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   sci.chem      Chemistry and related sciences      55,615 messages   

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   Message 55,207 of 55,615   
   Treon Verdery to All   
   Longevity technology (1/8)   
   30 Sep 22 05:56:10   
   
   From: treon3verdery@gmail.com   
      
   GSK   
      
   Peelies from sun exposure relief technology: 10hda is published as reducing   
   scratching multiple times; screen a decanoic ester library, that finds a   
   molecule that does better than the multiple times less scratching that nude   
   mice do when they have    
   dermatitis and have royal jelly topically applied to them while being at   
   greater potency per mg or microgram, Put some kind of dermis passing thing on   
   or with it, beauty emulsions say they penetrate the dermis to bring active   
   ingredients to the dermis so    
   those technologies can bring decanoic acid esters to the living part of the   
   dermis   
      
   so it can soak through the peelie and get to the itchy live dermis under the   
   peelie. I have also read multiple pubmed journal references comparing topical   
   dermis youthifiers and the references say some of them are highly functional   
   so dermal transport    
   media or moieties are to my perception functional   
      
   Oral version   
      
   Topically, harmless antibodies linked to fluoroethynyl phenibut like chemical,   
   could possibly concentrate at the dermis.   
      
   An oral version with enteric coated liposomes to deliver the protein conjugate   
   drug could take numerous minutes to reach the small intestine but make people   
   feel better for many hours and as a pill is more likely, I perceive, to be   
   utilized.   
      
   The possibility of a fluoroethynyl peptide or a harmless antibody linked   
   peptide suggests less than 100 micrograms would dose the entire volume of a   
   70kg body, so a few kg of dermis is likely less than 11 micrograms per   
   application, at $435/g (retail    
   antibodies) that is near 43.5 cents a milligram or near .0435 cents per   
   topical dose or .29 of a cent per oral dose   
      
   Is there such a thing as well feeling and appearing dermis, itchless and zero   
   hue change skin puffiness causing chemical; one possibility that is similar   
   but kind of different is topical vasodilator, possibly niacin, which i   
   perceive i may have read    
   about as a topical beauty treatment; if there is then doubling fluid flow at   
   the capillary epithelia could make a topical peelie comfort medicine absorb   
   twice as rapidly or ultra hydrate the dermis causing more rapid diffusion and   
   greater activity of the    
   topical drug causing more rapid function; I have heard of vasoactive peptides,   
   perhaps they could function;   
      
   A zero hue change completely comfortable dermal vasodilator might also double   
   the effectiveness of things like peptide beauty topicals, it makes me think   
   though, they could just double the amount of active ingredient;    
      
   Find out if topical or oral phenibut, possibly a halogenated phenibut, or GABA   
   active peptide effects dermal nerves to cause the removal of itching that   
   about 2 grams of oral phenibut causes. A body side of the blood brain barrier   
   possibly halogenated    
   phenibut or other body side of the blood brain barrier GABA active molecule   
   could omit CNS GABA activities, it is beneficial to have the drug be absent   
   effects on things like driving ability, reaction time, or social skills.   
      
   Thick throat coating drink with peptides might have sufficient surface area to   
   be absorbed as a kind of oral-like peptide dosing form, although I have heard   
   of peptide doses up to 1 mg my perception is that at things like vasopressin   
   and oxytocin it is    
   much less, the most dose effective peptide I have read about, having not   
   looked up other things is a mu opioid peptide active at nanogram amounts, I   
   perceive I read about a halogenated peptide that was twice as effective; at an   
   oral like mouth and throat    
   coating peptide dosing form it is possible the pH of throat saliva could be   
   modified and a mucolytic thing, perhaps something like a protease that is   
   absent an effect on the peptide could make the peptide actually contact the   
   dermis at the throat and    
   mouth, the thing is though, what about stirring? A mm layer of colorant will   
   just sit at a glass, for I perceive, hours, before diffusing; effervescence   
   could do it, so perhaps a bubbly mini-beverage could make the body surface   
   dermis soothing peptide    
   reach the throat mucosa dermis many times more rapidly and before it was   
   washed to the stomach; beneficially the peptide would only work at the mouth   
   and throat so if many doses were consumed because the bubbly mini-beverage   
   tastes good the dose would    
   not vary that much   
      
   The 1/10 of a cent printed paper dose technology with the 1 cm^2 doses and   
   enteric layered ink could be beneficial at the developing world, the thing is,   
   what drug, like antibody linked GABA active peptide or drug, would soothe the   
   dermis; tetracycline    
   and possibly minocycline do build up at the dermis, possibly a GABA active   
   drug linked to one of those molecules that has been screened to be a neutral   
   biotic, possibly also finding a variant with greater dermal localization   
      
   An all natural product could also function, I do not know of any anaesthetic   
   macroscopic or other fungi, but if there are any, notably GABA receptor active   
   fungi chemicals, then those could be a rapid product.   
      
   Actually I am not aware of any natural product that effects GABA receptors,   
   there are commercial natural products chemical libraries that exist, they   
   could screen those to find out if any of the natural products effect GABA   
   receptors, GABA the chemical    
   does not pass the blood brain barrier but might diffuse through the dermis and   
   is only a few $ per 100g.   
      
   Other neurotransmitters at the dermis could be anesthetizing, heightening   
   response of anadamide receptors is unknown, a mu-opiate peptide that   
   disintegrates in saliva, mucous of any orifice, and the stomach could be a   
   topical anesthetic, perhaps a mu    
   opiate peptide with a magnesium or calcium or zirconium or scandium atom in   
   the middle of it could persist long enough at the dermis, or lasting about 90   
   seconds, but continually diffusing from the topical material would function   
      
   Orally a mu opioiod peptide attached to a harmless dermal   
      
   Localizer molecule, possibly an antibody or a minocycline variant could   
   function. As a topical drug the peptide could be modified so that many enzymes   
   degrade it so it would be nonseperable from the localization chemical which   
   might also be made of    
   enzymatically degradable nucleotides, peptides or proteins   
      
   Things that soothe UV Elie's could ask soothe dermatitis as well as a topic   
   dermatitis   
      
   Theoretically about7.6 billion people on earth have experienced sun based   
   peelies, so this could benefit people   
      
      
   [continued in next message]   
      
   --- SoupGate-Win32 v1.05   
    * Origin: you cannot sedate... all the things you hate (1:229/2)   

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