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   sci.chem      Chemistry and related sciences      55,615 messages   

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   Message 54,981 of 55,615   
   Treon Verdery to All   
   Lactoferrin variants and other antimicro   
   13 Aug 22 22:35:54   
   
   From: treon3verdery@gmail.com   
      
   specific pathogen free mice are published as living twice as long and specific   
   pathogen free marmosets live 18% longer, so producing physiologically harmless   
   antimicrobial peptides at the human (Homo sapiens and branch species) germline   
   genome that    
   creates a functionalike to specific pathogen free humans could be a double   
   digit lifespan increasing longevity technology that also increases wellness   
      
   New synthetic higher antimicrobial lactoferrin veriants are published, making   
   these into Y shaped tripeptide drugs or even * dendritic drugs could increase   
   their effectiveness   
      
   Synthetic lactoferrins and other antimicrobial drugs could be made with a   
   fusion gene, whereever the base gene gets lots more productive activity during   
   illness, perhaps puffiness, erythema, and encapsulation responses can be   
   traced to gene expression,    
   and then those genes made into fusion genes with DNA sequences that make   
   improved synthetic lactoferrins, creating a system where if any cells are   
   reacting to local illness they make synthetic lactoferrins locally   
      
   Beneficial lactoferrins are a prominent protein in breastmilk, and have been   
   engineered into much more potent antimicrobial and antitumor forms, so perhaps   
   at other species feeding babies is associated with beneficial peptide and   
   protein transfer, that    
   can with research be made into human drugs, one place to look is bird mouth   
   saliva and stomach contents, as the feeding bird regurgitates food into the   
   mouth of its young, bees also do regurgitation feeding of young, also new   
   greenleaf growth on a    
   perennial could be associated with antipathogen antimicrobial, and antifungal   
   and antiviral plant produced chemicals, some of which might be very different   
   than peptides and proteins, these plant antimicrobials could possibly be found   
   in or near stomata    
   where there is a continuous mucous membrane like access to the interior of the   
   leaf, another source of antimicrobials could be marsupial pouch milk, and even   
   just the interior of marsupial pouches, at fish that are mouthbearers the   
   mouth of the female    
   fish may contain mucous with chemicals that are antimicrobial and benefit the   
   baby fish   
      
   Double decker pallets for within-container container shipping, maybe,   
   visualize a 90 degree  angle made of variable height metal or polymer slats   
   have it fit into slots on the base pallet, then put another pallet on top of   
   it, fitting the vertical slats    
   into the slot, with a pole insertable at the 4th unconnected corner to give 4   
   corners of support, this causes an unswaying 2 layer pallet stack that a robot   
   can easily grasp and take apart with electromagnet manipulators, the advantage   
   of double height 2    
   pallet stacks is being able to transport 60% more goods per container ship and   
   container, other geometries are also possible   
      
   Longevity technology, finding the 99th percentile of deleterious proteins, and   
   the 99th percentile of most longevity beneficial proteins at humans (Homo   
   sapiens and branch species) by doing all-human tissue homogenate,   
   electrophoresis, then enteric    
   coating the proteins and peptides to feed them, in a fractional factorial   
   matrix dosing experiment to 96 well plate fish like zebrafish, 20K human (Homo   
   sapiens and branch species) genes make 20K proteins but its my perception the   
   number of different    
   proteins at a human (Homo sapiens and branch species is longer than that, so   
   at a fractional factorial matrix experiment that feeds four different protein   
   electrophoresis gel lines to fish simultaneously then as few as 5000 zebrafish   
   or 9 month lifespan    
   mini-fish can be used, at 59ยข/24 hours, $149 per 9 months/fish, this may be   
   an order of magnitude less expense overseas like in China to make it $14.9 per   
   fish, at 5000 fish this is $75,000 for enough fish, eating every singular   
   electrophoretic     
   fraction protein gel line as an enteric coated thing at their multiple times   
   per day feeding, to find the 99th percentile of deleterious proteins and the   
   99th percentile of beneficial proteins, then at mice, epigenetically   
   upregulate the 200 most    
   beneficial proteins genes simultaneously, then have a group of epigenetically   
   downregulating the 200 most deleterious genes, then have a group with both   
   simultaneous epigenetic upregulation and downregulation, also do this to human   
   tissue cultures    
   verifying their longevization as well as the longevization of the mice, this   
   produces a suite of 200-400 epigenetic RNA drugs that longevizes humans and   
   increases wellness, the epigenetic drug suite can be airjected in depot form   
   at the human (Homo    
   sapiens and branch species) body so it lasts long enough to make epigenetic   
   changes   
      
   Social companion robots and other robots, at a polymer surface could have   
   microtubes through which exterior things can pass through, a design with a   
   uvula flap or wiggly channel has an ultrasonic frequency that wiggles the   
   exterior material to the robot    
   interior, and a resonant frequency in ultrasound that drives material the   
   other way out the channel, invisible to humans ultrasonically resonating   
   channels pump chemicals from the surface to the interior where they are   
   characterized, analogous to taste    
   and smell   
      
   Social companion robots skin is white, but can simultaneously have minute   
   micrometer sized transparent optical channels, actual vertical transparent   
   likely polymer pillars, in it, making the entire inner surface of the   
   companion robot suitable for having    
   plural cameras on it, from nonvisible to humans ordered transparency   
      
      
   [continued in next message]   
      
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