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|    sci.chem    |    Chemistry and related sciences    |    55,615 messages    |
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|    Message 55,065 of 55,615    |
|    Treon Verdery to All    |
|    Rescue children:    |
|    06 Sep 22 00:45:45    |
      From: treon3verdery@gmail.com              the 100,000 mouse outdoor mouse dorm with one meter diameter circle of space       per mouse as well as computer processed and imterpreted video of behavior,       personalized to each mouse drug administration, stable isotope labelling of       numerous data areas at        mouse pellets mouse drug study protocol is use able to benefit human children:       100,000 pregnant mice can be dosed with a library of 2000-4000 new drugs and       drug variants that could reduce complications of pregnancy and birth defects;       if there are either        2 mouse birth defects per 100 birthed mouse litters or 2 birth defects per 100       birthed actual mice then the 100,000 pregnant mice at 7 mice per litter       produce between 2000 and 14,000 times a drug being screened can prevent a       birth defect; complications        during pregnancy are possibly near 1.6 per 100 during 2019 AD, so 100,000 mice       have a drug opportunity to prevent 1600 occurrences of complications during       pregnancy; online it says mice can have numerous litters annually, the most       being 14, so the        outdoor mouse dorm protocol, at a year round pleasant to mice climate could       have 11 litters annually to test birth defect reducing drugs and drugs that       reduce complications of pregnancy              Better than well babies; optimized developing baby also fetus epigenetics;       noting the outdoor mouse dorm can put mouse social behavior in a database and       link it to each mouse, at which drug, 100,000 epigenetic modifier molecules       can be screened as a        library on 100,000 pregnant mice, then the progeny's wellness, healthspan, and       longevity as well as social function and beneficial social fluency, cognitive       function and epigenetic phenomena like wellness restoring "clean slating" of       any preexisting non        beneficial epigenetic (chemical, food, social, possibly 7 year heritability       cycle (Sundet, heritability goes from .24 to .82 at 40k quantified Norwegians)       epigenetic effects is measured quantified and placed at a database from       screening a library of        epigenetic modifying molecules that have numerous new variants; the       HDACinhibitor 10HDA(10H2DA) makes mice live 25/27% longer in one study and       only makes below median mice live 15-17% longer in a different study, as a       molecule the mental wellness        fostering, nerve tissue healing, anxiolytic chemical HAEE is highly similar to       10 H2DA but is an ethyl ester, another (I think) HDAC2inhibitor is vornistat,       a molecule that looks kind of like long phenyl HAEE that causes greater       cognitive ability,        screening 10,000 variants of molecules at the shapes and atoms between HAEE,       10H2DA ,and vornistat could find epigenetic clean slate epigenetic wellness       restorers that have other benefits as well,               One thing that benefits babies, notably babies with stressed mothers, is       finding out if there are calming anxiolytic chemicals that cause better than       well effects and greater cognitive function 10,000 variations on rapamycin at       100,000 outdoor mouse dorm        mice could be quantified as to their effects on birth defects as well as               Are there harmless chemicals or drugs that cause better than well phenotype in       mammals at, optimally all pregnancies, noting though there could be beneficial       chemicals that cause 2-40 out of 100 dosed pregnancies to have a highly       beneficial        characteristic, a birth bonus, the opposite of a 1.5 per 100 birth defect rate       from a chemical; this brings up the qualitative idea of what is a birth bonus;       2-40 babies out of 100 having a 1 or 2 point higher apgar score, or a       measurable benefit at 7        year old, and 14 year old and 29 years as lifetime benefit of having maternal       BDNF levels at 140-200% higher than median, or possibly at the 99th percentile       of circulating maternal BDNF among women at 99th percentile of intelligence;       this could also be        tested at mice at say 40 levels of dosed maternal BDNF, and progeny's entire       longevity, wellness, healthspan, social function and fluency, mating success,       quantified              200 different amino acid sequence variants of brain derived neurotrophic       factor protein are made, each varying their lipiphilicity or hydrophilicity       from BDNF .5%, then these are administered to pregnant mice, young mice, and       mice of other ages, possibly        at an outdoor mouse dorm to find out if this causes notably beneficial tissue       or cyte localization compared with regular BDNF; a mixture of different BDNFs       could be made to optimize benefit              compare BDNF, various neurochemicals' genes between shrews, that weigh       possibly 2-3 grams and rats that weigh 140 grams while being cognitively       similar              Intelligence genes, some species like shrews and squirrels grow and shrink the       size of their brain depending on season, squirrels grow their              10HDA dose might be 15 mg/24 hours, vornistat dose might be 7/mg/24 hours; to       refill a 1600 chemical, 1600 autopipette pipettor with drugs and numerous Kg       of food goes with making the dinner station a big radio controlled car; some       quantity of these        drive out onto the mouse dorm field in shifts so there are always sufficient       dinner stations for the mice              --- SoupGate-Win32 v1.05        * Origin: you cannot sedate... all the things you hate (1:229/2)    |
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