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   sci.chem      Chemistry and related sciences      55,615 messages   

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   Message 55,190 of 55,615   
   Treon Verdery to All   
   Sperm preservation and lyophilization te   
   08 Sep 22 07:16:25   
   
   From: treon3verdery@gmail.com   
      
   At sperm bank sperm it would be highly beneficial to know the genetic contents   
   of a single sperm before it was used for fertilization, and to be able to sort   
   a diluted ejacualte into separate fractions each with different desiable   
   genetics so that the    
   sperm bank client can choose to get the largest number of her criteria   
   (longevity, intelligence, beauty, others) simultaneously; DNA is all coiled up   
   at a sperm,    
      
   Density gradient sperm sorting or flow cytometry sperm sorting is described at   
   wikipedia as being 90% effective at producing all female sperm; Another   
   technology that might do this could be called narrow egg carton sperm sorting;   
   I perceive female    
   chromosome bearing sperm are physically slightly larger than Y containing   
   sperm;  A two layer laminated thing, with one layer being a gel polymer with   
   fallopian tube and egg scent/flavor added to it, then with a depthy filter,   
   similar to an egg carton    
   placed on top of it is able to allow only those sperm that fit through the egg   
   carton holes to reach the flavor layer; the flavor layer also has a sperm   
   terminating chemical like nonoxynol 9 (or something better), so, larger sperm   
   while attarcted to the    
   egg carton laminate cannot fit through the holes and bounce off of it, to   
   continue seeking an opportunity to fertilize; noting that female sperm are   
   larger, if it is experimentally verified they are fertile and normal, the   
   99.99th percentile of largest    
   sized sperm are likely to be disproportionately female, optimally 99%+ female,   
   so with a plurality of very minute duopolymer egg carton Y chromosome sperm   
   terminating assemblies, of perhaps 60-100 microns deep (from holes to scented   
   poison) and at least    
   100 microns width and breadth, I am reminded of approximately 1x1mm pieces of   
   edible glitter in various products; that is about 100 sperm terminating   
   assemblies per mm^2, so 100,000 pieces of glitter in a sexual lubricant that   
   sex selects to favor the    
   conception of female babies would sequester and terminate 10 million sperm; as   
   a typical ejaculate is near 60 million sperm it is better to have a system   
   that can terminate up to 200 million sperm; one possibility is a poison and   
   scent core, externally    
   egg-crated entrance screen cellulose fibers that are embossed (made) while   
   dry, then become viscid, slippery, and pleasant at a sexual lubricant when   
   introduced into the vagina (some cellulose forms are gooey);  The number of   
   ingress and terminate    
   pathway egg crates, each of which terminates 1 sperm, there could be at a 10%   
   cellulose fiber solution, is likely to be a whole bunch, possibly more than   
   several hundred million; an entire 14 grams (1/2 oz) of sexual lubricant might   
   have a really really    
   large amount of sperm terminating assemblies. Notably the 99.99 or 99.999th   
   percentile of sperm largeness keeps them out of the egg crate assemblies and   
   they can swim to reach the egg and fertilize it   
      
   A highly similar system can be produced that lasts all month, or several   
   months, and is possibly 1-2 cents made from alibaba.com parts; A cervical cap   
   is a polymer cup that fits over the cervix tightly enough to keep out all   
   sperm, and can be worn all    
   month, being taken out only for mestruation.  Placing sorted sperm or also   
   genetically enhanced sperm, or also genetically optimized sperm in a cervical   
   cup and wearing it assures that sperm seeking the fallopian tubes and eggs   
   will ne near the cervix    
   and continuously available many days before ovulation, during ovulation and   
   after ovulation, increasing the likeliness of getting pregnant; the 1 month or   
   longer durability of the sperm is suggested by a published thing that I think   
   actually said that at    
   microencapsulated live sperm they had 100% viability after 30 days (but were   
   cooled 15C), that suggests that even if 5% of the sperm survive a month at   
   body temperature in the microcapsule, getting pregnant all month is possible;   
   The emphasis here is    
   convenience and getting to skip keeping track of calenders, you just pop it in   
   and it works. That is also particularly beneficial for people getting sperm   
   bank sperm; the sperm arrives in a cervical cap, you let the cervical cap thaw   
   for 40 minutes, pop    
   it in and you have done your part to get pregnant for the month, additionally   
   as a cervical cap is contraceptive to sperm outside of of it, you can have sex   
   with your exisitng partners and lovers as usual and still get pregnant with   
   the sperm bank sperm;    
   another benefit from having the sperm right next to the cervical canal is that   
   it likely takes just a few well positioned microliters to cause a pregnancy,   
   making particularly gifted donors able to donate to thousands (2Ml = 2000   
   microliters)   
      
   A technology that increases the number of sperm that make it up the cervix   
   toget nearer the egg is using a proteolytic (protein dissolving) enzyme that   
   only effects mucoproteins like those found in cervical mucous, as part of the   
   technology these    
   proteolytic enzymes do not have an effect on the sperm, It may be that full   
   mucolysis (all the mucous gone) is less than say 80% of the mucous dissolved   
      
   A further technology that could assist the sperm in reaching the egg is making   
   the sperm’s chemoreception (smelling ability) better; antibodies, tail   
   proteins, two sample chemoreceptors   
      
   It might be possible    
      
   At sperm bank sperm it would be highly beneficial to know the genetic contents   
   of a single sperm before it was used for fertilization, and to be able to sort   
   a diluted ejacualte into separate fractions each with different desiable   
   genetics so that the    
   sperm bank client can choose to get the largest number of her criteria   
   (longevity, intelligence, beauty, others) simultaneously; DNA is all coiled up   
   at a sperm,    
      
   Three systems that could actually look at the genes in the sperm while   
   maintain sperm fertility and motility are 1) quantum camera 2) something a   
   little like a deuterated primer (1/2 DNA ladder) attached to a quantum dot 3)   
   A nestling custom protein with    
   an IR spectroscopy spectrum, 4) has anybody tried laser tweezers that shine   
   through a sperm to move around the things inside the sperm   
      
      
   Identicality, then dissasemble sample, might work, maybe sperm are clonal, if   
   you have 32 identicals and know it you can gene sequence on and extrapolate to   
   the remaining 31   
      
   --- SoupGate-Win32 v1.05   
    * Origin: you cannot sedate... all the things you hate (1:229/2)   

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