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   sci.chem      Chemistry and related sciences      55,615 messages   

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   Message 55,338 of 55,615   
   Treon Verdery to All   
   The researchers noticed mice have these    
   03 Oct 22 20:58:47   
   
   From: treon3verdery@gmail.com   
      
   Longevity technology:  Just as a person would value and utilize taking more   
   than one longevity drug to make sure different kinds of tissues were   
   simultaneous benefitting from a longevity drug, say lipophilic and hydrophilic   
   rapamycin variants (rapalogs),    
   This multi-agent technology at gene therapy and purposed epigenetic   
   modification is also beneficial, doing gene therapy on different genes that   
   effect one system has benefit, like longevizing different genetic compositions   
   of daf1,daf2,daf3, and others    
   as well as sirt1, sirt2, sirt3, and others rather than just one;  at   
   epigenetics, addressing the epigenetics of mitochondria with simultaneous   
   agents to modify other things at mitochondrial genetics besides just the UCPmt   
   genes could be characterized as    
   to human well being, notably groups of subgroups at a population of databased   
   epigenetic health records having a subgroup above the median, a subgroup above   
   the first deviation, as well as a non subgroup quantified physyiological and   
   psychometric    
   quantification at the standard devaition of variance as the entire database of   
   all the records;   
      
      
      
   the paper says, “One of the most dramatic examples in which early events   
   have effects on longevity is found in the nematode C. elegans, in which   
   mitochondrial stress during development can cause nearly a doubling of the   
   animal's lifespan   
      
      
      
   Rescueing children:  curing, preventing and treating diarrhea saves childrens   
   lives and makes them feel better; notably Oral Rehydration Therapy (ORT) is   
   published as being among the things that saved more lives than any nonvaccine   
   technology during the    
   1990s;     
      
      
      
   a complement to ORT is pieces of paper, available at 1/10th of 1 cent per   
   dose, to be affordable globally and at the developing world, attractive to   
   distributors, with anti-diarrheal peptides like octapeptide octotrieotide,   
   mu-opiod anti-fever peptides,    
   or new screened molecular variants or the antipyretic protein lipocortin1;    
      
      
      
   As an alternative to the anytipyretic lipocortin1 the drug liposomal-active   
   transport protein-ethynyl-naproxen (ELA-naproxen) could be developed; naproxen   
   is a 12 hour antipyretic, ethynylising sex hormones at things like   
   contraceptives gives them 600    
   nanogram dosages (1/1000 of a microgram per nanogram), compared with .625   
   micrograms, so the dose efficiency increases 10 times, active transport is a   
   phenomena where cells actively use energy to pull molecules into the   
   cytoplasm, it is 1000 times as    
   active as diffusion, so that is also 700-1000 times greater dose efficiency,   
   optional is dry liposomalization, where the drug is surrounded with a tiny   
   sphere of a phosphatidyl (food) molecule molecule and dried, I have read   
   online that dried liposomes    
   are good for months, that causes about 4 times greater physiological   
   availability and passage through the membranes of the small intestine;   
   together 220 mg of naproxen at the new antipyretic is 10 times 700 times 4   
   times fewer mg per dose, of about 7.9    
   micrograms per dose;   
      
      
      
   the anti-diarrheal anti-fever one dose per 1 cm paper things also have smiling   
   faces on them They are 1 cm^2 (1 cm square, like LSD), or as another form,   
   pieces of yummy candy about 2-3 mm on a side like Nerds (tm);    
      
      
      
   Notably other peptide and microgram dose drugs are printable, the GABA   
   receptor activator phenibut causes happier mood, is anxiolytic, increases some   
   cognitive abilities (nootropic), increases social fluency, reduces symptoms   
   and itch of dermatitis like    
   atopic dermatitis, and is absent regulation because of its nonhabituating   
   character; GABA receptor active peptides are published, and a library of 3000   
   variants could be screened sequentially at 100 mice, each taking 30 different   
   peptides/24 hours for a    
   month, or in-vitro GABA receptor activation could be quantified, and possibly   
   multiple simultaneous radiolabelled versions of GABA peptides at positron   
   emission tomography could be traced to their locationization at the brain,   
   spinal cord and dermis,    
   noting which brain structures and therefore ability heightening (nootropic),   
   relaxing, anxiolytic, anti-itch and screening a library of 10,000 to 100,000   
   different GABA peptide variants to find the one in vitro that most nearly   
   matched mild,    
   nonhabituating, human appreciated phenibut could be done with microfluidic   
   technology like the microfluidic chip I read about;   
      
      
      
   To globally equal or exceed the incentive of candy companies in the developed   
   world that currently make and distribute candy, at a 1/10 of 1 cents a dose,   
   the US dollar store candy has value;  At a regular grocery you can get one   
   entertainingly wrapped    
   metallized paper Andes mint for 10 cents, I perceive the Andes mint company   
   might get 5 cents for it and the distributor to the grocery store might get 7   
   cents for it; on ebay a 4 pound container of Andes mints is 7.06 per mint;    
      
      
      
   Along with the Andes mint version is the 400 Nerds(tm) candy per box version,   
   a 3-4 ounce box of candy at the dollar store in the US can have hundreds of   
   pieces (perhaps 400) per $1.00 box, and the dollar store is incentivized   
   enough to have a large    
   candy section.     
      
      
      
   The fiscal value of 10 to 100 micrograms of octotrieotide (anti-diarrheal)   
   combined with 1 milligram of the the antipyretic protein lipocortin1 (active   
   at 50 micrograms per kilogram) at $1000-$10,000 a kilogram at 1.01 mg of drug,   
   is, if it were a $1 a    
   gram, 1/1000th of a cent a dose, and if the drug ingredient is $10,000 a KG   
   then the active drugs combined are 1/100th of 1 cent a dose.   
      
      
      
   The paper component, for an 8.5 x 11 sheet of paper with drugs inkjet printed   
   or silkscreened onto it is 7 cents per sheet, 567 happy face 1 cm ^2 doses per   
   sheet, makes the paper value per dose is about 1.2/100ths of one cent. It is   
   possible that the    
   paper, the most financially prominent part of the anti-diarrhea, anti-pyretic,   
   and with GABA active peptide drug dose form is actually 3 cents rather than 7   
   cents, which would double the 87% profit margin to the distributors;   
      
      
      
   Together the drug and paper is 1.3/100ths of one cent, so at retail to the   
   family of child or adult each 1/10 of 1 cent dose at the nearest distributor,   
   which might be a place with carbohydrate staples and sweet treats, has a   
   profit margin of 87%, far    
   above many items than perhaps most items at the US dollar store;   
      
      
      
      
   [continued in next message]   
      
   --- SoupGate-Win32 v1.05   
    * Origin: you cannot sedate... all the things you hate (1:229/2)   

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