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   sci.chem      Chemistry and related sciences      55,615 messages   

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   Message 55,081 of 55,615   
   Treon Verdery to All   
   It is published that longevity goes up 2   
   06 Sep 22 05:43:18   
   
   From: treon3verdery@gmail.com   
      
   New longevity drugs based on nootropics (smart drugs), Screen a million or   
   more nootropic molecule variants at yeast, c elegans; they may have longevity   
   molecule actions that complement their cognitive effects, then screen the   
   99.9th percentile of    
   longevizing nootropic sourced molecules on mice to find those that   
   simultaneously heighten longevity, subjective well being as well as cognitive   
   ability to make beneficial new human drugs   
      
   Phosphatidyl serine and variations as nootropics as well as quantifiable   
   longevity drug; other phosphatidyl amino acids and different molecule alkane   
   lengths could be screened as a library   
      
   Screen a library of a million nootropic molecule variants and find the   
   molecules that simultaneously heighten longevity, subjective well being like   
   happiness, and cognitive function, then test the 99.99 percentile of them on   
   mice, make them human drugs   
      
   All the greater than 100 neurotransmitter genes and all the brain morphology   
   genes could be characterized as to their effect on longevity, heightening   
   subjective well being and kindness as well as heightening cognitive ability;   
   the simultaneously    
   multibenefical effect chemicals, like proteins, the genes make are library   
   screened as protein drugs, those at the 99th or 99.9th percentile of multi   
   beneficial effect are then beneficial human drugs;    
      
   it is also possible that among the greater than 100 neurotransmitters there   
   are three where receptor activation is of greatest benefit as well as three   
   where receptor activity decrease causes benefit like greater longevity,   
   happiness as well as cognitive    
   ability, drugs that effect these nifty and antinifty neurotransmitter types   
   are then longevity, subjective well being, as well as cognitive ability   
   increasing drugs, and genetics of the nifty neurotransmitters are genetic   
   enhancement opportunities at    
   humans as well as are the antinifty neurotransmitters activity being    
   genetically reduced, which then heightens longevity or also happiness or also   
   cognitive ability at humans   
      
   Bile acids cause yeast to have doubled longevity and increase the maximum age   
   attained; screening a library of a million molecular variants on lithocholic   
   acid at yeast is a way to find new longevity drugs; Finding the 99.9 the   
   percentile of molecules    
   that heighten longevity at yeast then screening them at fish as well as mice,   
   then making human drugs creates new longevity drugs; among numerous molecules   
   variants screenable, along with combinatorial approaches, topology theme   
   variations (undulating    
   3dness at molecules, near planar molecules, rapidly or gradually repeatedly   
   changing shape (like chair boat at benzene), possibly there are variations at   
   hydrophobicity that happen to also be orders of magnitude differenct from each   
   other at    
   lipophilicity, dimerization at different sides of the molecule, protein   
   versions, that to my perception can actually imitate few AMU drugs, making the   
   distal thing that looks like a butyl to be propyl, heptyl, 6,7,8,9,10 C long   
   (notably longevity    
   molecule 10HDA(10H2DA) could be the distal thing), making the cyclohexane like   
   parts of the molecule unsaturated (C=C areas, like partial benzenes) as well   
   as making them cycloheptyl (7 atom circle) vesions at some of them, removing   
   or replacing the    
   methyl branch with an ethyl, propyl or other lipophilic alkane, changing the   
   =O at the ester to a sulfur, as well as replacing the carboxyl with an amide   
   (less hydrophilic), screen able variants like fluorine or other halogen where   
   the hydrogen's are (   
   fluorine might be notably hydrophobic from the teflonization I perceive   
   possible, also some fluorinated drugs have 1000 times greater activity per mg,   
   enhancing pills/dosing as well as heightening affordability possibly 1000   
   times, also ethynylization,    
   noting lithocholic acid is cholesterolish and that ethynylizing cholesterolish   
   sex hormones like progesterone makes them  hundreds of times more active and   
   active at a few hundred picograms per human dose;  noting that sex hormones   
   are cholesterolish,    
   lithocholic acid variations with similarity to the published longevity drug,   
   nonfeminizing 17 alpha estradiol which causes 11% greater longevity could be   
   among the screenable variants   
      
   Complementing screening a library of lithocholic acid variants, making   
   radiolabelled versions and at the 14 most longevizing variants out of a   
   million find out which cytoareas, receptors, as well as genetics the 99.999th   
   percentile of heightening    
   longevity variants effect   
      
    three or fouteen genes producing differing bile acid molecules linkable to   
   human longevity could be longevity genes   
      
      
      
      
      
   Nootropic stimulants   
      
   --- SoupGate-Win32 v1.05   
    * Origin: you cannot sedate... all the things you hate (1:229/2)   

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