Forums before death by AOL, social media and spammers... "We can't have nice things"
|    sci.chem    |    Chemistry and related sciences    |    55,615 messages    |
[   << oldest   |   < older   |   list   |   newer >   |   newest >>   ]
|    Message 55,156 of 55,615    |
|    Treon Verdery to All    |
|    A pill that lasts a month or longer is b    |
|    07 Sep 22 19:48:24    |
      From: treon3verdery@gmail.com              Noting that a drug carrying microsome or liposome could have three layers, one       of them surgical glue, a pill that has as outer layer that only dissolves when       the microsome or liposome is at direct contact with a GI tract membrane, then       enzymatically        degraded right at the membrane surface that exterior layer dissolves exposing       the surgical glue layer, the surgical glue then glues the drug diffusing core       to the membrane and the glued-on drug diffuses to the system as long as the       surgical glue holds,        palmitate drugs like fluoxetine palmitate last 7 days on ingestion so if the       surgical glue lasts a month then 37 day oral pill is produced, at the brush       cytes of the GI tract membrane an acetylase is produced that divides sucrose       at the acetyl to make        glucose and fructose, an acetylated polymer that disintegrates at the       membrane, when next to brush cytes could be produced, one particularly       affordable possibility is a sucrose polymer              An oral pill that lasts a year, at a three layer pill, an endocytosis moiety       or protein that effects vascular epithelia to do endocytosis, at a location       physically just after the membrane, is attached to the drug, the vascular       cytes uptake the drug then        it gradually diffuses out of their cytoplasm into the circulatory system, at a       better version it is possible that enzymatically degradable ensconcement       proteins of 1-14 different thickness layers are around the actual drug that       endocytosis has brought to        the cytoplasm of the vascular cytes, between each of the 14 layers of       ensconscement protein is some active drug, and so as cytoplasmic enzymes       gradually wear away the layers of the ensconcement protein 14 gradually       diffusing doses are activated, the        actual drug molecule could have an efflux transport channel moiety or peptide       on it so the vascular cyte would actively place the drug at the circulatory       system, drugs that are active at microgram or nanogram quantities per 24 hours       support this, peptide        drugs, protein drugs, antigens where repeated multiday exposure builds greater       immunoresponse (say to malaria or mTOR receptors), as well as ethynyl       fluorinated drugs with cytomembrane transport channel moieties on them (1000       times activity from        halogenation, 1000 ethynylization, 1000 cytotransport moiety) these drugs can       be potent at a millionth the starting drug molecule's dose, a 700 nanogram/24       hour dose is just 256 micrograms of drug at the oral pill, a 300 microgram a       day dose is just 1.1        mg of drug at the pill, a once a year oral contraceptive would be beneficial       and has less than 1mg of active pharmaceutical ingredient              A longevity drug pill you take once a year, or once every few centuries is       beneficial              People thought about to be other than alive could get gene therapy that       provides benefit across the full range of things they think could happen if a       person ceases to be alive, from making people nicer and more intelligent, to       having the genetics of        people who are absent any aversive sensation to any aversive stimulus,       including asphyxia, to having the genetics of the mentally well, Tolerance of       crowding, as well as the genetics of being calm, as an effective gene therapy       this could be oral gene        therapy or injected, and it is also beneficial to inject in the bodies of the       previously alive              --- SoupGate-Win32 v1.05        * Origin: you cannot sedate... all the things you hate (1:229/2)    |
[   << oldest   |   < older   |   list   |   newer >   |   newest >>   ]
(c) 1994, bbs@darkrealms.ca