From: sufent007@gmail.com   
      
   On Monday, December 2, 2002 at 11:43:53 AM UTC-5, Dustin Caras wrote:   
   > Hello,   
   > I have synthesized 1034 grams of 2-Carbomethoxytropinone (It has   
   > costed me a $1950, I can give you a list of suppliers I've used), and   
   > I am stuck with converting it to methylecgonine.   
   > Could anyone advise which method to use, references to some papers   
   > would be helpfull.   
   > What is the ratio? like 100grams would convert into X grams of   
   > methylecgonine?   
   >    
   > Thanks,   
   > Dustin   
   Great work, Besides the classic findlay paper there is a paper in JOC in 1974   
   from university of Davis professor Bottini who makes Tropinone in 2 steps from   
   the readily available cycoheptanone and bromine followed by double Michael   
   addition of methyl    
   amine to give tropinone in excellent yield. This can be acylated to   
   2-carbomethoxy tropinone by sodium or potassium ethoxide and dimethyl   
   carbonate as mentioned in 1953 Findlays article. Optical resoltion followed by   
   sodium amalgam reduction results in    
   the desired enantiomer of cocaine which on benzoylation gives pure cocaine   
      
   --- SoupGate-Win32 v1.05   
    * Origin: you cannot sedate... all the things you hate (1:229/2)