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   sci.chem      Chemistry and related sciences      55,615 messages   

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   Message 55,065 of 55,615   
   Treon Verdery to All   
   Rescue children:   
   06 Sep 22 00:45:45   
   
   From: treon3verdery@gmail.com   
      
   the 100,000 mouse outdoor mouse dorm with one meter diameter circle of space   
   per mouse as well as computer processed and imterpreted video of behavior,   
   personalized to each mouse drug administration, stable isotope labelling of   
   numerous data areas at    
   mouse pellets mouse drug study protocol is use able to benefit human children:   
   100,000 pregnant mice can be dosed with a library of 2000-4000 new drugs and   
   drug variants that could reduce complications of pregnancy and birth defects;   
   if there are either    
   2 mouse birth defects per 100 birthed mouse litters or 2 birth defects per 100   
   birthed actual mice then the 100,000 pregnant mice at 7 mice per litter   
   produce between 2000 and 14,000 times a drug being screened can prevent a   
   birth defect; complications    
   during pregnancy are possibly near 1.6 per 100 during 2019 AD, so 100,000 mice   
   have a drug opportunity to prevent 1600 occurrences of complications during   
   pregnancy; online it says mice can have numerous litters annually, the most   
   being 14, so the    
   outdoor mouse dorm protocol, at a year round pleasant to mice climate could   
   have 11 litters annually to test birth defect reducing drugs and drugs that   
   reduce complications of pregnancy   
      
   Better than well babies; optimized developing baby also fetus epigenetics;   
   noting the outdoor mouse dorm can put mouse social behavior in a database and   
   link it to each mouse, at which drug, 100,000 epigenetic modifier molecules   
   can be screened as a    
   library on 100,000 pregnant mice, then the progeny's wellness, healthspan, and   
   longevity as well as social function and beneficial social fluency, cognitive   
   function and epigenetic phenomena like wellness restoring "clean slating" of   
   any preexisting non    
   beneficial epigenetic (chemical, food, social, possibly 7 year heritability   
   cycle (Sundet, heritability goes from .24 to .82 at 40k quantified Norwegians)   
   epigenetic effects is measured quantified and placed at a database from   
   screening a library of    
   epigenetic modifying molecules that have numerous new variants; the   
   HDACinhibitor 10HDA(10H2DA) makes mice live 25/27% longer in one study and   
   only makes below median mice live 15-17% longer in a different study, as a   
   molecule the mental wellness    
   fostering, nerve tissue healing, anxiolytic chemical HAEE is highly similar to   
   10 H2DA but is an ethyl ester, another (I think) HDAC2inhibitor is vornistat,   
   a molecule that looks kind of like long phenyl HAEE that causes greater   
   cognitive ability,    
   screening 10,000 variants of molecules at the shapes and atoms between HAEE,   
   10H2DA ,and vornistat could find epigenetic clean slate epigenetic wellness   
   restorers that have other benefits as well,    
      
   One thing that benefits babies, notably babies with stressed mothers, is   
   finding out if there are calming anxiolytic chemicals that cause better than   
   well effects and greater cognitive function 10,000 variations on rapamycin at   
   100,000 outdoor mouse dorm    
   mice could be quantified as to their effects on birth defects as well as    
      
   Are there harmless chemicals or drugs that cause better than well phenotype in   
   mammals at, optimally all pregnancies, noting though there could be beneficial   
   chemicals that cause 2-40 out of 100 dosed pregnancies to have a highly   
   beneficial    
   characteristic, a birth bonus, the opposite of a 1.5 per 100 birth defect rate   
   from a chemical; this brings up the qualitative idea of what is a birth bonus;   
   2-40 babies out of 100 having a 1 or 2 point higher apgar score, or a   
   measurable benefit at 7    
   year old, and 14 year old and 29 years as lifetime benefit of having maternal   
   BDNF levels at 140-200% higher than median, or possibly at the 99th percentile   
   of circulating maternal BDNF among women at 99th percentile of intelligence;   
   this could also be    
   tested at mice at say 40 levels of dosed maternal BDNF, and progeny's entire   
   longevity, wellness, healthspan, social function and fluency, mating success,   
   quantified   
      
   200 different amino acid sequence variants of brain derived neurotrophic   
   factor protein are made, each varying their lipiphilicity or hydrophilicity   
   from BDNF .5%, then these are administered to pregnant mice, young mice, and   
   mice of other ages, possibly    
   at an outdoor mouse dorm to find out if this causes notably beneficial tissue   
   or cyte localization compared with regular BDNF; a mixture of different BDNFs   
   could be made to optimize benefit   
      
   compare BDNF, various neurochemicals' genes between shrews, that weigh   
   possibly 2-3 grams and rats that weigh 140 grams while being cognitively   
   similar   
      
   Intelligence genes, some species like shrews and squirrels grow and shrink the   
   size of their brain depending on season, squirrels grow their   
      
   10HDA dose might be 15 mg/24 hours, vornistat dose might be 7/mg/24 hours; to   
   refill a 1600 chemical, 1600 autopipette pipettor with drugs and numerous Kg   
   of food goes with making the dinner station a big radio controlled car; some   
   quantity of these    
   drive out onto the mouse dorm field in shifts so there are always sufficient   
   dinner stations for the mice   
      
   --- SoupGate-Win32 v1.05   
    * Origin: you cannot sedate... all the things you hate (1:229/2)   

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