From: treon3verdery@gmail.com   
      
   Chemical molecular entertainment:  Is it possible to make a pleasant   
   nootropic, or a highly effective nootropic into a longevity drug; phenibut   
   could have a c=c on it, and a distal =O and a -O, but it might not pass the   
   blood brain barrier, it would    
   still have the distal phenyl on it though (entertainment, not an actual   
   product), phenylethylamine, which causes me to write up to 44 pages of notes   
   on new ideas during about 24-48 hours could have some more alkane C-C   
   happening after the N, and at the    
   further distal alkane could have the =O and -O at a decanoic (10 C) acid, it   
   might do anything, it might be a stimulating nootropic that at 10HDA 60-600mg   
   doses caused mammals like mice to live double digit percentages 25(27%)longer,   
   or even the 46%    
   greater longevity at c elegans   
      
      
      
      
      
   Notably, at previous notes grinding up termite queens (half century longevity)   
   and feeding them to mice, with an enteric coating on the ground up termite   
   material, as well as findout if c elegans lived longer with termite hemolymph   
   at their food or    
   medium was described as a possible longevity drug finding area, termite queens   
   make 90DA, a royal jelly function like chemical   
      
      
      
      
      
      
      
   10HDA numbers: “A main component of royal jelly is 10HDA, which can compose   
   2–6% of royal jelly; this translates into a 100–300mM concentration in   
   royal jelly.”, that also suggests, as the ratio of a published sample of   
   royal jelly was about 3    
   parts 10 H2DA to 1 part 10 HDA that royal jelly could actually be 18% 10 H2DA,   
   or 24% all 10DHAlike lipids, although that 1/4 lipids thing seems different   
   than the way lyohilized royal jelly looks;   
      
   the paper where 10DHA is a thing that turns a methylated gene back on is able   
   to do that with a similar, but different system, at 5mM, and that royal jelly   
   is 100-300 mM, that suggests the plausability that getting 10HDA to the   
   largest variety of tissues    
   could provide a longevity benefit that complements and enhances getting an   
   equivalent to mouse longevity dose amount of 10HDA (or also royalactin), that   
   suggests three sizes of liposomes, and three different phosphatidyl   
   compositions of liposomes, as    
   well as variety at physioavailability enhancers like piperine and quercetin   
   simultneously   
      
      
      
      
      
   surveying libraries is beneficial, they might even find new disease treatments   
   as well,    
      
      
      
   Noting the screen all FDA drugs to find longevity drugs screening a library   
   approach, numerous dna on the histone activity drugs like HDACs as well as   
   HDIs as well as (possibly) HATS are anti-cancer drugs, screening all FDA   
   anti-cancer drugs as well as    
   HDIs to find new longevity drugs, noting that I just noticed FDA anti-cancer   
   drugs also contain chromatin-access drugs, this could find new longevity   
   drugs.  Online it says that HDIs increase longevity at organisms, suggesting   
   mouse screening of all FDA    
   HDI, HDAC, HAT other chromatin accessibility acvtive drugs is a longevity drug   
   finding activity   
      
      
      
   It is likely a more effective HDI that is a peptide is possible, a paper says,   
   “cyclic peptides are the most structurally complex group of HDAC inhibitors   
   and include depsipeptide, apicidin, and the cyclic hydroxamic acid-containing   
   peptide group of    
   molecules”    
      
      
      
   10HDA as an autophagy longevity drug:  10 HDA might cause more autophagy, a   
   thing they could see if it happens, (at the study where 10HDA makes the daf 2   
   mutants live 46% longer) “10-HDA did not extend the lifespan of the eat-2   
   mutants, which show long    
   lifespan through dietary restriction caused by a food-intake defect. This   
   finding indicates that 10-HDA extends lifespan through dietary restriction   
   signaling.” I perceive calorie restriction longevity effects heighten   
   autophagy and protein recycling,    
   so localization of 10HDA forms might cause some kind of tissue youthification   
   if 10HDA causes greater autophagy, so cardioarea as well as vascular   
   heightened autophagy might go with reducing heart disease, I read autophagy at   
   neurons is beneficial, “   
   Upregulation of this pathway may be neuroprotective, and much effort is being   
   invested in developing drugs that cross the blood brain barrier and increase   
   neuronal autophagy.” so a 10HDA variation that passes the blood brain   
   barrier even more than    
   10DHA could be a beneficial drug, perhaps the threonate amino acid at Mg   
   threonate could do it, or, at a few amu molecule acetylation (passes blood   
   brain barrier) of 10HDA versions could be measured as to beneficial effects on   
   mouse longevity and    
   congitive youthfulness; an acetyl group on the 120HDA that causes it to pass   
   the blood brain barrier a bunch more could be chemically obvious if you asked   
   a chemist,  to make, and maintain the few-AMU size of the molecule, a halogen   
   (p-cholophenoxy    
   moiety) might do it as well,    
      
      
      
   A liposomal pharmaceutical is about 4 times as physiologically available   
   because it omits first pass heaptic metabolism from going directly to the   
   lymphatic compartment, it could be that liposomal 10HDA has 4 times greater   
   effect at a mg/dose; 10HDA is    
   on alibaba, as is royal jelly, so comparatively big amounts of liposomal royal   
   jelly, or a few tens or hundreds of mg of liposomal just 10HDA could be more   
   effective longevity drugs (mice 25(27%), c elegans 18-46%); also it is   
   possible that liposomes    
   reach different tissues compared with oral royal jelly, royal jelly at enteric   
   capsules, as well as pure 10HDA which is alibabaish, Also, even though a   
   person making juice only gets some juice and some wet unpressed mass, a   
   solvent extraction of royal    
   jelly, which I could ask a chemist on fiverr about, would leave a pressed mass   
   that I could still eat for 10HDA as well as royal jelly benefits if the   
   solvent is edible;  thinking about the places liposomal 10 HDA or even   
   liposomal royal jelly could    
   travel to, one online thing mentioned that liposomes might not always be   
   beneficial to the tissues they visit, that brings up the possibility of making   
   liposomes from completely brain beneficial phospholipids, I perceive   
   phosphatidylserine “   
   Phosphatidylserine (PS) is a phospholipid component of the membrane encasing   
   every one of your brain cells”, is a beneficial nootropic, so even though   
   the 10DHA liposomes could travel the entire body, if a quantity of them made   
   it past the blood brain    
   barrier they would be made of a brain-beneficial phospholipid ph   
   sphatidylserine chemical; DHA phosphatidylserine EPA together cause greater   
   cheerfulness   
      
      
      
      
   [continued in next message]   
      
   --- SoupGate-Win32 v1.05   
    * Origin: you cannot sedate... all the things you hate (1:229/2)