From: treon3verdery@gmail.com   
      
   Medicines that are effective and highly affordable benefit children, globally   
   and at the developing world;   
   I think peptide drugs are often dosable at near 100 micrograms to 1 milligram   
   each, a million milligrams at $1000 is 1/1000 of 1 cent a miiligram dose, it   
   is 1/100th of a cent, at 100 micrograms per dose it is 1/10,000 of 1 cent   
   ($1000 Kg) , 100    
   micrograms at $10,000 a Kg is 1/1000 of 1 cent, screening the database of   
   about 40 million (2019)   
   Pubmed/PMC articles to find the 300 peptides most likely to succeed as drugs   
   comes from parsing the data   
      
   One approach to parsing the data is a computer program, a database, or an AI,   
   possibly a deep learning AI   
      
   Find peptide name   
   Find math 40 reporting types   
   Rank math number reports   
      
   Finding peptides previously used as drugs:   
   Alternate version, crowdsourced human screening of 10,000 to 100,000 most   
   likely pub med PMC records the computer finds   
   Automated software finds patient studies and nonhuman mammal srudies   
   40 words like "response", " administer",    
   Research source: medical center   
   Find patient words   
   Stand alone sentence like "antibiotic peptide reduces days of unwellness"   
      
      
   Screen again as complementary therapy, " fluorcorticoid adminstered with GABA   
   peptide"even though drug drug interactions    
      
      
   find the simultaneous occurrence of the worlds 100 most common diseases and   
   also the statistical math expressions of high.  effectiveness at at pcausing   
   any change at the hypothesis,    
      
   at jnoting that Pubmed/PMC says it indexes about 40 million papers during 2019   
   AD, parsing the data to gather peptide name, amount of  from automatic   
   parsing, and having the software find the peptides with the highest p value   
   are simultaneously published    
   as having possible medical application  among all medically active peptides,   
   and  software that parses  of the active peptides, or, variously listing the   
   three most likely to be medically useful at the 100 most frequently occurring   
   illnesses is another    
   way to generate a list of 300 medical drug peptides;   
      
   The list of the 300 most immediately utilizable peptide drugs could be   
   refashion as medicines; oral vasopressin utilizes a combination of chiral   
   amino acids to omit digestion from GI tract enzymes, it is possible peptide   
   sequencers and comparatively    
   uncomplex software that generates 10 million variations in software then makes   
   a list of 1 million that the least projected enzymatic digestion at the GI   
   tract, then a peptide sequencer attached to a million channel microfluidic   
   chip I read about could    
   move the million peptides have enzymatic digestion blocking chirality exposed   
   lysine amino acids; I do not know how meaningful enzymatic lysine cleavage is   
   but I think I read it is a frequent enzymatic cleaveage site; people that know   
   whether it is    
   better to make 500,000 peptide variants of GI tract enzyme and pH undigested,   
   structurally projected at software as passing membranes and reaching the   
   circulation, peptides then screening them on yeast or human tissue culture at   
   a one million well plate    
   is more sensible than having 11 technologists use software and CAD to just   
   draw the structures they think will pass the GI tract, notably the orally   
   dosed vasopressin peptide  that passes the GI tract to be absorbed, based   
   partly on having two    
   chiralities of amino acids rather than just the one chirality that the   
   digestive tract enzymes cleave (digest) peptides with,  then the technologists   
   could use CAD and a programming language to automatically replace some of the   
   peptides at the structure    
   library with chirally unusual nucleotides, then automatically modify the   
   structure library to put something like an intestinal membrane transport   
   peptide, possibly cleabeable at the circulatory system with a circulatory   
   system circulating enzyme that    
   cleaves away the transport nucleotide sequence; i think i read that at least   
   one enzyme cleaves peptides on the amino lysine, the technologist might use   
   CAD to swap lysine with another. Most similar amino acid to preprocess the 300   
   medical peptides    
   before the 11 technologists customize the CAD specifications of the 300   
   medical peptides, perhaps making 20 version variations for a higher   
   functionality screenable library of 6000 peptides, there is a possibility (?)   
   That the 6000 medical peptides could    
   then be transported through a microfluidic reactor with sequential digestive   
   enzymes and pH areas to find out which peptide versions of the 300 medical   
   peptides among 6000 will reach the circulation with fulldrug function; the   
   peptides that pass the    
   microfluidic reactor can then be automatically transported to a 10,000 well   
   plate yeast culture matrix or also human tissue culture to find each version   
   of the 300 medical peptides   
      
   If the parallism of the microfluidic enzyme system and the quantification of   
   drug activity at the 10,000 well plate supports it then greater than 300   
   medical peptides can be made to become orally available drugs;   
      
   --- SoupGate-Win32 v1.05   
    * Origin: you cannot sedate... all the things you hate (1:229/2)