From: me22over7@gmail.com   
      
   On 4/02/2026 10:32 pm, MarkE wrote:   
   > On 3/02/2026 2:14 pm, John Harshman wrote:   
   >> On 2/2/26 6:05 PM, MarkE wrote:   
   >>> On 3/02/2026 12:11 pm, John Harshman wrote:   
   >>>> On 2/1/26 6:02 PM, MarkE wrote:   
   >>>>> On 2/02/2026 3:44 am, John Harshman wrote:   
   >>>>>> On 1/31/26 10:18 PM, MarkE wrote:   
   >>>>>>> On 1/02/2026 9:11 am, John Harshman wrote:   
   >>>>>>>> On 1/31/26 1:58 AM, MarkE wrote:   
   >>>>>>>>> On 31/01/2026 2:37 pm, John Harshman wrote:   
   >>>>>>>>>> On 1/30/26 5:26 PM, MarkE wrote:   
   >>>>>>>>>>> On 31/01/2026 5:56 am, John Harshman wrote:   
   >>>>>>>>>>>> On 1/29/26 9:54 PM, MarkE wrote:   
   >>>>>>>>>>>>> On 30/01/2026 3:17 pm, John Harshman wrote:   
   >>>>>>>>>>>>>> On 1/29/26 7:57 PM, MarkE wrote:   
   >>>>>>>>>>>>>>> On 30/01/2026 2:10 pm, John Harshman wrote:   
   >>>>>>>>>>>>>>>> On 1/29/26 6:40 PM, MarkE wrote:   
   >>>>>>>>>>>>>>>>> On 30/01/2026 12:50 pm, John Harshman wrote:   
   >>>>>>>>>>>>>>>>>> On 1/29/26 5:31 PM, MarkE wrote:   
   >>>>>>>>>>>>>>>>>>> On 30/01/2026 11:20 am, John Harshman wrote:   
   >>>>>>>>>>>>>>>>>>>> On 1/29/26 3:37 AM, MarkE wrote:   
   >>>>>>>>>>>>>>>>>>>>> On 27/01/2026 11:41 am, John Harshman wrote:   
   >>>>>>>>>>>>>>>>>>>>>> On 1/24/26 3:28 AM, MarkE wrote:   
   >>>>>>>>>>>>>>>>>>>>>>> On 24/01/2026 1:54 am, John Harshman wrote:   
   >>>>>>>>>>>>>>>>>>>>>>>> On 1/22/26 6:15 PM, MarkE wrote:   
   >>>>>>>>>>>>>>>>>>>>>>>>> On 23/01/2026 1:31 am, John Harshman wrote:   
   >>>>>>>>>>>>>>>>>>>>>>>>>> On 1/21/26 9:18 PM, MarkE wrote:   
   >>>>>>>>>>>>>>>>>>>>>>>>>>> On 22/01/2026 3:22 am, John Harshman wrote:   
   >>>>>>>>>>>>>>>>>>>>>   
   >>>>>>>>>>>>>>>>>>>>> ...   
   >>>>>>>>>>>>>>>>>>>>>   
   >>>>>>>>>>>>>>>>>>>>>>>>>> Now if you're interested in what makes an   
   >>>>>>>>>>>>>>>>>>>>>>>>>> organism, without much regard for what kind of   
   >>>>>>>>>>>>>>>>>>>>>>>>>> organism, you have a point that the ovum has   
   >>>>>>>>>>>>>>>>>>>>>>>>>> various bits that must be in place in order to   
   >>>>>>>>>>>>>>>>>>>>>>>>>> get the process of development going, and that   
   >>>>>>>>>>>>>>>>>>>>>>>>>> there are many interactions between cells that   
   >>>>>>>>>>>>>>>>>>>>>>>>>> are not directly controlled by the genome. But   
   >>>>>>>>>>>>>>>>>>>>>>>>>> the source of the bits that interact is still   
   >>>>>>>>>>>>>>>>>>>>>>>>>> the genome, at first the maternal genome and   
   >>>>>>>>>>>>>>>>>>>>>>>>>> later the zygote's.   
