From: me22over7@gmail.com   
      
   On 15/01/2026 12:41 pm, MarkE wrote:   
      
      
      
   > Would this be an accurate assessment of where our discussion is at?   
   >   
   > With your position, you are in effect affirming the so-called central   
   > dogma of biology, i.e. information flows sequentially from DNA → RNA →   
   > protein, and not in reverse.   
   >   
   > I'm suggesting instead something along the lines of Dennis Noble. If I   
   > understand correctly, he accepts this biochemical pipeline, but rejects   
   > that DNA is the primary or privileged source of biological causation.   
   > Rather, he argues that biological systems are causally bidirectional and   
   > distributed across multiple levels of organisation.   
   >   
   > If Noble was shown to be right, would my logic then be valid?   
      
   PS   
      
   AI summarises nicely why this matters:   
      
      
   * Why This Is Devastating to Gene-Centric Darwinism   
      
   Traditional Darwinism assumes:   
      
   Mutations in DNA → changes in proteins → changes in traits → selection   
      
   Noble shows that causation also runs:   
      
   physiology → cellular state → chromatin structure → gene expression →   
   mutation bias   
      
   So the genome is not an independent driver; it is embedded in a   
   self-regulating system.   
      
   This means:   
      
   Evolution does not act only on genes   
      
   Development does not read a script   
      
   Information is not stored only in DNA   
      
   The fertilized egg already contains a rich informational architecture   
   that Darwinism never explains.   
      
      
      
      
   --- SoupGate-Win32 v1.05   
    * Origin: you cannot sedate... all the things you hate (1:229/2)