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   sci.chem      Chemistry and related sciences      55,615 messages   

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   Message 55,156 of 55,615   
   Treon Verdery to All   
   A pill that lasts a month or longer is b   
   07 Sep 22 19:48:24   
   
   From: treon3verdery@gmail.com   
      
   Noting that a drug carrying microsome or liposome could have three layers, one   
   of them surgical glue, a pill that has as outer layer that only dissolves when   
   the microsome or liposome is at direct contact with a GI tract membrane, then   
   enzymatically    
   degraded right at the membrane surface that exterior layer dissolves exposing   
   the surgical glue layer, the surgical glue then glues the drug diffusing core   
   to the membrane and the glued-on drug diffuses to the system as long as the   
   surgical glue holds,    
   palmitate drugs like fluoxetine palmitate last 7 days on ingestion so if the   
   surgical glue lasts a month then 37 day oral pill is produced, at the brush   
   cytes of the GI tract membrane an acetylase is produced that divides sucrose   
   at the acetyl to make    
   glucose and fructose, an acetylated polymer that disintegrates at the   
   membrane, when next to brush cytes could be produced, one particularly   
   affordable possibility is a sucrose polymer   
      
   An oral pill that lasts a year, at a three layer pill, an endocytosis moiety   
   or protein that effects vascular epithelia to do endocytosis, at a location   
   physically just after the membrane, is attached to the drug, the vascular   
   cytes uptake the drug then    
   it gradually diffuses out of their cytoplasm into the circulatory system, at a   
   better version it is possible that enzymatically degradable ensconcement   
   proteins of 1-14 different thickness layers are around the actual drug that   
   endocytosis has brought to    
   the cytoplasm of the vascular cytes, between each of the 14 layers of   
   ensconscement protein is some active drug, and so as cytoplasmic enzymes   
   gradually wear away the layers of the ensconcement protein 14 gradually   
   diffusing doses are activated, the    
   actual drug molecule could have an efflux transport channel moiety or peptide   
   on it so the vascular cyte would actively place the drug at the circulatory   
   system, drugs that are active at microgram or nanogram quantities per 24 hours   
   support this, peptide    
   drugs, protein drugs, antigens where repeated multiday exposure builds greater   
   immunoresponse (say to malaria or mTOR receptors), as well as ethynyl   
   fluorinated drugs with cytomembrane transport channel moieties on them (1000   
   times activity from    
   halogenation, 1000 ethynylization, 1000 cytotransport moiety) these drugs can   
   be potent at a millionth the starting drug molecule's dose, a 700 nanogram/24   
   hour dose is just 256 micrograms of drug at the oral pill, a 300 microgram a   
   day dose is just 1.1    
   mg of drug at the pill, a once a year oral contraceptive would be beneficial   
   and has less than 1mg of active pharmaceutical ingredient   
      
   A longevity drug pill you take once a year, or once every few centuries is   
   beneficial   
      
   People thought about to be other than alive could get gene therapy that   
   provides benefit across the full range of things they think could happen if a   
   person ceases to be alive, from making people nicer and more intelligent, to   
   having the genetics of    
   people who are absent any aversive sensation to any aversive stimulus,   
   including asphyxia, to having the genetics of the mentally well, Tolerance of   
   crowding, as well as the genetics of being calm, as an effective gene therapy   
   this could be oral gene    
   therapy or injected, and it is also beneficial to inject in the bodies of the   
   previously alive   
      
   --- SoupGate-Win32 v1.05   
    * Origin: you cannot sedate... all the things you hate (1:229/2)   

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