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|    sci.chem    |    Chemistry and related sciences    |    55,615 messages    |
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|    Message 55,302 of 55,615    |
|    Treon Verdery to All    |
|    Longevity technology: (1/2)    |
|    02 Oct 22 08:14:36    |
      From: treon3verdery@gmail.com              the King’s Holly has lived 1.46 million days thus far, other trees have a       lifespan of just 3650 days, ceasing to be alive even before a human reaches       puberty; Finding longevity drugs based on the 400,000 percent different       longevity difference between        trees goes with doing HPLC, something better than electrophoresis like laser       spectroscopy, electrophoresis or some other thing, to find all the chemicals,       proteins, peptides, lipids, in the plants, as well as at human tissue, then       finding those chemicals,        proteins, peptides, lipids difference between the 1.46 million day longevity       plant, the 3650 day plant, and the human;                             I read humans share 60% of their genome with the banana, that suggests some       plant genes, and plant gene products, and the amount of those chemical plant       gene products, have most longevizing molecule versions that can be quantified       as to longevity effects        at yeast and mice;                             finding longevity chemicals: the group of chemicals (and genes) at both the       (3650 day tree and the human) that are different than the chemicals that the       (kings holly and the human share) are places where the chemicals (and the       genes) at the humans could        improve and the king’s holly is the source of improvement;                            At homologous genes an organisms that noticed it had the 3650 day plant       version rather than the kings holly would notice an opportunity to have more       longevizing chemicals endogenously produced                            finding longevity chemicals: dosing yeast and mice with the chemical that the       kings holly gene makes, that the human does not, noting the homologous but       different gene, could find longevity drugs;                             engineering mice and yeast to make that shared homologous kings holly gene       then finding out if it longevizes them produces new longevity genes                            This same approach works for finding longevizing chemicals between groups like       million year lifespan endoliths comparison grouped with similar-to-endolith       with different habitat organisms with 365 day lifespans, 214 year old whales,       and whales with        briefer lifespans, 400 year lifespan clams, and clams with annual lifespans,       and supercentenarian humans with 18 year marmosets;                             The genes and gene products (chemicals) that the 400 year clam shares with the       annual clam are ignored when narrowing the list of chemicals and genes at the       human to find 400 year clam genes with longevity effects;                            Now, although the amount of the chemicals matters the same thing can be done       with chemicals, proteins, peptides, and lipids at the bodies of the various       trees and other organisms                            If the chemical is the the 3650 day plant and the king’s holly, ignore it,       if it is only at the king’s holly put it in a database;                            This works better at varieties of the same species with widely varying       lifespans, if there are any species that interbreed but have 2-4 times       different longevity, then ignoring the chemicals they share, then making a       database of the chemicals only at the        long lived variety, then at humans finding if any of the database chamicals                             There is a thing here though that kind of makes it improvable, for each 14       million chemicals the kings holly contains, and the 3650 plant overlaps 90% of       them, that is still 1.4 million chemicals that might have longevity effects;                            I think geneticists who write computer programs already know all about this,       but if you have like 100 groups of related-organisms pairs (king’s holly       3650 day tree),(mouse, beaver), (214 year whale, less longevity whale),       (human, primate with 1/5th        human lifespan) with the group members as far apart as possible as to       longevity, and then compare the amount the very different most long lived       species converge towards each others gene versions, notably moving away from       their species-similar organisim,        then you find a possible math convergence around better versions of genes, or       better versions of physiochemicals                            The high longevity organisms at each of the 100 bowls of 2 or 3 longevity       heterogenous organisms each                             This technique can be used for other things like, 100 bowls of 2 or 3 mammals       each, and the species similar mammals differ as much as possible on behavior,       then you look at how the bowl leaders (of very different species) converge on       various        characteristics, these can be genes, fMRI of brain areas, even things like       parenting styles; a human, or niftily, a deep learning AI can then make a       list of trends                            (Mathematically you would expect the beaver to be more like the mouse, but if       the beaver is more like the whale, the human, and the King’s holly then       there might be a longevity trend at that homologous gene, similarly you might       expect a human to be        more like a marmoset than a whale or the king’s holly, but at genes where       the king’s holly is more similar that could suggest a “different chemical       is better” trend, then noting the upper longevity organisms at each of the       100 bowls each with two        or three species in them (mouse beaver, 214 year whale, less longevized whale)       (longevized bat, less longevized bat) (human, primate with 1/5th human       longevity)                            The 100 bowls of three high distalness (long lived, otherwise) yet each bowl       with similar species could be repeated at species that have particularly wide       longevity ranges, perhaps birds as well; if this finds a longevity trend for a       group of genes at        very different birds, then the genes the different bowl gnes most share                            also the 100 bowls thing of 2 or 3 organisms thing works with longevity       chemicals as well, if 100 bowls find like 5000 circulatory chemicals shared at       the long lived organisms out of each bowl, then those 5000 chemicals are       compared to the chemicals in a        human, any of the 100 bowl shared longevity chemicals the human does not (yet)       have could be tested on yeast and mice and human tissue culture to find out if       they are longevizing; this works with homologous genes as well, if you have       100 bowls of clams,        birds, sharks, endoliths, plants, and other things, and the distal organisms       in each bowl have and above-chance occurence of shared genes, then those could       be longevity genes and a human would compare their genome to that shared at       the 100 bowls of very        different species; mathematically it would be possible to list in order the       genes shared between bowls, and the longevity trend of just that group of       bowl-set organisims, so it would be possible to find the likely most       longevizing versions of the bowl-       shared genes;                                   [continued in next message]              --- SoupGate-Win32 v1.05        * Origin: you cannot sedate... all the things you hate (1:229/2)    |
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