From: me22over7@gmail.com   
      
   On 3/02/2026 12:11 pm, John Harshman wrote:   
   > On 2/1/26 6:02 PM, MarkE wrote:   
   >> On 2/02/2026 3:44 am, John Harshman wrote:   
   >>> On 1/31/26 10:18 PM, MarkE wrote:   
   >>>> On 1/02/2026 9:11 am, John Harshman wrote:   
   >>>>> On 1/31/26 1:58 AM, MarkE wrote:   
   >>>>>> On 31/01/2026 2:37 pm, John Harshman wrote:   
   >>>>>>> On 1/30/26 5:26 PM, MarkE wrote:   
   >>>>>>>> On 31/01/2026 5:56 am, John Harshman wrote:   
   >>>>>>>>> On 1/29/26 9:54 PM, MarkE wrote:   
   >>>>>>>>>> On 30/01/2026 3:17 pm, John Harshman wrote:   
   >>>>>>>>>>> On 1/29/26 7:57 PM, MarkE wrote:   
   >>>>>>>>>>>> On 30/01/2026 2:10 pm, John Harshman wrote:   
   >>>>>>>>>>>>> On 1/29/26 6:40 PM, MarkE wrote:   
   >>>>>>>>>>>>>> On 30/01/2026 12:50 pm, John Harshman wrote:   
   >>>>>>>>>>>>>>> On 1/29/26 5:31 PM, MarkE wrote:   
   >>>>>>>>>>>>>>>> On 30/01/2026 11:20 am, John Harshman wrote:   
   >>>>>>>>>>>>>>>>> On 1/29/26 3:37 AM, MarkE wrote:   
   >>>>>>>>>>>>>>>>>> On 27/01/2026 11:41 am, John Harshman wrote:   
   >>>>>>>>>>>>>>>>>>> On 1/24/26 3:28 AM, MarkE wrote:   
   >>>>>>>>>>>>>>>>>>>> On 24/01/2026 1:54 am, John Harshman wrote:   
   >>>>>>>>>>>>>>>>>>>>> On 1/22/26 6:15 PM, MarkE wrote:   
   >>>>>>>>>>>>>>>>>>>>>> On 23/01/2026 1:31 am, John Harshman wrote:   
   >>>>>>>>>>>>>>>>>>>>>>> On 1/21/26 9:18 PM, MarkE wrote:   
   >>>>>>>>>>>>>>>>>>>>>>>> On 22/01/2026 3:22 am, John Harshman wrote:   
   >>>>>>>>>>>>>>>>>>   
   >>>>>>>>>>>>>>>>>> ...   
   >>>>>>>>>>>>>>>>>>   
   >>>>>>>>>>>>>>>>>>>>>>> Now if you're interested in what makes an   
   >>>>>>>>>>>>>>>>>>>>>>> organism, without much regard for what kind of   
   >>>>>>>>>>>>>>>>>>>>>>> organism, you have a point that the ovum has   
   >>>>>>>>>>>>>>>>>>>>>>> various bits that must be in place in order to   
   >>>>>>>>>>>>>>>>>>>>>>> get the process of development going, and that   
   >>>>>>>>>>>>>>>>>>>>>>> there are many interactions between cells that   
   >>>>>>>>>>>>>>>>>>>>>>> are not directly controlled by the genome. But   
   >>>>>>>>>>>>>>>>>>>>>>> the source of the bits that interact is still the   
   >>>>>>>>>>>>>>>>>>>>>>> genome, at first the maternal genome and later   
   >>>>>>>>>>>>>>>>>>>>>>> the zygote's.   