   >>>>>>>>>>>>>>>>>>>>>>>>>>   
   >>>>>>>>>>>>>>>>>>>>>>>   
   >>>>>>>>>>>>>>>>>>>>>>> Certainly all proteins in the cell are produced   
   >>>>>>>>>>>>>>>>>>>>>>> from gene coding. However, doesn't the following   
   >>>>>>>>>>>>>>>>>>>>>>> (for example) demonstrate that the cytoplasm is   
   >>>>>>>>>>>>>>>>>>>>>>> in control and telling the DNA what to do (so to   
   >>>>>>>>>>>>>>>>>>>>>>> speak):   
   >>>>>>>>>>>>>>>>>>>>>>>   
   >>>>>>>>>>>>>>>>>>>>>>> "It is concluded that whenever nuclei are   
   >>>>>>>>>>>>>>>>>>>>>>> introduced experimentally into the cytoplasm of   
   >>>>>>>>>>>>>>>>>>>>>>> another cell, they very quickly assume, in nearly   
   >>>>>>>>>>>>>>>>>>>>>>> every respect, the nuclear activity   
   >>>>>>>>>>>>>>>>>>>>>>> characteristic of the host cell. In many   
   >>>>>>>>>>>>>>>>>>>>>>> instances, altered function has been demonstrated   
   >>>>>>>>>>>>>>>>>>>>>>> in nuclei which subsequently support normal   
   >>>>>>>>>>>>>>>>>>>>>>> development." [1]   
   >>>>>>>>>>>>>>>>>>>>>>   
   >>>>>>>>>>>>>>>>>>>>>> Sure, that's because various transcription factors   
   >>>>>>>>>>>>>>>>>>>>>> and such are in the cytoplasm, having been   
   >>>>>>>>>>>>>>>>>>>>>> transcribed and translated from the previous   
   >>>>>>>>>>>>>>>>>>>>>> nucleus. Differences between genomes result in   
   >>>>>>>>>>>>>>>>>>>>>> differences in expression.   
   >>>>>>>>>>>>>>>>>>>>>>   
   >>>>>>>>>>>>>>>>>>>>>>> Here's the critical logic: if the direction of   
   >>>>>>>>>>>>>>>>>>>>>>> control flow is bi- directional, then to resolve   
   >>>>>>>>>>>>>>>>>>>>>>> a chicken- and- egg paradox, we must conclude   
   >>>>>>>>>>>>>>>>>>>>>>> that information is initially present in both the   
   >>>>>>>>>>>>>>>>>>>>>>> nucleus and extra- nuclear, in effectively   
   >>>>>>>>>>>>>>>>>>>>>>> digital and analogue form respectively.   
   >>>>>>>>>>>>>>>>>>>>>>   
   >>>>>>>>>>>>>>>>>>>>>> "Digital" and "analog" are empty buzzwords in this   
   >>>>>>>>>>>>>>>>>>>>>> context. But yes, proteins contain information, if   
   >>>>>>>>>>>>>>>>>>>>>> that's what you mean. But that information is   
   >>>>>>>>>>>>>>>>>>>>>> inherited, over the long term, in the form of DNA.   
   >>>>>>>>>>>>>>>>>>>>>   
   >>>>>>>>>>>>>>>>>>>>> On what basis do you deem these "empty buzzwords"?   
   >>>>>>>>>>>>>>>>>>>>>   
   >>>>>>>>>>>>>>>>>>>>> A digital information medium stores heritable   
   >>>>>>>>>>>>>>>>>>>>> information in discrete symbolic sequences that are   
   >>>>>>>>>>>>>>>>>>>>> copied and decoded by rule- based molecular   
   >>>>>>>>>>>>>>>>>>>>> machinery. The human genome at 3.2 billion base   
   >>>>>>>>>>>>>>>>>>>>> pairs can be simply mapped into 6.4 billion bits of   
   >>>>>>>>>>>>>>>>>>>>> digital information. Are we agreed that DNA can be   
   >>>>>>>>>>>>>>>>>>>>> accurately described as *digital* information?   
   >>>>>>>>>>>>>>>>>>>>> (Along with its chemical and structural/ physical   
   >>>>>>>>>>>>>>>>>>>>> properties and interactions.)   
   >>>>>>>>>>>>>>>>>>>>   
   >>>>>>>>>>>>>>>>>>>> That's an analogy. It's not a hopeless one, but it's   
      
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