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|    sci.chem    |    Chemistry and related sciences    |    55,615 messages    |
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|    Message 55,290 of 55,615    |
|    Treon Verdery to All    |
|    Longevity technology (1/2)    |
|    02 Oct 22 05:03:48    |
      From: treon3verdery@gmail.com              Rapamycin is a nootropic that can heighten laboratory mammal cognition and can       keep me awake, brain positron emission tomography could find out which neuron       types, and at what brain location these effects occur from, other nootropics       that activate these        areas could be screened for longevizing effects, also if rapamycin is       concentrating at some regions of the brain, or some neurotransmitter types and       not others then a molecular variant of rapamycin that goes to all brain areas       and all neurotransmitters        could be found                             Longevity gene, neuron types where one neuron uses a particular        eurotransmitter or just all the cytes at the body could use epigenetic       modification drugs to make fewer mTOR receptors and possibly increase the       amount of AMPK receptors at neurons, causing        the CNS to be more youthful possibly causing longer duration of youthful mind,       and youthful cognition, and youthful emotion, cardiovascular system cytes       could also be beneficial, causing greater longevization, youthspan of the       heart and vasculature, this        could be a one dose drug that prevents cardiovascular disease                            Create epigenetics that reduce activity of mTOR receptor producing genes, and       possibly heighten production of AMPK from AMPK genes, possibly through       screening a million or to find an even more optimal epigenetic modifier, tens       of millions of molecular        variants of epigenetic modifying molecules to one that is most specific to       downregulating mTOR, and up regulating AMPK, this could have multi generation       longevizing effects, germline or also oocytes and spem modification to have       the epigenetics of        longevity is beneficial                            Modifying the genetics of cytes used at nuclear transfer to oocytes to have       mTOR epigenetics that cause greater longevity              Liposomal ultra micro reactors              Aluminum or other atom hydrophilic or electrically charged head, or at another       solvent like NH3 or DMSO, Or silicone oil, charged silicone distal       electronegativity oil, make liposomes or things like silicosomes with       reactants at the liposome or        silicosomes cores, sequential liposome or silicosome dipping might even       combine reactants that are non able to occupy the same flask, then a       detonation, warmth occurrence, photochemistry, like lasers event, or radiation       occurs and the comparatively few        atoms interior to the liposome react to form a product at the core of the       liposome, liposomes are kind of see through and liposomes can be sorted with a       spectrophotometer at a thing like a flow cytometer, or possibly liposomes or       silicosomes could have        surface charge that varies with core contents possibly from making the       silicosome with 1/100th highly C=C saturated with NH on it or zubbles (TM a       kind of plaything) like chalcones, which are so responsive that without       disintegrating they change color        based on surface tension) then based on what is in the liposome the surface       chemistry differs facilitating sorting, a trillion liposomes with 1000       reaction production product molecules each makes about 2^14 atoms or a       billionth of a mole, at a 100 amu        product that is 1 microgram of product, flow cytometry to centrifuge                            Silicosomes can be made with solventophilic heads and multimers with       electronegative (like nitrogen, phosphorus, metals, Se ) atom heads, it is       possible to omit carbon funkiness (what happens after an actual lipid liposome       is warmed or disintegrated with        light or radiation), the non interactivity of the reactant molecules with the       Si silicosomal interior perimeter makes things cleaner                            The reacted silicosomes do a laser spectroscopy and flow cytometry like       traversal of a tube and are sorted into products, so a reaction that yielded       100 products then produces 100 different separated products, possibly a       million at a microfluidic device (       a million channel microfluidic chip I read about), and if these are products       like longevity chemicals they can then move to an organism area to find out if       they are longevizing, so 1 million varieties of halogenated rapamycin can be       silicosomal reaction        produced, spectroscopy sorted, then applied to yeast or human tissue culture       microfluidically, a trillion silicosomes could be 1 microgram of product, at a       300 mm wafer with 10-100 billion wells per chip, 1 million variants of       longevity molecules tested        per notable source, things like endolith chemicals autovariationized is 10k       sou                            Longevity technology              Yeast have longevity chemical responses, find another organisms, possibly even       another yeast, that responds like yeast to a library of 10k different       chemicals but has a 4 hour lifespan, also verify that when tested at the 4       hour lifespan 40-100 different        longevizing remain longevizing, then use that organism to screen new       longevity chemicals in just 4800 minutes to 240 minutes each, so at the       reacted sorted liposomes microfluidically connected to a 10 billion well yeast       IC plate then after just 1/3 of a        day you would be able to know longevity had more than doubled, and based on       well location, which chemicals were associated with the longevity heightening,       and then make a completely new liposomal reaction 10 billion chemical library       to screen on another        plate, that screens about 30 billion new longevity chemicals each 24 hours or       1 trillion new longevity chemicals a month                             Are buckycup liposomes possible              That's like 1 nm or less buckycup like electron wave concentrating       semiconductor manufacturing chemical or nano technological reaction/assembly,       integrated circuit technology geometries technology                            Noting 1 nanometer dots are likely possible with 3nm integrated circuit       feature technology with a more casual error rate, then a 300 mm wafer has       about 9 times 10^12 one nanometer features, a 1 nm diameter well 5000 nm deep       (5 micrometers) is a stack        5000 molecules deep and one molecule wide (carbon 120 picometers, about 9       carbons to a well width) that could be sequentially piled up in the well to a       depth and volume of 45,000 molecules, this makes me think of things like, load       it up, use radiation to        initiate reaction or polymerization, or radiation to divide things like       halogen atoms from their molecules to do new reactions, or load some areas       with catalytic molecules like electrically addressable liquid crystal       molecules with cobalt or Rh atoms on        it to do chemistry, may also be cycled between a temperature with 1/2 the       reaction rate and one with the full reaction rate to load it when cool, light       and charge based reactions are also cool,                                   [continued in next message]              --- SoupGate-Win32 v1.05        * Origin: you cannot sedate... all the things you hate (1:229/2)    |
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