   >>>>>>>>>>>>>>>>>>>>>>>   
   >>>>>>>>>>>>>>>>>>>>   
   >>>>>>>>>>>>>>>>>>>> Certainly all proteins in the cell are produced from   
   >>>>>>>>>>>>>>>>>>>> gene coding. However, doesn't the following (for   
   >>>>>>>>>>>>>>>>>>>> example) demonstrate that the cytoplasm is in   
   >>>>>>>>>>>>>>>>>>>> control and telling the DNA what to do (so to speak):   
   >>>>>>>>>>>>>>>>>>>>   
   >>>>>>>>>>>>>>>>>>>> "It is concluded that whenever nuclei are introduced   
   >>>>>>>>>>>>>>>>>>>> experimentally into the cytoplasm of another cell,   
   >>>>>>>>>>>>>>>>>>>> they very quickly assume, in nearly every respect,   
   >>>>>>>>>>>>>>>>>>>> the nuclear activity characteristic of the host   
   >>>>>>>>>>>>>>>>>>>> cell. In many instances, altered function has been   
   >>>>>>>>>>>>>>>>>>>> demonstrated in nuclei which subsequently support   
   >>>>>>>>>>>>>>>>>>>> normal development." [1]   
   >>>>>>>>>>>>>>>>>>>   
   >>>>>>>>>>>>>>>>>>> Sure, that's because various transcription factors   
   >>>>>>>>>>>>>>>>>>> and such are in the cytoplasm, having been   
   >>>>>>>>>>>>>>>>>>> transcribed and translated from the previous nucleus.   
   >>>>>>>>>>>>>>>>>>> Differences between genomes result in differences in   
   >>>>>>>>>>>>>>>>>>> expression.   
   >>>>>>>>>>>>>>>>>>>   
   >>>>>>>>>>>>>>>>>>>> Here's the critical logic: if the direction of   
   >>>>>>>>>>>>>>>>>>>> control flow is bi- directional, then to resolve a   
   >>>>>>>>>>>>>>>>>>>> chicken- and- egg paradox, we must conclude that   
   >>>>>>>>>>>>>>>>>>>> information is initially present in both the nucleus   
   >>>>>>>>>>>>>>>>>>>> and extra- nuclear, in effectively digital and   
   >>>>>>>>>>>>>>>>>>>> analogue form respectively.   
   >>>>>>>>>>>>>>>>>>>   
   >>>>>>>>>>>>>>>>>>> "Digital" and "analog" are empty buzzwords in this   
   >>>>>>>>>>>>>>>>>>> context. But yes, proteins contain information, if   
   >>>>>>>>>>>>>>>>>>> that's what you mean. But that information is   
   >>>>>>>>>>>>>>>>>>> inherited, over the long term, in the form of DNA.   
   >>>>>>>>>>>>>>>>>>   
   >>>>>>>>>>>>>>>>>> On what basis do you deem these "empty buzzwords"?   
   >>>>>>>>>>>>>>>>>>   
   >>>>>>>>>>>>>>>>>> A digital information medium stores heritable   
   >>>>>>>>>>>>>>>>>> information in discrete symbolic sequences that are   
   >>>>>>>>>>>>>>>>>> copied and decoded by rule- based molecular machinery.   
   >>>>>>>>>>>>>>>>>> The human genome at 3.2 billion base pairs can be   
   >>>>>>>>>>>>>>>>>> simply mapped into 6.4 billion bits of digital   
   >>>>>>>>>>>>>>>>>> information. Are we agreed that DNA can be accurately   
   >>>>>>>>>>>>>>>>>> described as *digital* information? (Along with its   
   >>>>>>>>>>>>>>>>>> chemical and structural/ physical properties and   
   >>>>>>>>>>>>>>>>>> interactions.)   
   >>>>>>>>>>>>>>>>>   
   >>>>>>>>>>>>>>>>> That's an analogy. It's not a hopeless one, but it's   
   >>>>>>>>>>>>>>>>> still an analogy.   
   >>>>>>>>>>>>>>>>   
   >>>>>>>>>>>>>>>> No, it's not an analogy, it's a legitimate application   
   >>>>>>>>>>>>>>>> of a definition and identification of actual digital   
   >>>>>>>>>>>>>>>> information, and large amount of it at that.   
   >>>>>>>>>>>>>>>>   
   >>>>>>>>>>>>>>>> What do you imagine would not be an analogy? Cut open an   
   >>>>>>>>>>>>>>>> alien lifeform and see 0s and 1s pour out?   
   >>>>>>>>>>>>>>   
      
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