factorial matrix experiment that feeds four different protein       electrophoresis gel lines to fish simultaneously then as few as 5000 zebrafish       or 9 month lifespan        mini-fish can be used, at 59ยข/24 hours, $149 per 9 months/fish, this may be       an order of magnitude less expense overseas like in China to make it $14.9 per       fish, at 5000 fish this is $75,000 for enough fish, eating every singular       electrophoretic        fraction protein gel line as an enteric coated thing at their multiple times       per day feeding, to find the 99th percentile of deleterious proteins and the       99th percentile of beneficial proteins, then at mice, epigenetically       upregulate the 200 most        beneficial proteins genes simultaneously, then have a group of epigenetically       downregulating the 200 most deleterious genes, then have a group with both       simultaneous epigenetic upregulation and downregulation, also do this to human       tissue cultures        verifying their longevization as well as the longevization of the mice, this       produces a suite of 200-400 epigenetic RNA drugs that longevizes humans and       increases wellness, the epigenetic drug suite can be airjected in depot form       at the human (Homo        sapiens and branch species) body so it lasts long enough to make epigenetic       changes              Social companion robots and other robots, at a polymer surface could have       microtubes through which exterior things can pass through, a design with a       uvula flap or wiggly channel has an ultrasonic frequency that wiggles the       exterior material to the robot        interior, and a resonant frequency in ultrasound that drives material the       other way out the channel, invisible to humans ultrasonically resonating       channels pump chemicals from the surface to the interior where they are       characterized, analogous to taste        and smell              Social companion robots skin is white, but can simultaneously have minute       micrometer sized transparent optical channels, actual vertical transparent       likely polymer pillars, in it, making the entire inner surface of the       companion robot suitable for having        plural cameras on it, from nonvisible to humans ordered transparency                     [continued in next message]              --- SoupGate-Win32 v1.05        * Origin: you cannot sedate... all the things you hate (1:229/2)    |
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