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|    Message 55,081 of 55,615    |
|    Treon Verdery to All    |
|    It is published that longevity goes up 2    |
|    06 Sep 22 05:43:18    |
      From: treon3verdery@gmail.com              New longevity drugs based on nootropics (smart drugs), Screen a million or       more nootropic molecule variants at yeast, c elegans; they may have longevity       molecule actions that complement their cognitive effects, then screen the       99.9th percentile of        longevizing nootropic sourced molecules on mice to find those that       simultaneously heighten longevity, subjective well being as well as cognitive       ability to make beneficial new human drugs              Phosphatidyl serine and variations as nootropics as well as quantifiable       longevity drug; other phosphatidyl amino acids and different molecule alkane       lengths could be screened as a library              Screen a library of a million nootropic molecule variants and find the       molecules that simultaneously heighten longevity, subjective well being like       happiness, and cognitive function, then test the 99.99 percentile of them on       mice, make them human drugs              All the greater than 100 neurotransmitter genes and all the brain morphology       genes could be characterized as to their effect on longevity, heightening       subjective well being and kindness as well as heightening cognitive ability;       the simultaneously        multibenefical effect chemicals, like proteins, the genes make are library       screened as protein drugs, those at the 99th or 99.9th percentile of multi       beneficial effect are then beneficial human drugs;               it is also possible that among the greater than 100 neurotransmitters there       are three where receptor activation is of greatest benefit as well as three       where receptor activity decrease causes benefit like greater longevity,       happiness as well as cognitive        ability, drugs that effect these nifty and antinifty neurotransmitter types       are then longevity, subjective well being, as well as cognitive ability       increasing drugs, and genetics of the nifty neurotransmitters are genetic       enhancement opportunities at        humans as well as are the antinifty neurotransmitters activity being        genetically reduced, which then heightens longevity or also happiness or also       cognitive ability at humans              Bile acids cause yeast to have doubled longevity and increase the maximum age       attained; screening a library of a million molecular variants on lithocholic       acid at yeast is a way to find new longevity drugs; Finding the 99.9 the       percentile of molecules        that heighten longevity at yeast then screening them at fish as well as mice,       then making human drugs creates new longevity drugs; among numerous molecules       variants screenable, along with combinatorial approaches, topology theme       variations (undulating        3dness at molecules, near planar molecules, rapidly or gradually repeatedly       changing shape (like chair boat at benzene), possibly there are variations at       hydrophobicity that happen to also be orders of magnitude differenct from each       other at        lipophilicity, dimerization at different sides of the molecule, protein       versions, that to my perception can actually imitate few AMU drugs, making the       distal thing that looks like a butyl to be propyl, heptyl, 6,7,8,9,10 C long       (notably longevity        molecule 10HDA(10H2DA) could be the distal thing), making the cyclohexane like       parts of the molecule unsaturated (C=C areas, like partial benzenes) as well       as making them cycloheptyl (7 atom circle) vesions at some of them, removing       or replacing the        methyl branch with an ethyl, propyl or other lipophilic alkane, changing the       =O at the ester to a sulfur, as well as replacing the carboxyl with an amide       (less hydrophilic), screen able variants like fluorine or other halogen where       the hydrogen's are (       fluorine might be notably hydrophobic from the teflonization I perceive       possible, also some fluorinated drugs have 1000 times greater activity per mg,       enhancing pills/dosing as well as heightening affordability possibly 1000       times, also ethynylization,        noting lithocholic acid is cholesterolish and that ethynylizing cholesterolish       sex hormones like progesterone makes them hundreds of times more active and       active at a few hundred picograms per human dose; noting that sex hormones       are cholesterolish,        lithocholic acid variations with similarity to the published longevity drug,       nonfeminizing 17 alpha estradiol which causes 11% greater longevity could be       among the screenable variants              Complementing screening a library of lithocholic acid variants, making       radiolabelled versions and at the 14 most longevizing variants out of a       million find out which cytoareas, receptors, as well as genetics the 99.999th       percentile of heightening        longevity variants effect               three or fouteen genes producing differing bile acid molecules linkable to       human longevity could be longevity genes                                          Nootropic stimulants              --- SoupGate-Win32 v1.05        * Origin: you cannot sedate... all the things you hate (1:229/2)    |
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