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|    Message 55,160 of 55,615    |
|    Treon Verdery to All    |
|    Things that fill children with happiness    |
|    07 Sep 22 19:56:11    |
      From: treon3verdery@gmail.com              CPU speakers or social companion robots could notice when adults and siblings       were at 90th percentile of previously measured happiness and suggest that       children interact with people like their oarents or siblings then. Timing       could contribute to child        snd adult hapoiness, so CPU speakers that amplify adult and sibling happiness       could amplify child happiness.              Longevity technology       Sleep causes greater healthspan, wellness, and optmal amounts of sleep may       have longevity increasing effects as well, they could find out what 1000 or       100 chemicals most increase from several hours of sleep, are newly produced,       or are decreased from        optimal sleep and find out if supplementing mice or c elegans with those       chemicals increases lifespan, circulating chemicals as well as tissue specific       chemicals like brain, cardiovascular system, liver and heart could be       utilized, chemicals from tissue        homogenates from optimally sleeping and awake primate monozygotic twins or       other 8 hour sleeping mammals (cows? Horses? Pigs?) could be used              Do BDNF, NGF as well as other nerve growth factors have beneficial longevity       effects or healthspan effects at non neural tissues, this could be tested at       human tissue culture, age batched very elderly persons, and a BDNF version       with a polyglycine,        protein or other peptide attached to the BDNF or other nerve growth factor so       the nerve growth factor does not pass the blood brain barrier (stable isotope       verified), this could be tested at mice to find out if the nerve growth       factors increase longevity,        if they also increase longevity at yeast or c elegans a million molecular       variants could be tested at yeast or 10k versions tested at c elegans (107 or       a few hundred 96 well plates) to find a version with greater longevity       increase, are there peptide        nrtbe growth factors? Also, if nerve growth factors cause greater longevity       this could be a gene therapy longevity or healthspan technology and could also       be made part of the human germline              Marmosets are a primate that could be batched into 6 months, one year, two       years, and four year prior to being previously alive groups and used to test       longevity drugs and the effect of longevity drugs on progeny,               Divergence of physiochistry from that of humans approaching being previously       alive: from age 11, circulatory system fluids and cheek swabs tissue samples       could be used to characterized to show the gradual or sudden changes of people       as they traverse the        years from 11 to being previously alive, eight samples from each year of age       are sufficient to get a p value, so from 11 to supercentenarians is not that       many samples, the chemicals that gradually change, those that increase or       decrease are then tested        on c elegans and yeast to find those that lonhevize yeast or, at cumulative or       sudden human physiological chemical change otherwise modulate c elegans and       yeast longevity and wellness or healthspan, chemicals at the 97th percentile       above at causing a        change in any direction could be tested on mice,immunizations against       deleterious chemicals could cause greater longevity as well as healthspan, and       supplementing with beneficial chemicals could cause greater longevity and       healthspan. Some of the        physiochemicals may be symptomatic, others might be causative like the       deleterious interleukin senolytics get rid of, a really rapid version of this       study would use 9 circulatory system circulating fluids and actual tissue       samples from rats or cows, pigs,        or horses, identify and measure the physiochemicals, administer them to yeast       then test the 97the percentile of physiochemicals that cause the greatest       change on mice, if large animals are used (horses, cows, pigs) then the large       animal plasma or        tissues can be used as a plentiful source of test chemicals for the mice,       another approach is just to get 7 discrete human year of age equivalent       samples from large mammals, mass sort, or electrophoretically sort that into       700 different testable plasma        fraction materials then test those 4900 different plasma fractions on c       elegans (53 or hundreds of plates) and yeast to find out if pjysiochemicals       from chemical change progression with age shows beneficial or deleterious       chemicals, if there is an effect        then that electrophoretic or mass sorted plasma fraction could be       electrophoresis sized or mass sorted further and partitioned into another 900       groups to find the longevity and wellness chemicals with greater precision              --- SoupGate-Win32 v1.05        * Origin: you cannot sedate... all the things you hate (1:229/2)    |
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