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|    sci.chem    |    Chemistry and related sciences    |    55,615 messages    |
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|    Message 55,338 of 55,615    |
|    Treon Verdery to All    |
|    The researchers noticed mice have these     |
|    03 Oct 22 20:58:47    |
      From: treon3verdery@gmail.com              Longevity technology: Just as a person would value and utilize taking more       than one longevity drug to make sure different kinds of tissues were       simultaneous benefitting from a longevity drug, say lipophilic and hydrophilic       rapamycin variants (rapalogs),        This multi-agent technology at gene therapy and purposed epigenetic       modification is also beneficial, doing gene therapy on different genes that       effect one system has benefit, like longevizing different genetic compositions       of daf1,daf2,daf3, and others        as well as sirt1, sirt2, sirt3, and others rather than just one; at       epigenetics, addressing the epigenetics of mitochondria with simultaneous       agents to modify other things at mitochondrial genetics besides just the UCPmt       genes could be characterized as        to human well being, notably groups of subgroups at a population of databased       epigenetic health records having a subgroup above the median, a subgroup above       the first deviation, as well as a non subgroup quantified physyiological and       psychometric        quantification at the standard devaition of variance as the entire database of       all the records;                            the paper says, “One of the most dramatic examples in which early events       have effects on longevity is found in the nematode C. elegans, in which       mitochondrial stress during development can cause nearly a doubling of the       animal's lifespan                            Rescueing children: curing, preventing and treating diarrhea saves childrens       lives and makes them feel better; notably Oral Rehydration Therapy (ORT) is       published as being among the things that saved more lives than any nonvaccine       technology during the        1990s;                             a complement to ORT is pieces of paper, available at 1/10th of 1 cent per       dose, to be affordable globally and at the developing world, attractive to       distributors, with anti-diarrheal peptides like octapeptide octotrieotide,       mu-opiod anti-fever peptides,        or new screened molecular variants or the antipyretic protein lipocortin1;                             As an alternative to the anytipyretic lipocortin1 the drug liposomal-active       transport protein-ethynyl-naproxen (ELA-naproxen) could be developed; naproxen       is a 12 hour antipyretic, ethynylising sex hormones at things like       contraceptives gives them 600        nanogram dosages (1/1000 of a microgram per nanogram), compared with .625       micrograms, so the dose efficiency increases 10 times, active transport is a       phenomena where cells actively use energy to pull molecules into the       cytoplasm, it is 1000 times as        active as diffusion, so that is also 700-1000 times greater dose efficiency,       optional is dry liposomalization, where the drug is surrounded with a tiny       sphere of a phosphatidyl (food) molecule molecule and dried, I have read       online that dried liposomes        are good for months, that causes about 4 times greater physiological       availability and passage through the membranes of the small intestine;       together 220 mg of naproxen at the new antipyretic is 10 times 700 times 4       times fewer mg per dose, of about 7.9        micrograms per dose;                            the anti-diarrheal anti-fever one dose per 1 cm paper things also have smiling       faces on them They are 1 cm^2 (1 cm square, like LSD), or as another form,       pieces of yummy candy about 2-3 mm on a side like Nerds (tm);                             Notably other peptide and microgram dose drugs are printable, the GABA       receptor activator phenibut causes happier mood, is anxiolytic, increases some       cognitive abilities (nootropic), increases social fluency, reduces symptoms       and itch of dermatitis like        atopic dermatitis, and is absent regulation because of its nonhabituating       character; GABA receptor active peptides are published, and a library of 3000       variants could be screened sequentially at 100 mice, each taking 30 different       peptides/24 hours for a        month, or in-vitro GABA receptor activation could be quantified, and possibly       multiple simultaneous radiolabelled versions of GABA peptides at positron       emission tomography could be traced to their locationization at the brain,       spinal cord and dermis,        noting which brain structures and therefore ability heightening (nootropic),       relaxing, anxiolytic, anti-itch and screening a library of 10,000 to 100,000       different GABA peptide variants to find the one in vitro that most nearly       matched mild,        nonhabituating, human appreciated phenibut could be done with microfluidic       technology like the microfluidic chip I read about;                            To globally equal or exceed the incentive of candy companies in the developed       world that currently make and distribute candy, at a 1/10 of 1 cents a dose,       the US dollar store candy has value; At a regular grocery you can get one       entertainingly wrapped        metallized paper Andes mint for 10 cents, I perceive the Andes mint company       might get 5 cents for it and the distributor to the grocery store might get 7       cents for it; on ebay a 4 pound container of Andes mints is 7.06 per mint;                             Along with the Andes mint version is the 400 Nerds(tm) candy per box version,       a 3-4 ounce box of candy at the dollar store in the US can have hundreds of       pieces (perhaps 400) per $1.00 box, and the dollar store is incentivized       enough to have a large        candy section.                             The fiscal value of 10 to 100 micrograms of octotrieotide (anti-diarrheal)       combined with 1 milligram of the the antipyretic protein lipocortin1 (active       at 50 micrograms per kilogram) at $1000-$10,000 a kilogram at 1.01 mg of drug,       is, if it were a $1 a        gram, 1/1000th of a cent a dose, and if the drug ingredient is $10,000 a KG       then the active drugs combined are 1/100th of 1 cent a dose.                            The paper component, for an 8.5 x 11 sheet of paper with drugs inkjet printed       or silkscreened onto it is 7 cents per sheet, 567 happy face 1 cm ^2 doses per       sheet, makes the paper value per dose is about 1.2/100ths of one cent. It is       possible that the        paper, the most financially prominent part of the anti-diarrhea, anti-pyretic,       and with GABA active peptide drug dose form is actually 3 cents rather than 7       cents, which would double the 87% profit margin to the distributors;                            Together the drug and paper is 1.3/100ths of one cent, so at retail to the       family of child or adult each 1/10 of 1 cent dose at the nearest distributor,       which might be a place with carbohydrate staples and sweet treats, has a       profit margin of 87%, far        above many items than perhaps most items at the US dollar store;                                   [continued in next message]              --- SoupGate-Win32 v1.05        * Origin: you cannot sedate... all the things you hate (1:229/2)    |
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