From: treon3verdery@gmail.com   
      
   liposome formulations showed a mean diameter in the range of 175 nm to 219 nm   
   with polydispersity index lower than 0.22, a lightly negative zeta potential   
   and excellent encapsulation efficiency. Moreover, along with good mucoadhesive   
   properties,    
   multifunctional liposomes showed a markedly increase in tacrine permeability,   
   which can be related to liposome fusion    
      
   with cellular membrane,   
      
      
      
   C-Pc liposomes were more effectively taken up by Neuro2a cells than free C-Pc   
   and were biocompatible, maintaining the anti-oxidative properties of C-Pc.   
   When optimal C-Pc liposomes were administered to middle cerebral artery   
   occlusion (MCAO) rats 2 h    
   after onset, infarct sizes were smaller and behavioral activities improved   
   compared with the same metrics in free C-Pc-treated rats. Liposomal delivery   
   still reduced infarct sizes and improved behavioral activity 6 h after onset,   
   whereas free C-Pc did    
   not.   
      
      
      
   Intranasal liposomes had a longer half-life in the brain than intranasally or   
   orally administered free drug   
      
      
      
   Piperine is an antidepressant works better as a snortable liposome,   
   “Antidepressant and cognitive effects of piperine-en- capsulated liposomes   
   (PL) were investigated in male Wistar rats. Oral piperine (5 mg/kg body   
   weight/day) and intranasal PL (7.2 μ   
   g/day) were randomly as-signed to daily administer for 14 days to rats which   
   were subjected to forced swimming, Morris water maze and spontaneous motor   
   behavior tests. PL sig-nificantly exhibited anti-depression like activity and   
   cognitive enhancing    
   effects, in comparison to the con-trol groups after the first dose (p < 0.01)   
   and the ef-fects could be maintained throughout the period of study.   
   Quantitative analysis of the brain homogenates by HPLC indicated that   
   piperine, delivered either orally or    
   nasally, distributed to the hippocampus at a higher extent than the cortex and   
   that the time to peak concentration of nasal PL was shorter than for the oral   
   piperine. Intranasal PL was, thus, potential in delivery of piperine, at a low   
   dose, to exert its    
   an-tidepressant and cognitive enhancing activities.”   
      
    siRNA drugs can be administered with liposomes, “ntranasal delivery of the   
   siRNA targeting Beclin1 significantly depleted the target protein expression   
   levels in brain tissues with no evidence of toxicity.”   
      
      
      
   we developed a nose-to-brain delivery system combined with cell-penetrating   
   peptide (CPP), Cell-Penetrating Peptides (CPPs), also known as protein   
   transduction domains (PTDs), membrane translocating sequences (MTSs), and   
   Trojan peptides are short    
   peptides (≤40 amino acids), with the ability to gain access to the interior   
   of almost any cell. They are highly cationic and usually rich in arginine and   
   lysine amino acids. They have the exceptional property of carrying into the   
   cells a wide variety    
   of covalently and noncovalently conjugated cargoes such as proteins,   
   oligonucleotides, and even 200 nm liposomes.   
      
      
      
   melatonin antidepressants, mood elevators exist, “Agomelatine is a   
   structural analog of melatonin”, it is possible that like tyhe pineal   
   peptide AEDG causes greater longevity molecular variations of these mood   
   improving drus could be simulataneously    
   longevizing and mood improving, “agomelatine. Agomelatine is a melatonergic   
   agonist and a 5HT2c antagonist (i.e., it has a unique mechanism of action).   
   The melatonergic function appears to improve sleep patterns, whereas the   
   serotonergic antagonism    
   results in the release of norepinephrine and dopamine.”   
      
      
      
   Previously described is finding the genetics of having good dreams, I favor   
   making the genetics of having good dreams part of the human germline, also,   
   amount persons above the 99th percentile of longevity they could find those at   
   the 99% of having    
   actively good dreams and an absence of dreams the person would prefer to have   
   skipped, this is a guide to finding the genetics of more beneficial sleep, it   
   may even be possible that there are those at the 99th percentile of longevity   
   who dream twice as    
   much as others, dreaming good dreams twice as often is beneficial to humans   
   and is beneficial to make a part of the human germline   
      
      
      
   g (like IQ) gene “klotho-enhanced mice performed better on a variety of   
   learning and memory tests, regardless of age. In one test, the mice remembered   
   the location of a hidden target in a maze better, which allowed them to find   
   it twice as fast as    
   control mice.”   
      
   --- SoupGate-Win32 v1.05   
    * Origin: you cannot sedate... all the things you hate (1:229/2)