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   sci.chem      Chemistry and related sciences      55,615 messages   

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   Message 55,243 of 55,615   
   Treon Verdery to All   
   Theoretically it is possible to get the    
   01 Oct 22 00:10:24   
   
   From: treon3verdery@gmail.com   
      
   3d printed needles could have many side pores at the sides of the distal   
   delivery tip, spreading the high pressure stream into a diffusion area of .1-2   
   mm at the sides equivalent to plunger pressure standard hypodermic needle   
   fluid deposition velocities   
      
   One possible application of a pressurized hypodermic needle with full needle   
   flow delivery is cosmetic procedures, aside from the face this could also be   
   applied at depth to the breasts   
      
   1/10 diameter tube with 1/7 diameter fiber optic and sonographically contrast   
   labelled tip could allow precise micro positioning of the needle, particularly   
   during cosmetic procedures, if a regular needle is .7mm then this needle would   
   be .08mm diameter    
   but still deliver the same amount of fluid, and could be steered to precise   
   locations   
      
   Motorized (electric pump) pipettors are $49-69 on eBay and alibaba so similar   
   technology could be the same or less, noting only the needle (and perhaps,   
   like a pipettor, the fluid reservoir) could be disposable   
      
   Such a 1/10 diameter pressurized syringe needle with sonography contrast   
   enhanced tip could be used to inject support and perkiness enhancing chemicals   
   into the breasts making them match measurements of the person's breasts taken   
   when they were 15-16,    
   there are a number of chemicals that could do this, chemicals that are growth   
   factors for supporting tissues, another possibility is the non carcinogenic   
   injection of something that causes non-stretch .1-.5mm wide scar tissue deep   
   at the breast far from    
   the skin   
      
   Similarly pumped 1/10 diameter needles could be used to do medical procedures   
   on joints or be used at things like chemotherapy of brain and other tumors   
      
   It is also possible a 1/10 usual diameter hypodermic needle with a pressurized   
   fluid delivery would be more comfortable to experience   
      
   Treating depression at the developing world could be more effective with 1/10   
   of 1¢ drugs printed on paper, available without prescription, as described in   
   my imaged notes, you use an inkjet printer to print 604 1 cm drugged paper   
   squares on a 11¢    
   piece of specialized paper, this accompanies the idea that some group of   
   drugs, when halogenated, ethynyl group modified,and attached to a cytomembrane   
   passing moiety or peptide each make the drug 10 times more potent, multiplied   
   that is 1000 times    
   stronger pharmaceuticals per milligram, so most drugs with a 200 mg dose would   
   become 200 microgram doses printable with an inkjet printer on 1 centimeter   
   squares,   
      
   Fluorinated ethynylized, cytomembrane passing optimized bupropion (wellbutrin)   
   could be 10fluorine*10ethynyl*10cytomembtane passing is 1000 times more potent   
   as mg per dose than wellbutrin, changing it from 68¢ a dose (retail) to 6.8   
   tenths of one ¢    
   printable on paper with an inkjet printer, making this available globally   
   could alleviate depression in 180 million people globally, this    
   luorine/ethynyl/cytomembrane/inkjet approach could also be used on other   
   antidepressants but I favor buproprion    
   because it omits effecting sex drive or even increases it and may be a better   
   than well drug for those without depression   
      
   St johns wort (hypericum extract) is otc and treats depression, they could   
   find yeast that hydroxylates or replaces hydroxyls with hydrogens   
   (dehydroxylase) at the st johns wort chemicals like hyperforin then test to   
   find out if any of these all natural    
   OTC friendly products are better at relieving depression as well as find out   
   if any of the metabolites of hypericum found at urine are physiologically   
   active at reducing depression, I do not know if cow pee extract is   
   automatically OTC or not, these all    
   natural products may appeal to those who are shy of doctors or in some   
   geographic regions   
      
   Is there a Trace Amino Acid Receptor based antidepressant, could there be one?   
   Molecular variations on ADD (attention deficit disorder) drugs might do this   
   as well as phenylethylamine. (PEA, PEA makes me cheerful at get high dosages   
      
   Molecular variants of caffeine that have brain localization moieties or   
   peptides attached to them could stimulate just particular areas of the brain   
   or particular kinds of neurons, wikipedia says "caffeine is an antagonist at   
   all four adenosine receptor    
   subtypes (A1, A2A, A2B, and A3), although with varying potencies.[6][141] The   
   affinity (KD) values of caffeine for the human adenosine receptors are 12 μM   
   at A1, 2.4 μM at A2A, 13 μM at A2B, and 80 μM at A3.[141] Knockout mouse   
   studies have    
   specifically implicated antagonism of the A2A receptor as responsible for the   
   wakefulness-promoting effects of caffeine.[141] Antagonism of adenosine   
   receptors by caffeine stimulates the medullary vagal, vasomotor, and   
   respiratory centers, which    
   increases respiratory rate, reduces heart rate, and constricts blood   
   vessels.[6] Adenosine receptor antagonism also promotes neurotransmitter   
   release (e.g., monoamines and acetylcholine), which endows caffeine with its   
   stimulant effects;[6][142]    
   adenosine acts as an inhibitory neurotransmitter that suppresses activity in   
   the central nervous system. " that makes it seem like precluding adenosine   
   build up at particular locations could have numerous medical benefits, perhaps   
   an antidepressant that    
   localizes which prevents jitteriness, grouchiness but keeps depressed people   
   from day sleeping and makes them cheerful, other possibilities are nootropics   
   and weight loss drugs   
      
   Localization molecular variations of many known and new drugs could produce   
   many beneficial effects location or cytotype uptake specific and efflux   
   moieties are previously described, what wikipedia describes as adenosine A1-A3   
   receptors may differ in    
   different amounts at different neurons, molecular variants that concentrate at   
   these preferentially could be localized drugs, also many strategies and   
   moieties are used to get past the blood brain barrier, so A1-A3 localization   
   with a BBB pass moiety    
   like chlorophenoxy could keep the dose low and out of the rest of the body   
      
      
   [continued in next message]   
      
   --- SoupGate-Win32 v1.05   
    * Origin: you cannot sedate... all the things you hate (1:229/2)   

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