From: treon3verdery@gmail.com   
      
   Do enzymes make or regenerate NMN at the body?  Genes for these could have   
   SNPs that are high wellness phenotypes, gene therapy could be a wellness   
   drug.  Although NMN only made mice live 5% longer further study might find a   
   longevity effect, notably    
   from cardiowellnes and perhaps youthful liver function at removing xenobiotics   
   and reducing cancer,   
      
   Are there naturally occuring body produced chemicals that contributed to more   
   than half of 20th century cancers? (with the idea that xenobiotics, stress,   
   possibly EM, sedentariness and food might have caused much of the rest)  SNPs   
   about these body    
   occuring carcinogenic chemicals could be anti-cancer gene variations that   
   people could optimize with genetic engineering and gene therapy. Insulin and   
   growth factor genetics are possibilities, as is possibly sex hormone levels   
   and SHBG (plasma fraction    
   that gloms steroids); I think there are published systems approaches as well,   
   like mRNA math distribution change with physiological challenges,   
   epigenenetics, and mitochondrial number change.   
      
   Longevity chemical:  It is my perception that some cytes have less than a   
   dozen mitochondria, and other sites might have near 400;  If you do gene   
   therapy or modify the human genome to have mRNA for proteins that would   
   otherwise be affected as to their    
   amount from having fewer mitochondria per cyte from chronological duration   
   effects produced at those cytes (and tissues) that have upper third of   
   mitochondrial number quantity does more of the previously diminishing protein   
   get produced, thus benefitting    
   the body and causing youthful levels of protein to exist?  Some proteins   
   travel from cyte to cyte as neighbors as well as circulate at the circulatory   
   system, the proteins that travel outside the cyte could be especially   
   engineering effective at sharing    
   benefit from the gene-therapied, many-mitochondiad cytes and tissues.     
      
   Genetic engineering biochemicals to be mRNA coded or produced at the ADP makes   
   ATP cycle, which processes 90 lbs of ADP every 24 hours looks like higher   
   volume production.   
      
   I think the ethics and engineering of making humanly intended (mind) physical   
   or possibly neural activation alone, actions modify genetic expression and   
   thus phenotype support the beneficial use of this technology.  Prior to 2019   
   AD and I think anytime,    
   It would have been nice and beneficial, and not that much effort if people had   
   the ability to modify the output of their genes and voluntarily modify their   
   phenotype from simple purposed actions.  Things like skipping a day of food,   
   drinking a gallon of    
   water, or recieving a two hour pleasant massage could all be adressable gene   
   switches to turn on beneficial effects while being just slightly unusual   
   enough to omit unintentional activation.  Would you like your beautiful   
   personally appreciated hair to    
   grow twice as fast?  Get a two hour massage once every 6 months. Getting a   
   massage, even massage at a specific body part to get a specific gene   
   activating phenotypic effect is a possible way to adjust pehnotype voluntarily   
   at the individual, without    
   medical, chemical, social, or fiscally-linked activity based actions.  You can   
   give yourself a massage, become more socially fluent and have more fun. It is   
   highly valuable to have previously heightened cognitive ability at all   
   persons, people, humans to    
   higher amount, I think genetically engineering persons, humans, that is people   
   at the germline and thus phenotype to be three, four, or five times more   
   intelligent than I am, with the persons, people, that is humans having the   
   ability to make their    
   beings more intelligent from that is beneficial and more optimal.   
      
   Another possibility is a minimal amount of exercise, possibly with different   
   muscles switching on or off different genes, like if you prefer more   
   responsive dopamine receptors (more fun!) then walk more. This increases the   
   amount of mitochondria, the    
   protein production of the cytes, and possibly the actual number of muscle   
   cytes as well.  Technologically among the things are the gene therapy or   
   modified human genome concentrating the production of biochemicals or also   
   proteins that can circulate, or    
   possibly things like neuron-localized nerve growth factors produced at muscle   
   that then increase growth of doapmine neurons. (the thighs, but only the   
   thighs produce a chemical, that when it circulates increases a growth factor   
   like NGF or BDNF at just    
   dopamine neurons)  So walking exercises the thighs, and that produces   
   chemicals that cause the brain’s phenotype to improve to have more dopamine   
   responsiveness and more dopamine.  If you prefer less dopamine you could do   
   sit-ups.  wlaking is easier    
   than sit-ups, to my perception, so people with this intentionally changeable   
   phenotype genetic form might sort of have an automatic happiness fun   
   physiological tenedency,although just genetically engineering people and   
   germlines to be much happier is    
   beneficial and I support Dave Pearce’ hedonistic Imperative.   
      
      
   As an early 21st century longevity technology, producing more mitochondria,   
   whether with chemicals, gene therapy, germline modification, or exercise,   
   might increase the production of other proteins at the cytes from simply   
   making more mitochondria, which    
   makes more ATP available, at all of the proteins coded at the genome.  It is   
   imaginable that just light exercise could up cytolocalized biochemicals and   
   circulating biochemicals 20%. During 2019 AD many people found it easy and   
   enjoyable to actually    
   double the mass of some of their muscles, so that might double the amount of a   
   preferred protein or circulating biochemical. Different genome product   
   directors and switches than exercise are likely to be more beneficial and   
   popular than exercise.     
   Drinking a gallon of water all at once, or getting a pleasurable massage once   
   every six months is much less effort to do, and sustain, as a goal-seeking   
   activity at consciousness than sustained exercise.   
      
   As a technology it is possible to do gene therapy on a just one body part, and   
   then have growth of that part make more of the phenotypic chemical like a   
   protein or other biochemical or chemical, to produce local effects (GFP output   
   changes with tissue    
   use which I think is published as increasing transcription at the utilized   
   tissue, exercising should therefore make GFP at muscle tissue increase, and   
   instead of GFP it could be different physiologically beneficial protein or   
   other biochemical)   
      
      
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    * Origin: you cannot sedate... all the things you hate (1:229/2)