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   FRIDAY, June 10, 2022 (HealthDay News) -- The babies of women   
   infected with COVID-19 during pregnancy may have developmental   
   difficulties during their first year, a new study suggests.   
      
   Researchers found that pregnant women with COVID-19 were more   
   likely to have preterm births and infants with developmental   
   problems. The greatest risk was in the third trimester, the   
   study found.   
      
   "The kinds of diagnoses we see are delays in motor and speech   
   milestones, but it's important to recognize that these are very   
   nonspecific and may well resolve over time," said lead   
   researcher Dr. Roy Perlis, director of the Center for   
   Quantitative Health at Massachusetts General Hospital in Boston.   
      
   Perlis stressed that the abnormalities were rare and most   
   infants were developmentally normal.   
      
   "The vast majority of offspring of mothers infected with COVID-   
   19, even if they were delivered preterm, did not have these   
   neurodevelopmental diagnoses. They also did not have any other   
   abnormalities," Perlis said. "It is entirely possible that these   
   differences between exposed and unexposed children will become   
   smaller over time, as the developing brain is incredibly   
   resilient."   
      
   Perlis said it will be important to follow the children with   
   developmental difficulties, because other differences may emerge   
   as they get older.   
      
   Although it's unclear how COVID-19 might cause these   
   developmental problems, other studies have suggested that   
   anything that causes inflammation during pregnancy can be tied   
   to changes in brain development. "But we do not know the precise   
   mechanism, if any," Perlis said.   
      
   And, he added, as variants of SARS-CoV-2 appear, they may affect   
   babies in different ways.   
      
   "Our study focused on pregnancies that occurred earlier in the   
   pandemic, so we do not know if there might be strain-specific   
   effects, but we will certainly look at this in future studies,"   
   Perlis noted.   
      
   These potential dangers are another good reason for pregnant   
   women and those who plan to get pregnant to get the COVID-19   
   vaccine.   
      
   "There are so many good reasons to be vaccinated, regardless of   
   pregnancy status," he said. "Our study doesn't speak to   
   vaccination effects, but if it encourages more women to seek   
   vaccination, that would be a great outcome."   
      
   For the study, Perlis and his team collected data on nearly   
   7,800 births at six Massachusetts hospitals between March and   
   September of 2020. In all, 222 of the mothers had tested   
   positive for COVID-19.   
      
   Among those women, 14% had a preterm delivery, compared with   
   about 9% of the women who weren't infected.   
      
   And, the investigators found, 6% of children born to infected   
   moms had a developmental problem during their first year of   
   life, compared with 3% of those whose moms weren't infected. The   
   most common problems involved motor function, and speech and   
   language difficulties.   
      
   Dr. Marc Siegel, a clinical professor of medicine at NYU Langone   
   Medical Center in New York City, said that the study showed that   
   even if a fetus doesn't get COVID from the mother, inflammation   
   from the disease may cause problems after delivery.   
      
   "This is of concern and requires further study, and also   
   emphasizes that getting the vaccine during pregnancy is not only   
   safe but also decreases your risk of having problems with the   
   baby from COVID itself," Siegel said.   
      
   He added that the effects of virus strains like Omicron remain   
   unclear. In addition, it is not known if breakthrough infections   
   after vaccination might result in similar developmental problems.   
      
   "We also don't know, and this is the most important thing, if   
   neurodevelopmental delays or other neurological issues   
   correlated with the severity of illness," he said.   
      
   Importantly, Siegel said, vaccination decreases disease severity.   
      
   "My suspicion is that the vaccine decreases your risk of the   
   kind of COVID case that would impact your fetus," Siegel said.   
   "So, even if this is just preliminary data, it's a further   
      
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