From: treon3verdery@gmail.com   
      
   Magnesium threonate is nootropic that makes rodents about 124% better at   
   refinding hidden objects, but, to my perception is only mildly nootropic at   
   humans, they could do gene and receptor studies it is possible acetyl   
   magnesium threonate would pass the    
   blood brain barrier even more effectively, they could test this on mice and   
   primates, if harmless humans could try it, another approach is an active   
   cytomembrane transport moiety these might make it stronger at humans   
      
   I favor people using nootropics, my experience is that if it only heightens   
   cognition without a fun factor taking them often does not occur to me, a mild   
   fun factor could cause people to use more nootropics, localization at the   
   nucleus accumbens or    
   perhaps mild rapid dopamine stimulation might do it   
      
   Phenibut has some nootropic effects even though it is a GABA activator, they   
   could make a plurality of molecular variations and test them on rats, that I   
   read have more cognitive ability than mice, to find a highly nootropic   
   version, also there are GABA    
   active peptides   
      
   I seem to remember something about peptides that have a reverse order still   
   functioning, it could be that I am thinking about RNA though, possibly at DNA   
   or, if RNA has it, reversing the 3' and 5' polarity might block transcription   
   or make the ribosomes    
   make some novel thing, if it blocks transcription then nucleic acid drugs or   
   gene therapy could make reverse RNA or DNA and cause deleterious things to be   
   produced less, I do not know if enteric coated nucleic acid drugs make it past   
   GI tract membranes,    
   but noting peptides do, it is likely it is functional, active transport   
   proteins, peptides, or moieties, including nuclear membrane transport peptides   
   could get them to where they have greater effect, although reverse RNA is, to   
   my perception, functional    
   at the cytoplasm   
      
   Does the endoplasmic reticulum have active transport, if it does there could   
   be new endoplasmic reticulum drugs   
      
   NR and NMN have names kind of like nicotinamide riboside, they could screen a   
   bunch of, and I think this is possible, other sugars than ribose at the   
   molecule to find out if any of them have even larger benefits, the   
   combinatorial space of where all the -   
   H and -OH on ribose are might be large so they could screen them on yeast and   
   c elegans, then on mice   
      
   Some drugs like LSD and "foxy" 5 meo-tryptophan cause durable increase in   
   function, they could figure out what causes that, like if just part of an LSD   
   molecule or just part of a 5-meo tryptophan molecule is attached to MDMA or a   
   nootropic is there a    
   chance some milder version of the effect could be durable   
      
   There could be a genetic basis to greater creativity at some people when going   
   to sleep, showering, or drowsing at awakening, those could be beneficial   
   creativity genes, they could find people who report at 95th pertcentile the   
   amount of drowsy    
   creativity they have then find out if there are shared genes, particularly at   
   monozygotic twins    
      
   New nootropics, it could be that any AMPA receptor drug (the racetams, like   
   phenylpiracetam) with any kind of brain localization, have different effects   
   from each other, there are immunohistology maps of the brain, perhaps a really   
   weak, floppy,    
   automatically detaching imitation antibody could do some brain structure   
   localization   
      
   Centrophenoxine has a chlorophenoxy group on it, it is possible BrPhenoxy or   
   fluorophenoxy, or IPhenoxy have different localization   
      
   I suppose I should think about what makes an effective beneficial nootropic,   
   more moments of noticing yet with higher focus, quantifiable increases in g   
   (like IQ), no effect or beneficial effect on emotions, permits easy sleep, and   
   lasts 8-14 hours, some    
   things like greater access to previously learned material would be beneficial.   
   As well as a mild fun factor   
      
   I read sucrose solution improves brain performance, then I also think I read   
   some other researchers found no effect, they could try a variety of other   
   sugars and see if any of them are better, then halogenate or acetylate them.   
   They could see what is    
   functional on rats, and if harmless then on humans   
      
   --- SoupGate-Win32 v1.05   
    * Origin: you cannot sedate... all the things you hate (1:229/2)