From: treon3verdery@gmail.com   
      
   How many sequential doses of an epigenetic drug cause the epigenetic   
   improvement? Liposomal depot, perhaps attached to an antibody that gloms it to   
   the surface of the lining of the lymphatic compartment could diffuse   
   beneficial drugs, although that seems    
   complex. One possibly as is epigenetic modifying drug palmitate. I do not know   
   if the longevity effects of 10HDA(10H2DA) are from HDAC interference and   
   epigenetic, but if they are then taking a high dose of 10HDA once a month (or   
   some other interval), or    
   like 30 grams of royal jelly which has 10HDA(10HDA) for two or three days once   
   a month could have the same or better longevity effect. There is the   
   possibility that occasional high dose 10HDA(10H2DA) or royal jelly is actually   
   more longevizing from being    
   thorough and of higher activity.   
      
      
      
   One HDAC2 inhibitor is a nootropic. It is possible that one or two high doses   
   of that HDAC inhibitor a month could   
      
   Cause greater cognitive ability.   
      
      
      
   Notably though there is another version of this. I read histone epigenetics   
   like acetylation can change rapidly, perhaps in minutes, although the other   
   long view also makes sense as people get epigenetics from from their parents   
   or even grandparents. I    
   perceive I read there is longevity epigenetics people get from their parents   
   so a couple days of epigenetic dosing could cause greater longevity effects   
   the person's entire life. A couple days of epigenetic modifier dosing could   
   even cause their children    
   and grandchildren to have greater longevity. At the nootropic HDAC2 inhibitor   
   that causes greater cognitive ability, a couple days of HDAC2 inhibitor dosing   
   could cause intelligence enhancement that is also passed along to children and   
   grandchildren.   
      
      
      
      
      
   Cognitive ability genetics: the genes that the published cognitive ability   
   heightening HDAC2 inhibitor modifies could be g (like iq) intelligence genes.   
   SNPs, alleles, and copy numbers of those genes could be enhanced at the   
   germline or with gene therapy    
   to increase intelligence at humans, that is homo sapiens.   
      
      
      
   Longevity technology:   
      
   I perceive piperine causes greater absorption through the membranes of the GI   
   tract from telling them to be more permeable. Is there anything that could be   
   placed at liposomes along with the active pharmaceutical ingredient (ÅPI)   
   which reach the    
   lymphatic system to make the lymphatic membranes more permeable? It could be   
   piperine again. That lymphatic permeability drug could make other drugs, like   
   rapamycin, rapalogs, or other longevity drugs to be 2-4 times as effective at   
   reaching tissues from    
   the lymphatic system. Combined with the 2-10 times greater effectiveness of   
   drugs that skip first pass hepatic metabolism that could make rapamycin,   
   rapalogs, senolytics, or other longevity drugs 4 to 20 times more active and   
   affordable. Rapamycin that    
   makes mice live 60% longer could be just 12-14 cents a dose based on $40/gram   
   at Alibaba.com .   
      
      
      
      
      
   GSK (Glaxo Smith Klein) has an online page where they request technology   
   ideas. They make Tylenol and some other antipyretic pills:   
      
      
      
   ela–naproxen (ela-n) is ethynyl liposomal active transport naproxen it is   
   active at about 7.6 micrograms. They could put a dot of it on the outside of   
   regular naproxen pill that is enteric coated so there is an immediate action   
   antipyretic at the    
   stomach but it also activates 11 hours later so one pill lasts 24 hours.   
   Another way to do it is like multiminipill contac™ with ela-n microenteric   
   coat so it dissolves better at the small intestine after 11 hours. Another way   
   to do it is rather than a    
   7 day palmitate have ela-n attached to a different alkane COOH like perhaps   
   C6COOH    
      
      
      
   To make another, delayed dose to make 24 hours of naproxen activity, that   
   could do 36, 48, 72 hour one pill dosing as well: Another way is ela-n of   
   three or more types taken simultaneously where each ela-n has a different   
   enzyme-reactive group on the ela-   
   n with a passivating group removed by the enzyme. The enzymes that remove the   
   passivation moiety are enzymes at the circulatory system. The first ela-n gets   
   its passivation moiety removed first and the next ela-n gets its passivation   
   moiety removed next    
   like cumulatively 90 minutes later, then do this with a sufficient   
   elan-enzyme-unpassivated-moieties to get a smooth 24 hour, 36 hour, 48 hour or   
   72 hour dose curve.   
      
      
      
   Years of arthritis relief from one office visit: A depot drug form of ela-n,   
   ea-n, which I calculate as having a 7.6 microgram 12 hour dose could put ela-n   
   at an implant (3 year nexplanon-like) with just 16.64 mg of API at the   
   implant. Sensibly and    
   obviously omitting the 2-4 times dosage multiplier enhancement from liposomes,   
   ae-n could be a 33 mg or 66 mg entire API content implant. I think it is   
   possible to make much longer lasting depot implants or even injections, so a   
   decade of arthritis    
   relief from a decade functional implant at one offive visit is possible.   
      
      
      
   Complementing a decade functional arthritis relief implant is putting the   
   longevity and life preserving peptides AEDG combined with thymosin at it   
      
   A peptide humanin, as well as MOT-c mitochondrial derived peptides (MDP) that   
   is beneficial to screen as to being a longevity peptide that anti aging things   
   and aging things simultaneously, the crummy part is it makes old cytes make   
   old cyte chemicals,    
   like some interleukins, the longevity thing it does is be opposite ilgf,   
   growth hormone and Alzheimer's amyloid, they have, as far as I know, fed it to   
   organisms to find out if the mice live longer and if they do, how much;   
   notably though if MDP actually    
   causes the things senolytics do then the opposite of a MDP, a receptor   
   passivator, or an immunization against MDP could be a longevity drug, the MDP   
   and antiMDP could be administered to different mice to find out if either is a   
   longevity peptide   
      
      
      
   I saw a graph suggesting longevity chemical spermidine is an acetylase   
   (histones) adjustor, it is possible that the    
      
   --- SoupGate-Win32 v1.05   
    * Origin: you cannot sedate... all the things you hate (1:229/2)