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|    sci.chem    |    Chemistry and related sciences    |    55,615 messages    |
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|    Message 55,207 of 55,615    |
|    Treon Verdery to All    |
|    Longevity technology (1/8)    |
|    30 Sep 22 05:56:10    |
      From: treon3verdery@gmail.com              GSK              Peelies from sun exposure relief technology: 10hda is published as reducing       scratching multiple times; screen a decanoic ester library, that finds a       molecule that does better than the multiple times less scratching that nude       mice do when they have        dermatitis and have royal jelly topically applied to them while being at       greater potency per mg or microgram, Put some kind of dermis passing thing on       or with it, beauty emulsions say they penetrate the dermis to bring active       ingredients to the dermis so        those technologies can bring decanoic acid esters to the living part of the       dermis              so it can soak through the peelie and get to the itchy live dermis under the       peelie. I have also read multiple pubmed journal references comparing topical       dermis youthifiers and the references say some of them are highly functional       so dermal transport        media or moieties are to my perception functional              Oral version              Topically, harmless antibodies linked to fluoroethynyl phenibut like chemical,       could possibly concentrate at the dermis.              An oral version with enteric coated liposomes to deliver the protein conjugate       drug could take numerous minutes to reach the small intestine but make people       feel better for many hours and as a pill is more likely, I perceive, to be       utilized.              The possibility of a fluoroethynyl peptide or a harmless antibody linked       peptide suggests less than 100 micrograms would dose the entire volume of a       70kg body, so a few kg of dermis is likely less than 11 micrograms per       application, at $435/g (retail        antibodies) that is near 43.5 cents a milligram or near .0435 cents per       topical dose or .29 of a cent per oral dose              Is there such a thing as well feeling and appearing dermis, itchless and zero       hue change skin puffiness causing chemical; one possibility that is similar       but kind of different is topical vasodilator, possibly niacin, which i       perceive i may have read        about as a topical beauty treatment; if there is then doubling fluid flow at       the capillary epithelia could make a topical peelie comfort medicine absorb       twice as rapidly or ultra hydrate the dermis causing more rapid diffusion and       greater activity of the        topical drug causing more rapid function; I have heard of vasoactive peptides,       perhaps they could function;              A zero hue change completely comfortable dermal vasodilator might also double       the effectiveness of things like peptide beauty topicals, it makes me think       though, they could just double the amount of active ingredient;               Find out if topical or oral phenibut, possibly a halogenated phenibut, or GABA       active peptide effects dermal nerves to cause the removal of itching that       about 2 grams of oral phenibut causes. A body side of the blood brain barrier       possibly halogenated        phenibut or other body side of the blood brain barrier GABA active molecule       could omit CNS GABA activities, it is beneficial to have the drug be absent       effects on things like driving ability, reaction time, or social skills.              Thick throat coating drink with peptides might have sufficient surface area to       be absorbed as a kind of oral-like peptide dosing form, although I have heard       of peptide doses up to 1 mg my perception is that at things like vasopressin       and oxytocin it is        much less, the most dose effective peptide I have read about, having not       looked up other things is a mu opioid peptide active at nanogram amounts, I       perceive I read about a halogenated peptide that was twice as effective; at an       oral like mouth and throat        coating peptide dosing form it is possible the pH of throat saliva could be       modified and a mucolytic thing, perhaps something like a protease that is       absent an effect on the peptide could make the peptide actually contact the       dermis at the throat and        mouth, the thing is though, what about stirring? A mm layer of colorant will       just sit at a glass, for I perceive, hours, before diffusing; effervescence       could do it, so perhaps a bubbly mini-beverage could make the body surface       dermis soothing peptide        reach the throat mucosa dermis many times more rapidly and before it was       washed to the stomach; beneficially the peptide would only work at the mouth       and throat so if many doses were consumed because the bubbly mini-beverage       tastes good the dose would        not vary that much              The 1/10 of a cent printed paper dose technology with the 1 cm^2 doses and       enteric layered ink could be beneficial at the developing world, the thing is,       what drug, like antibody linked GABA active peptide or drug, would soothe the       dermis; tetracycline        and possibly minocycline do build up at the dermis, possibly a GABA active       drug linked to one of those molecules that has been screened to be a neutral       biotic, possibly also finding a variant with greater dermal localization              An all natural product could also function, I do not know of any anaesthetic       macroscopic or other fungi, but if there are any, notably GABA receptor active       fungi chemicals, then those could be a rapid product.              Actually I am not aware of any natural product that effects GABA receptors,       there are commercial natural products chemical libraries that exist, they       could screen those to find out if any of the natural products effect GABA       receptors, GABA the chemical        does not pass the blood brain barrier but might diffuse through the dermis and       is only a few $ per 100g.              Other neurotransmitters at the dermis could be anesthetizing, heightening       response of anadamide receptors is unknown, a mu-opiate peptide that       disintegrates in saliva, mucous of any orifice, and the stomach could be a       topical anesthetic, perhaps a mu        opiate peptide with a magnesium or calcium or zirconium or scandium atom in       the middle of it could persist long enough at the dermis, or lasting about 90       seconds, but continually diffusing from the topical material would function              Orally a mu opioiod peptide attached to a harmless dermal              Localizer molecule, possibly an antibody or a minocycline variant could       function. As a topical drug the peptide could be modified so that many enzymes       degrade it so it would be nonseperable from the localization chemical which       might also be made of        enzymatically degradable nucleotides, peptides or proteins              Things that soothe UV Elie's could ask soothe dermatitis as well as a topic       dermatitis              Theoretically about7.6 billion people on earth have experienced sun based       peelies, so this could benefit people                     [continued in next message]              --- SoupGate-Win32 v1.05        * Origin: you cannot sedate... all the things you hate (1:229/2)    |
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