From: rokimoto557@gmail.com   
      
   On 1/14/2026 7:49 PM, MarkE wrote:   
   > On 15/01/2026 12:41 pm, MarkE wrote:   
   >   
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   >   
   >> Would this be an accurate assessment of where our discussion is at?   
   >>   
   >> With your position, you are in effect affirming the so-called central   
   >> dogma of biology, i.e. information flows sequentially from DNA → RNA →   
   >> protein, and not in reverse.   
   >>   
   >> I'm suggesting instead something along the lines of Dennis Noble. If I   
   >> understand correctly, he accepts this biochemical pipeline, but   
   >> rejects that DNA is the primary or privileged source of biological   
   >> causation. Rather, he argues that biological systems are causally   
   >> bidirectional and distributed across multiple levels of organisation.   
   >>   
   >> If Noble was shown to be right, would my logic then be valid?   
   >   
   > PS   
   >   
   > AI summarises nicely why this matters:   
   >   
   >   
   > * Why This Is Devastating to Gene-Centric Darwinism   
   >   
   > Traditional Darwinism assumes:   
   >   
   > Mutations in DNA → changes in proteins → changes in traits → selection   
   >   
   > Noble shows that causation also runs:   
   >   
   > physiology → cellular state → chromatin structure → gene expression →   
   > mutation bias   
   >   
   > So the genome is not an independent driver; it is embedded in a self-   
   > regulating system.   
   >   
   > This means:   
   >   
   > Evolution does not act only on genes   
   >   
   > Development does not read a script   
   >   
   > Information is not stored only in DNA   
   >   
   > The fertilized egg already contains a rich informational architecture   
   > that Darwinism never explains.   
      
   This is just wrong about Darwinism if what is being claimed is just   
   evolution by natural selection.  Natural selection selects on the whole   
   organism.  Any genetic change has to work within the system that is   
   already working in order to produce an organism that has a viable chance   
   of being selected for.  This means that the genome has never been an   
   independent driver of natural selection.  Every genetic change has to   
   work with the existing cellular information in order to correctly   
   replicate and for the successful development of an individual from a   
   single fertilized egg cell.  This just means that the genome has never   
   been expected to be an independent driver of biological evolution.  It   
   has always been known that the genome has to function in a functional   
   cell.  If that is all Noble is claiming then he isn't claiming much of   
   anything that is going to help you at all.  All it means is that the ID   
   perps and you are not dealing with the information that you need to be   
   dealing with, and you will not be dealing with that information in any   
   meaningful way because you can't quantify it and you can't even identify   
   what a lot of it is.   
      
   Ron Okimoto   
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   --- SoupGate-Win32 v1.05   
    * Origin: you cannot sedate... all the things you hate (1:229/2)