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   sci.chem      Chemistry and related sciences      55,615 messages   

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   Message 55,160 of 55,615   
   Treon Verdery to All   
   Things that fill children with happiness   
   07 Sep 22 19:56:11   
   
   From: treon3verdery@gmail.com   
      
   CPU speakers or social companion robots could notice when adults and siblings   
   were at 90th percentile of previously measured happiness and suggest that   
   children interact with people like their oarents or siblings then. Timing   
   could contribute to child    
   snd adult hapoiness, so CPU speakers that amplify adult and sibling happiness   
   could amplify child happiness.   
      
   Longevity technology   
   Sleep causes greater healthspan, wellness, and optmal amounts of sleep may   
   have longevity  increasing effects as well, they could find out what 1000 or   
   100 chemicals most increase from several hours of sleep, are newly produced,   
   or are decreased from    
   optimal sleep and find out if supplementing mice or c elegans with those   
   chemicals increases lifespan, circulating chemicals as well as tissue specific   
   chemicals like brain, cardiovascular system, liver and heart could be   
   utilized, chemicals from tissue    
   homogenates from optimally  sleeping and awake primate monozygotic twins or   
   other 8 hour sleeping mammals (cows? Horses? Pigs?) could be used   
      
   Do BDNF, NGF as well as other nerve growth factors have beneficial longevity   
   effects or healthspan effects at non neural tissues, this could be tested at   
   human tissue culture, age batched very elderly persons, and a BDNF version   
   with a polyglycine,    
   protein or other peptide attached to the BDNF or other nerve growth factor so   
   the nerve growth factor does not pass the blood brain barrier (stable isotope   
   verified), this could be tested at mice to find out if the nerve growth   
   factors increase longevity,   
    if they also increase longevity at yeast or c elegans a million molecular   
   variants could be tested at yeast or 10k versions tested at c elegans (107 or   
   a few hundred 96 well plates) to find a version with greater longevity   
   increase, are there peptide    
   nrtbe growth factors? Also, if nerve growth factors cause greater longevity   
   this could be a gene therapy longevity or healthspan technology and could also   
   be made part of the human germline   
      
   Marmosets are a primate that could be batched into 6 months, one year, two   
   years, and four year prior to being previously alive groups and used to test   
   longevity drugs and the effect of longevity drugs on progeny,    
      
   Divergence of physiochistry from that of humans approaching being previously   
   alive: from age 11, circulatory system fluids and cheek swabs tissue samples   
   could be used to characterized to show the gradual or sudden changes of people   
   as they traverse the    
   years from 11 to being previously alive, eight samples from each year of age   
   are sufficient to get a p value, so from 11 to supercentenarians is not that   
   many samples, the chemicals that gradually change, those that increase or   
   decrease are then tested    
   on c elegans and yeast to find those that lonhevize yeast or, at cumulative or   
   sudden human physiological chemical change otherwise modulate c elegans and   
   yeast longevity and wellness or healthspan, chemicals at the 97th percentile   
   above at causing a    
   change in any direction could be tested on mice,immunizations against   
   deleterious chemicals could cause greater longevity as well as healthspan, and   
   supplementing with beneficial chemicals could cause greater longevity and   
   healthspan.  Some of the    
   physiochemicals may be symptomatic, others might be causative like the   
   deleterious interleukin senolytics get rid of, a really rapid version of this   
   study would use 9 circulatory system circulating fluids and actual tissue   
   samples from rats or cows, pigs,   
    or horses, identify and measure the physiochemicals, administer them to yeast   
   then test the 97the percentile of physiochemicals that cause the greatest   
   change on mice, if large animals are used (horses, cows, pigs) then the large   
   animal plasma or    
   tissues can be used as a plentiful source of test chemicals for the mice,   
   another approach is just to get 7 discrete human year of age equivalent   
   samples from large mammals, mass sort, or electrophoretically sort that into   
   700 different testable plasma    
   fraction materials then test those 4900 different plasma fractions on c   
   elegans (53 or hundreds of plates) and yeast to find out if pjysiochemicals   
   from chemical change progression with age shows beneficial or deleterious   
   chemicals, if there is an effect    
   then that electrophoretic or mass sorted plasma fraction could be   
   electrophoresis sized or mass sorted further and  partitioned into another 900   
   groups to find the longevity and wellness chemicals with greater precision   
      
   --- SoupGate-Win32 v1.05   
    * Origin: you cannot sedate... all the things you hate (1:229/2)   

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