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|    sci.chem    |    Chemistry and related sciences    |    55,615 messages    |
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|    Message 55,190 of 55,615    |
|    Treon Verdery to All    |
|    Sperm preservation and lyophilization te    |
|    08 Sep 22 07:16:25    |
      From: treon3verdery@gmail.com              At sperm bank sperm it would be highly beneficial to know the genetic contents       of a single sperm before it was used for fertilization, and to be able to sort       a diluted ejacualte into separate fractions each with different desiable       genetics so that the        sperm bank client can choose to get the largest number of her criteria       (longevity, intelligence, beauty, others) simultaneously; DNA is all coiled up       at a sperm,               Density gradient sperm sorting or flow cytometry sperm sorting is described at       wikipedia as being 90% effective at producing all female sperm; Another       technology that might do this could be called narrow egg carton sperm sorting;       I perceive female        chromosome bearing sperm are physically slightly larger than Y containing       sperm; A two layer laminated thing, with one layer being a gel polymer with       fallopian tube and egg scent/flavor added to it, then with a depthy filter,       similar to an egg carton        placed on top of it is able to allow only those sperm that fit through the egg       carton holes to reach the flavor layer; the flavor layer also has a sperm       terminating chemical like nonoxynol 9 (or something better), so, larger sperm       while attarcted to the        egg carton laminate cannot fit through the holes and bounce off of it, to       continue seeking an opportunity to fertilize; noting that female sperm are       larger, if it is experimentally verified they are fertile and normal, the       99.99th percentile of largest        sized sperm are likely to be disproportionately female, optimally 99%+ female,       so with a plurality of very minute duopolymer egg carton Y chromosome sperm       terminating assemblies, of perhaps 60-100 microns deep (from holes to scented       poison) and at least        100 microns width and breadth, I am reminded of approximately 1x1mm pieces of       edible glitter in various products; that is about 100 sperm terminating       assemblies per mm^2, so 100,000 pieces of glitter in a sexual lubricant that       sex selects to favor the        conception of female babies would sequester and terminate 10 million sperm; as       a typical ejaculate is near 60 million sperm it is better to have a system       that can terminate up to 200 million sperm; one possibility is a poison and       scent core, externally        egg-crated entrance screen cellulose fibers that are embossed (made) while       dry, then become viscid, slippery, and pleasant at a sexual lubricant when       introduced into the vagina (some cellulose forms are gooey); The number of       ingress and terminate        pathway egg crates, each of which terminates 1 sperm, there could be at a 10%       cellulose fiber solution, is likely to be a whole bunch, possibly more than       several hundred million; an entire 14 grams (1/2 oz) of sexual lubricant might       have a really really        large amount of sperm terminating assemblies. Notably the 99.99 or 99.999th       percentile of sperm largeness keeps them out of the egg crate assemblies and       they can swim to reach the egg and fertilize it              A highly similar system can be produced that lasts all month, or several       months, and is possibly 1-2 cents made from alibaba.com parts; A cervical cap       is a polymer cup that fits over the cervix tightly enough to keep out all       sperm, and can be worn all        month, being taken out only for mestruation. Placing sorted sperm or also       genetically enhanced sperm, or also genetically optimized sperm in a cervical       cup and wearing it assures that sperm seeking the fallopian tubes and eggs       will ne near the cervix        and continuously available many days before ovulation, during ovulation and       after ovulation, increasing the likeliness of getting pregnant; the 1 month or       longer durability of the sperm is suggested by a published thing that I think       actually said that at        microencapsulated live sperm they had 100% viability after 30 days (but were       cooled 15C), that suggests that even if 5% of the sperm survive a month at       body temperature in the microcapsule, getting pregnant all month is possible;       The emphasis here is        convenience and getting to skip keeping track of calenders, you just pop it in       and it works. That is also particularly beneficial for people getting sperm       bank sperm; the sperm arrives in a cervical cap, you let the cervical cap thaw       for 40 minutes, pop        it in and you have done your part to get pregnant for the month, additionally       as a cervical cap is contraceptive to sperm outside of of it, you can have sex       with your exisitng partners and lovers as usual and still get pregnant with       the sperm bank sperm;        another benefit from having the sperm right next to the cervical canal is that       it likely takes just a few well positioned microliters to cause a pregnancy,       making particularly gifted donors able to donate to thousands (2Ml = 2000       microliters)              A technology that increases the number of sperm that make it up the cervix       toget nearer the egg is using a proteolytic (protein dissolving) enzyme that       only effects mucoproteins like those found in cervical mucous, as part of the       technology these        proteolytic enzymes do not have an effect on the sperm, It may be that full       mucolysis (all the mucous gone) is less than say 80% of the mucous dissolved              A further technology that could assist the sperm in reaching the egg is making       the sperm’s chemoreception (smelling ability) better; antibodies, tail       proteins, two sample chemoreceptors              It might be possible               At sperm bank sperm it would be highly beneficial to know the genetic contents       of a single sperm before it was used for fertilization, and to be able to sort       a diluted ejacualte into separate fractions each with different desiable       genetics so that the        sperm bank client can choose to get the largest number of her criteria       (longevity, intelligence, beauty, others) simultaneously; DNA is all coiled up       at a sperm,               Three systems that could actually look at the genes in the sperm while       maintain sperm fertility and motility are 1) quantum camera 2) something a       little like a deuterated primer (1/2 DNA ladder) attached to a quantum dot 3)       A nestling custom protein with        an IR spectroscopy spectrum, 4) has anybody tried laser tweezers that shine       through a sperm to move around the things inside the sperm                     Identicality, then dissasemble sample, might work, maybe sperm are clonal, if       you have 32 identicals and know it you can gene sequence on and extrapolate to       the remaining 31              --- SoupGate-Win32 v1.05        * Origin: you cannot sedate... all the things you hate (1:229/2)    |
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